Author(s):
Dipali K. Gaikwad, Sushant M. Ahire, Deepak D. Sonwane, Sunil K. Mahajan
Email(s):
dipaligaikwad2109@gmail.com , sushantahire071@gmail.com , sushantahire071@gmail.com , skmahajan2010@rediffmail.com
DOI:
10.52711/2231-5659.2026.00060 
Address:
Dipali K. Gaikwad1, Sushant M. Ahire2, Deepak D. Sonwane3, Sunil K. Mahajan4
1,3Department of Pharmaceutics, Divine College of Pharmacy Satana, Nashik, Maharashtra, India.
2,4Department of Pharmaceutical Chemistry, Divine College of Pharmacy Satana, Nashik, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
Although definitely milk thistle (Silybum marianum) is not a newcomer in terms of being hepatoprotective, the anti-inflammatory effect of its major bioactive constituent, silymarin, has recently found interest as an ingredient in fields of dermatology. This is a case study review of the design and testing of silymarin-impregnated transdermal patches with specific anti-inflammatory properties on the skin. Transdermal delivery is characterized by reduced adverse effects in the system, enhanced absorption, and controlled release of the drug. Many formulation methods, polymers, and permeation enhancers are investigated in order to optimise patch efficiency. In vitro and in vivo analyses of silymarin patches have provided encouraging evidence on their anti-inflammatory properties in the localized inflammation, thus, they may serve as a promising alternative topical intervention in the treatment of inflammatory skin diseases. The current review is based on the formulation issues, effects of milk thistle in the treatment, and potential applications of milk thistle in dermatology.
Cite this article:
Dipali K. Gaikwad, Sushant M. Ahire, Deepak D. Sonwane, Sunil K. Mahajan. Milk Thistle in Dermatology – Development of Silymarin Transdermal Patches for Targeted Anti-inflammatory Action - A Review. Asian Journal of Research in Pharmaceutical Sciences. 2026; 16(4):419-0. doi: 10.52711/2231-5659.2026.00060
Cite(Electronic):
Dipali K. Gaikwad, Sushant M. Ahire, Deepak D. Sonwane, Sunil K. Mahajan. Milk Thistle in Dermatology – Development of Silymarin Transdermal Patches for Targeted Anti-inflammatory Action - A Review. Asian Journal of Research in Pharmaceutical Sciences. 2026; 16(4):419-0. doi: 10.52711/2231-5659.2026.00060 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2026-16-4-13
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