Author(s): Lankesh P. Shewale, Sheetal B. Gondkar, Ravindra B. Saudagar, Avinash B. Dareker

Email(s): lankesh.shewlae99@gmail.com

DOI: 10.5958/2231-5659.2016.00028.X   

Address: Lankesh P. Shewale1*, Sheetal B. Gondkar1, Ravindra B. Saudagar2, Avinash B. Dareker3
1Department of Pharmaceutics, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, India.
2Department of Pharmaceutical Chemistry, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2016


ABSTRACT:
The objective of this study was to design matrix tablets for oral sustained release of clopidogrel bisulfate and to investigate the sustained release behavior of the matrix tablets. Matrices were prepared by direct compression technique, melt method and microencapsulation using sodium carboxymethylcellulose, carnuba wax and ethyl cellulose as a release retardant. The FT-IR analysis indicated the stability and compatibility of drug with excipients. The formulation was optimized on the basis of acceptable tablet properties and invitro drug release. The resulting formulations produced tablets with optimum hardness, uniform thickness, consistent weight uniformity and low friability. The results of dissolution studies indicated that formulations F2 batch exhibited good drug release pattern to provide sufficient concentration for achieving satisfactory therapeutic value for extended period of time. The drug release from F2 formulation was sustained upto 12 hrs. Tablet Fitting in-vitro drug release data from optimized matrix formulation to Korsmeyer Pappas model equation indicated that diffusion and erosion could be mechanism of drug release. Matrix tablet F2 showed no change in physical appearance, drug content after storage 400C, 75% RH for 3 months.


Cite this article:
Lankesh P. Shewale, Sheetal B. Gondkar, Ravindra B. Saudagar, Avinash B. Dareker. Formulation Development and Comparative Study of Clopidogrel Bisulfate Matrix Formulations. Asian J. Res. Pharm. Sci. 2016; 6(3): 167-176. doi: 10.5958/2231-5659.2016.00028.X


Recomonded Articles:

Author(s): Ismail Hussain, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

DOI: 10.5958/2231-5659.2016.00030.8         Access: Open Access Read More

Author(s): K.Vijaya Sri, Guda Santhoshini, D. Ravi Sankar, K.Niharika

DOI: 10.5958/2231-5659.2018.00005.X         Access: Open Access Read More

Author(s): Pramod Patil, Someshwara Rao B, Suresh V Kulkarni, Basavaraj, Chetan Surpur , Anand Ammanage

DOI:         Access: Open Access Read More

Author(s): Smita S. Aher, Poonam R. Songire, Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00031.X         Access: Open Access Read More

Author(s): Lankesh P. Shewale, Sheetal B. Gondkar, Ravindra B. Saudagar, Avinash B. Dareker

DOI: 10.5958/2231-5659.2016.00028.X         Access: Open Access Read More

Author(s): Viral Patel

DOI:         Access: Open Access Read More

Author(s): Keerti Shrivastava, Sherendra Sahu, Skand K. Mishra, Kantishree De

DOI:         Access: Open Access Read More

Author(s): Smita Kolhe, Praveen Chaudhari, Dhananjay More

DOI:         Access: Open Access Read More

Author(s): Pradnya M. Khandagale, Bhushan Bhairav, R.B. Saudagar

DOI: 10.5958/2231-5659.2017.00010.8         Access: Open Access Read More

Author(s): Pramodaganta, Ashok kumar P, Surendrabhoopathi. G, Suresh V. Kulakarni

DOI:         Access: Open Access Read More

Author(s): Soujanya Kumari, Ravi Kumar, Yamunappa, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/2231-5659.2016.00001.1         Access: Open Access Read More

Author(s): J. Ravi Kumar Reddy, Y. Indira Muzib, K. P. R. Chowdary

DOI:         Access: Open Access Read More

Author(s): Sarika S. Lokhande

DOI: 10.5958/2231-5659.2019.00032.8         Access: Closed Access Read More

Author(s): G. Vasavi, P. Naga Haritha, B. Chandrashekar

DOI: 10.5958/2231-5659.2018.00021.8         Access: Open Access Read More

Author(s): N. Naidu, G. Sudheer Kumar, K. Sivakrishna, K. Anjinaik, L. Praveen Kumar, G. Sneha

DOI: 10.5958/2231-5659.2017.00017.0         Access: Open Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231-5659 


Recent Articles




Tags