Author(s):
Shivraj Popat Jadhav, Dhanashri Nandale, Nitisha Deore, Madiha Pathan, Sunil Kashinath Mahajan, Deepak Devidas Sonawane, Parag Ashok Pathade
Email(s):
shiva.007ind@gmail.com
DOI:
10.52711/2231-5659.2026.00051 
Address:
Shivraj Popat Jadhav*1, Dhanashri Nandale, Nitisha Deore1, Madiha Pathan1, Sunil Kashinath Mahajan2, Deepak Devidas Sonawane1, Parag Ashok Pathade3
1Department of Pharmaceutics, Divine College of Pharmacy, Satana, Maharashtra, India.
2Department of Pharmaceutical Chemistry, Divine College of Pharmacy, Satana, Maharashtra, India.
3KBHSS Trust’s Institute of Pharmacy, Malegaon, Nashik, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
Background: The demand for natural and eco-friendly skincare products has grown significantly in recent years. Orange peel, a by-product of citrus fruits, is rich in antioxidants and bioactive compounds beneficial for skin health. This study aimed to formulate and evaluate a herbal face serum using orange peel extract for its potential antioxidant and cosmetic benefits. Materials and Methods: The face serum was formulated using orange peel extract, aloe vera gel, glycerine, HPMC, vitamin E, orange oil, and other excipients. Three formulations (F1, F2, F3) were developed and evaluated for key physicochemical properties including pH, viscosity, spreadability, homogeneity, stability, and antioxidant activity. The antioxidant activity was assessed using the DPPH free radical scavenging assay, and the IC50 value was calculated graphically. Results: Among the three formulations, F3 demonstrated optimal characteristics with a pH of 6.4±0.3, viscosity of 247±8.1cP, and spreadability of 6.2±0.2cm. It exhibited excellent homogeneity and physical stability over four weeks. The DPPH assay revealed that F3 showed the highest antioxidant activity, with 71.7% inhibition at 100 µL concentration and an IC50 value of 39.5µL. Conclusion: The formulated orange peel extract-based face serum demonstrated favourable physicochemical properties and significant antioxidant potential, making it a promising candidate for natural cosmetic applications in skincare.
Cite this article:
Shivraj Popat Jadhav, Dhanashri Nandale, Nitisha Deore, Madiha Pathan, Sunil Kashinath Mahajan, Deepak Devidas Sonawane, Parag Ashok Pathade. Formulation and Evaluation of a Natural Antioxidant Face Serum using Orange Peel Extract. Asian Journal of Research in Pharmaceutical Sciences. 2026; 16(4):349-4. doi: 10.52711/2231-5659.2026.00051
Cite(Electronic):
Shivraj Popat Jadhav, Dhanashri Nandale, Nitisha Deore, Madiha Pathan, Sunil Kashinath Mahajan, Deepak Devidas Sonawane, Parag Ashok Pathade. Formulation and Evaluation of a Natural Antioxidant Face Serum using Orange Peel Extract. Asian Journal of Research in Pharmaceutical Sciences. 2026; 16(4):349-4. doi: 10.52711/2231-5659.2026.00051 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2026-16-4-4
8. REFERENCES:
1. Dini I. “Edible Beauty”: The evolution of environmentally friendly cosmetics and packaging. Antioxidants. 2024; 13(6):742.
2. Wirtu YD. A review of environmental and health effects of synthetic cosmetics. Front Environ Sci. 2024; 12:1402893.
3. Munir H, Yaqoob S, Awan KA, et al. Unveiling the chemistry of citrus peel: Insights into nutraceutical potential and therapeutic applications. Foods. 2024; 13(11):1681.
4. Maqbool Z, Khalid W, Atiq HT, et al. Citrus waste as source of bioactive compounds: Extraction and utilization in health and food industry. Molecules. 2023; 28(4):1636.
5. Vaidya S. Review on face serum. Asian J Pharm. 2024; 18(3).
6. Fakayode OA, Abobi KE. Optimization of oil and pectin extraction from orange (Citrus sinensis) peels: A response surface approach. J Anal Sci Technol. 2018; 9:20.
7. Srivastava P, Malviya R. Extraction, characterization and evaluation of orange peel waste derived pectin as a pharmaceutical excipient. Nat Prod J. 2011; 1(1):65-70.
8. Yeskar H, Makde P, Tiware SA, et al. Formulation and evaluation of a face serum containing fenugreek extract. Int J Basic Clin Pharmacol. 2023; 12(6):799-804.
9. Maya I, Sriwidodo S, Mita SR, et al. Formulation and evaluation of facial serum containing Sacha Inchi oil (Plukenetia volubilis L.) from Indonesia as an anti-aging: Stability, in vitro, and skin irritation assessments. Cosmetics. 2024; 11(6):226.
10. Chaudhari MAP, Chaudhari MBV, Patil JK. Formulation and evaluation of herbal anti-aging gel-based face serum from Ficus carica. Int J Res Appl Sci Eng Technol. 2024; 12(5):1362-8.
11. Wasnik V, Bhude P, Ajane P, et al. Formulation and evaluation of herbal face serum for treatment of hyperpigmentation. Res J Top Cosmet Sci. 2024:13-9.
12. Amnuaikit T, Khakhong S, Khongkow P. Formulation development and facial skin evaluation of serum containing jellose from tamarind seeds. J Pharm Res Int. 2019:1-14.
13. Jadhav K, Jadhav S, Sonawane D, et al. Formulation and evaluation of miconazole nitrate-loaded novel nanoparticle gel for topical delivery. J Pharm Res Int. 2021: 292-307.
14. Sharma A, Prasar B. Formulation and evaluation of herbal cosmetic cream to produce multipurpose effect on skin. Res J Top Cosmet Sci. 2013; 4(1):1-4.
15. Baliyan S, Mukherjee R, Priyadarshini A, et al. Determination of antioxidants by DPPH radical scavenging activity and quantitative phytochemical analysis of Ficus religiosa. Molecules. 2022; 27(4):1326.