Author(s): D. Akiladevi, M. Nappinnai, T. Sudha

Email(s): akilaajcp@gmail.com

DOI: 10.5958/2231-5659.2017.00035.2   

Address: D. Akiladevi1*, Dr. M. Nappinnai2, Dr. T. Sudha3
1Asst Professor, Department of Pharmaceutics, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319.Tamilnadu, India.
2Department of Pharmaceutics, School of Pharmacy, Surya Group of Institutions, Vikravandi, Villupuram Dist.605 652. Tamilnadu, India
3Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319.Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 4,     Year - 2017


ABSTRACT:
The present investigation attempted to study the effect of disintegrants and processing methods on the physicochemical and in vitro release characteristics of immediate release tablets of Bosentan Monohydrate. To achieve this goal various formulations of Bosentan Monohydrate were prepared by direct compression, wet granulation and fluidized bed granulation methods to achieve maximum drug content with reference to innovator. Varying proportion of disintegrants such as sodium starch glycolate, pregelatinised starch used to compare drug release profile with innovator. Different formulations were prepared and evaluated with respect to various precompression and post compression parameters. The results indicated that the superdisintegrants used have influenced on the disintegration time. The final selection of the formulation F8 (f2 = 71) containing sodium starch glycolate was based on highest f2 value among all formulations with reference to marketed product.


Cite this article:
D. Akiladevi, M. Nappinnai, T. Sudha. A Study on the Effect of disintegrants and Processing Methods on the Physicochemical and In Vitro Release Characteristics of Immediate Release Tablets of Bosentan Monohydrate. Asian J. Res. Pharm. Sci. 2017; 7(4): 222-226. doi: 10.5958/2231-5659.2017.00035.2


Recomonded Articles:

Author(s): Mohd. Yaqub Khan, Maryada Roy, Imtiyaz Ahmad, Irfan Aziz, Manju Panday

DOI: 10.5958/2231-5659.2015.00024.7         Access: Open Access Read More

Author(s): Mohd. Yaqub Khan, Irfan Aziz, Imtiyaz Ahmad, Bipin Bihari, Hemant Kumar, Manju Panday

DOI:         Access: Open Access Read More

Author(s): Dibyajyoti Saha, Milan Hait, Mayukh Jana, Suprodip Mandal, Utpal Jana

DOI:         Access: Open Access Read More

Author(s): Saudagar R. B., Sarika V. Khandbahale

DOI: 10.5958/2231-5659.2017.00005.4         Access: Open Access Read More

Author(s): Muhammed Jameel VP, Ravikumar, Narayanaswamy VB

DOI: 10.5958/2231-5659.2016.00017.5         Access: Open Access Read More

Author(s): K.Vijaya Sri, Guda Santhoshini, D. Ravi Sankar, K.Niharika

DOI: 10.5958/2231-5659.2018.00005.X         Access: Open Access Read More

Author(s): Nikhil P. Mahalpure , Sheetal B. Gondkar , Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00014.X         Access: Open Access Read More

Author(s): D.M. Shinkar, Rohan S. Gadakh, R.B. Saudagar

DOI: 10.5958/2231-5659.2016.00015.1         Access: Open Access Read More

Author(s): Rohan R. Vakhariya, Swati S. Talokar, V. R. Salunkhe, C. S. Magdum

DOI: 10.5958/2231-5659.2017.00008.X         Access: Open Access Read More

Author(s): Pramod Patil, Someshwara Rao B, Suresh V Kulkarni, Basavaraj, Chetan Surpur , Anand Ammanage

DOI:         Access: Open Access Read More

Author(s): Sana Banu, Syeda Ayesha Farheen

DOI: 10.5958/2231-5659.2019.00015.8         Access: Closed Access Read More

Author(s): J. Kasthuri, A. Cholarajan, R. Vijayakumar, P. Muthukumaran

DOI:         Access: Open Access Read More

Author(s): Li Gun, Tian Han, Guo Rui, Du Ning

DOI: 10.5958/2231-5659.2017.00037.6         Access: Open Access Read More

Author(s): Dasari Nirmala, Enjamuri Aslesha , M. Sudhakar

DOI:         Access: Open Access Read More

Author(s): D.M. Shinkar, Aarif S. Khatik, R.B. Saudagar

DOI: 10.5958/2231-5659.2016.00022.9         Access: Open Access Read More

Author(s): Smita S. Aher, Poonam R. Songire, Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00031.X         Access: Open Access Read More

Author(s): Lankesh P. Shewale, Sheetal B. Gondkar, Ravindra B. Saudagar, Avinash B. Dareker

DOI: 10.5958/2231-5659.2016.00028.X         Access: Open Access Read More

Author(s): Swapnil R. Lahamage, Avinash B. Darekar, Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00008.4         Access: Open Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231-5659 


Recent Articles




Tags