Author(s): Mayuri B. Patil, Avish D. Maru, Jayshree S. Bhadane

Email(s): mayuripatil252627@gmail.com

DOI: 10.52711/2231-5659.2021.00043   

Address: Mayuri B. Patil*, Avish D. Maru, Jayshree S. Bhadane
Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal- Kalwan, Dist- Nashik-423501.
*Corresponding Author

Published In:   Volume - 11,      Issue - 4,     Year - 2021


ABSTRACT:
The aim of the present study was to design and evaluate bilayer tablets of metformin hydrochloride as sustained release form for the treatment of Type-II diabetes mellitus. The basic aim of any Bi-layer tablet formulation is to separate physically or chemically incompatible ingredients and to produce repeat action or prolonged action of tablet. They are many drugs for treating type-II diabetes. Sulphonyl urea and biguanides are used commonly by a wide section of patients. Melt granulation process was used for the formulation of sustained comprising metformin layer and wet granulation of immediate comprising layer of glimepiride. The precompression studies like bulk density, tapped density, angle of repose, compressible index and post formulation studies includes weight variation, hardness, thickness, friability and dissolution study. The in-vitro release profile of Glimepiride was dissolved within 45 min, and Metformin Hydrochloride was able to release more than 12 hrs. They all the formulation was optimized formula due to its higher rate of dissolution and collate all other parameters with the official specifications.


Cite this article:
Mayuri B. Patil, Avish D. Maru, Jayshree S. Bhadane. Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(4):273-9. doi: 10.52711/2231-5659.2021.00043

Cite(Electronic):
Mayuri B. Patil, Avish D. Maru, Jayshree S. Bhadane. Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(4):273-9. doi: 10.52711/2231-5659.2021.00043   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2021-11-4-3


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