Author(s): G. Vasavi, P. Naga Haritha, B. Chandrashekar

Email(s): harithasunilp@gmail.com

DOI: 10.5958/2231-5659.2018.00021.8   

Address: G. Vasavi, P. Naga Haritha, B. Chandrashekar
Department of Pharmaceutics, St.Pauls college of Pharmacy, Turkayamjal, Hyderabad, Telangana, India.
*Corresponding Author

Published In:   Volume - 8,      Issue - 3,     Year - 2018


ABSTRACT:
In the present research work an attempt was made to prepare and evaluate the transdermal patches of Tramadol HCl, a centrally acting opiod analgesic drug. Formulations were made by using different ratios of rate controlling polymers like Eudragit RL100, hydroxyl propyl methyl cellulose 6 cps and ethyl cellulose. Poly ethylene glycol 400 is used as plasticizer and Tween 80 as penetration enhancer. The patches were prepared by solvent evaporation technique using liquid paraffin as lubricant. The study examines the influence of polymers ratio on physicochemical properties and drug release potential of transdermal films. In the pre formulation studies, solubility, partition coefficient and melting point were determined to assess its application for transdermal delivery. The FTIR studies confirmed that there is no incompatibility present between drug and excipients. The patches were evaluated for their appearance, weight uniformity, and thickness uniformity, drug content uniformity, folding endurance, invitro diffusion and stability studies. Based on the evaluation studies F10 formulation was optimised. The drug release was extended for 12 hrs showing drug release of 94.19%. The release kinetics data for optimised formulation has revealed that the patch is best fit in to higuchi model with fickian type of diffusion. The optimised formulation was subjected to accelerated stability studies for 6 months and the results found to be stable with respect to drug content, drug release as well as physical changes.


Cite this article:
G. Vasavi, P. Naga Haritha, B. Chandrashekar. Formulation Development and In vitro Evaluation of Transdermal Patches of Tramadol HCl. Asian J. Res. Pharm. Sci. 2018; 8(3):123-129. doi: 10.5958/2231-5659.2018.00021.8

Cite(Electronic):
G. Vasavi, P. Naga Haritha, B. Chandrashekar. Formulation Development and In vitro Evaluation of Transdermal Patches of Tramadol HCl. Asian J. Res. Pharm. Sci. 2018; 8(3):123-129. doi: 10.5958/2231-5659.2018.00021.8   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2018-8-3-1


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