Author(s): Dasari Nirmala, Enjamuri Aslesha, M. Sudhakar

Email(s): dasarinirmala1980@gmail.com

DOI: Not Available

Address: Dasari Nirmala, Enjamuri Aslesha , M. Sudhakar
Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad -500100 Telangana State India affiliated to Osmania University.
*Corresponding Author

Published In:   Volume - 6,      Issue - 4,     Year - 2016


ABSTRACT:
The present study was carried out with an objective of formulation and evaluation of floating tablets of baclofen for prolongation of gastric residence time with a view to deliver the drug at controlled manner in gastrointestinal tract and consequently into systemic circulation. Baclofen, a centrally acting skeletal muscle relaxant, is indicated in the long-term treatment of spasticity resulting for multiple sclerosis and spinal cord injuries. Therefore baclofen floating tablets were prepared by direct compression method using 3 grades of Eudragit (Eudragit L100, Eudragit S100, and Eudragit RSPO). Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymers/excipient interactions. The prepared floating tablets were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, total floating time, water uptake (swelling index) and in-vitro dissolution studies. Among the 12 formulations F3 showed drug release 98.37% in pH 1.2 dissolution medium. All the formulations showed drug content ranging from 80.93 to 98.37%. Drug release rate kinetics studies shown that drug release follows Higuchi mechanism.


Cite this article:
Dasari Nirmala, Enjamuri Aslesha , M. Sudhakar. Formulation and Evaluation of Baclofen Floating Tablets. Asian J. Res. Pharm. Sci. 2016; 6(4): 255-260.


Recomonded Articles:

Author(s): Yogita R. Indalkar, Nayana V. Pimpodkar, Puja S. Gaikwad, Anita S. Godase

DOI: 10.5958/2231-5659.2016.00010.2         Access: Open Access Read More

Author(s): Muhammed Jameel VP, Ravikumar, Narayanaswamy VB

DOI: 10.5958/2231-5659.2016.00017.5         Access: Open Access Read More

Author(s): Ismail Hussain, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

DOI: 10.5958/2231-5659.2016.00030.8         Access: Open Access Read More

Author(s): K.Vijaya Sri, Guda Santhoshini, D. Ravi Sankar, K.Niharika

DOI: 10.5958/2231-5659.2018.00005.X         Access: Open Access Read More

Author(s): Nikunja B. Pati, T. Swayam Jyothi, Gajender Singh Thakur, Sushma Reddy, G. Meghna

DOI: 10.5958/2231-5659.2017.00028.5         Access: Open Access Read More

Author(s): Sana Banu, Syeda Ayesha Farheen

DOI: 10.5958/2231-5659.2019.00015.8         Access: Closed Access Read More

Author(s): Pramod Patil, Someshwara Rao B, Suresh V Kulkarni, Basavaraj, Chetan Surpur , Anand Ammanage

DOI:         Access: Open Access Read More

Author(s): Dasari Nirmala, Enjamuri Aslesha , M. Sudhakar

DOI:         Access: Open Access Read More

Author(s): D.M. Shinkar, Aarif S. Khatik, R.B. Saudagar

DOI: 10.5958/2231-5659.2016.00022.9         Access: Open Access Read More

Author(s): Smita S. Aher, Poonam R. Songire, Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00031.X         Access: Open Access Read More

Author(s): Lankesh P. Shewale, Sheetal B. Gondkar, Ravindra B. Saudagar, Avinash B. Dareker

DOI: 10.5958/2231-5659.2016.00028.X         Access: Open Access Read More

Author(s): Viral Patel

DOI:         Access: Open Access Read More

Author(s): Raut Indrayani D., Bandgar Sandip A., Shah R. R., Chougule D.D.

DOI:         Access: Open Access Read More

Author(s): V Jhansipriya Marabathuni, P. Dinesh, R. Ravikumar, P. Yamini, P. Sai Kiran, Sd. P.Hussain, Ch. M.M. Prasada Rao

DOI: 10.5958/2231-5659.2017.00015.7         Access: Open Access Read More

Author(s): Sarika S. Lokhande

DOI: 10.5958/2231-5659.2019.00032.8         Access: Closed Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231-5659 


Recent Articles




Tags