Author(s):
D. Akiladevi, M. Nappinnai, T. Sudha
Email(s):
akilaajcp@gmail.com
DOI:
10.5958/2231-5659.2017.00035.2 
Address:
D. Akiladevi1*, Dr. M. Nappinnai2, Dr. T. Sudha3
1Asst Professor, Department of Pharmaceutics, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319.Tamilnadu, India.
2Department of Pharmaceutics, School of Pharmacy, Surya Group of Institutions, Vikravandi, Villupuram Dist.605 652. Tamilnadu, India
3Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319.Tamilnadu, India.
*Corresponding Author
Published In:
Volume - 7,
Issue - 4,
Year - 2017
ABSTRACT:
The present investigation attempted to study the effect of disintegrants and processing methods on the physicochemical and in vitro release characteristics of immediate release tablets of Bosentan Monohydrate. To achieve this goal various formulations of Bosentan Monohydrate were prepared by direct compression, wet granulation and fluidized bed granulation methods to achieve maximum drug content with reference to innovator. Varying proportion of disintegrants such as sodium starch glycolate, pregelatinised starch used to compare drug release profile with innovator. Different formulations were prepared and evaluated with respect to various precompression and post compression parameters. The results indicated that the superdisintegrants used have influenced on the disintegration time. The final selection of the formulation F8 (f2 = 71) containing sodium starch glycolate was based on highest f2 value among all formulations with reference to marketed product.
Cite this article:
D. Akiladevi, M. Nappinnai, T. Sudha. A Study on the Effect of disintegrants and Processing Methods on the Physicochemical and In Vitro Release Characteristics of Immediate Release Tablets of Bosentan Monohydrate. Asian J. Res. Pharm. Sci. 2017; 7(4): 222-226. doi: 10.5958/2231-5659.2017.00035.2
Cite(Electronic):
D. Akiladevi, M. Nappinnai, T. Sudha. A Study on the Effect of disintegrants and Processing Methods on the Physicochemical and In Vitro Release Characteristics of Immediate Release Tablets of Bosentan Monohydrate. Asian J. Res. Pharm. Sci. 2017; 7(4): 222-226. doi: 10.5958/2231-5659.2017.00035.2 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2017-7-4-8