Author(s): Akshata A. Jain, S. D. Barhate

Email(s): akshatajain1896@gmail.com

DOI: 10.5958/2231-5659.2019.00038.9   

Address: Akshata A. Jain*, Dr. S. D. Barhate
Shri Sureshdada Jain Institute of Pharmaceutical Research, Jamner-424206, Maharashtra, India
*Corresponding Author

Published In:   Volume - 9,      Issue - 4,     Year - 2019


ABSTRACT:
The main objective of this study was to formulate and evaluate the mouth dissolving tablet of rizatriptan benzoate by using natural superdisintegrant. The banana powder was isolated manually by extraction. Various formulations were prepared by direct compression method using different concentration of natural superdisintegrant. The drug and excipients compatibility study was performed by FTIR and the study revealed no interaction between drug and excipients. The DSC of pure drug was carried out. The blend of all formulations were evaluated for various precompression parameters like angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio and were found to be satisfactory. The tablets were evaluated for various parameters like weight variation, thickness, and hardness, friability, wetting time, water absorption ratio, disintegration time, content uniformity and in vitro drug release. The R4 batch containing 8% of dehydrated banana powder shows drug release of 97.15% in 30 min with disintegration time of 15 sec as compared to C4 batch containing 8% of Crospovidone shows drug release of 94.87 % in 30 min with disintegration time of 19 sec. The R4 batch was selected for the optimization of MDT. The 2 factor Central Composite Design was used for the optimization of MDT. The optimized formulation was subjected to stability studies as per ICH guidelines. The formulation was found to be stable with insignificant change in the physical appearance, hardness, disintegration time, drug content and in vitro drug release.


Cite this article:
Akshata A. Jain, S. D. Barhate. Formulation Optimization and Evaluation of Mouth Dissolving Tablet of Rizatriptan Benzoate by using Natural Superdisintegrant. Asian J. Res. Pharm. Sci. 2019; 9(4):245-252. doi: 10.5958/2231-5659.2019.00038.9


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