Author(s): Shankar B. Kalbhare, Mandar J. Bhandwalkar, Rohit K. Pawar, Abhirup R. Sagre

Email(s): kirankal786@gmail.com

DOI: 10.5958/2231-5659.2020.00029.6   

Address: Shankar B. Kalbhare1*, Mandar J. Bhandwalkar1, Rohit K. Pawar1, Abhirup R. Sagre2
1Department of Pharmaceutics, YSPM’s Yashoda Technical Campus, Faculty of Pharmacy, Wadhe Satara- 415001 Dist-Satara (M.S.) India.
2Department of Pharmacology, YSPM’s Yashoda Technical Campus, Faculty of Pharmacy, Wadhe Satara- 415001 Dist-Satara (M.S.) India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2020


ABSTRACT:
The Oral controlled drug delivery system represent the most popular form of sustain drug delivery system for the obvious advantages of oral route of drug administration. Such systems release the drug with constant or variable release rates. The oral controlled release system show a typical pattern of drug release in which the drug concentration is maintain in the therapeutic windows for prolonged period of time (sustain release), there by insuring sustained therapeutic action. They are used as single dosage form. ?Max of losartan potassium was found to be at 205.3 nm. All formulation of Losartan potassium micro beads showed the particle size between 0.61 to 0.77mm. The lowest % entrapment efficiency was obtained in formulation F1 and highest was found to be formulation F3. The result demonstrated that effect on % entrapment efficiency with in decreasing concentration of sodium alginate. The drug releases of F 1, F 2 and F 3 formulations is found to be 50.2% to 98.52%, 49.21% to 98.23% and 43.21% to 98.52% respectively. Among all formulations, F 3 was show maximum drug release i.e. 98.51% after 12 hr. It was observed that extent of drug release is attributed to the increase in amount of sodium alginate. All the formulation of microbeads produced the optimum swelling ratio in the range 156-267. The minimum swelling ratio of formulation F1 and higher swelling ratio of formulation F3 is observed. Present work involves preparation and evaluation of sustained release of microbeads of losartan potassium employing sodium alginate as natural polymer. The technique employed for microencapsulation of the drug is ion tropic gelatin.


Cite this article:
Shankar B. Kalbhare, Mandar J. Bhandwalkar, Rohit K. Pawar, Abhirup R. Sagre. Sodium Alginate cross-linked Polymeric Microbeads for oral Sustained drug delivery in Hypertension: Formulation and Evaluation. Asian J. Res. Pharm. Sci. 2020; 10(3):153-157. doi: 10.5958/2231-5659.2020.00029.6


REFERENCES:
1. Lachman L, Liberman H, Kanig J. The Theory and Practice of Industrial Pharmacy. 3rd ed. Mumbai: Varghese Publishing House, 1986, p. 430.
2. Gibaldi M, Parrier D. Biopharmaceutics and clinical Pharmacokinetics. Philadelphia: Lea and Febiger 3rd ed., Vol 15,1984,64-82.
3. Belyaeva E, Valle D.D., Neufeld R.J. Ponceleta D. New approach to the formulation of hydrogel beads by emulsification/thermal gelation using a static mixer. Chem Eng Sci 2004; 59(2): 2913–20.
4. Ogaji IJ, Nep EI, Audu-Peter JD. Advances in Natural Polymers as Pharmaceutical Excipients. Pharm Anal Acta. 2012;03(01):1–16.
5. Balwierz R, Jankowski A, Jasińska A, Marciniak D, Pluta J. Formulation and evaluation of microspheres containing losartan potassium by spray-drying technique. Acta Pol Pharm - Drug Res. 2016;73(5):1275–86. 
6. Aglawe Sachin B. Gayke A. U., Metkar P. S., Sancheti V.P., Palghadmal P.S. MRS. Formulation and Evaluation of Losartan Potassium Microspheres By. Indo Am J Pharm Res. 2017;7(09):735–43. 
7. Ramalingam N, Binulal C, Palanivelu M, Ganesan B, Dt M. Preparation and evaluation of losartan potassium. 2018;7(7):1098–115. 
8. Badarinath A.V., Reddy J.R. Mallikarjuna R K. Alagusundaram M, Gnanaprakash K., Chetty M. S. Formulation and Characterization of Alginate Microbeads of Flurbiprofen by Ionotropic Gelation  Techniques.  Int J Chem Tech Res 2010;2(1):361-367.
9. Reddy T., Tammishetty S. Formulation of barium chloride crosslinked beads of carboxymethyl guar gum. J Applied Poly Sci 2001; 82(7): 3084-3090.
10. Bopanna R., Kulkarni R.V., Setty C.M. Carboxymethylcellulose-aluminium hydrogelmicrobeads for prolong release of Simvastatin. Acta Pharm Sci 2010; 52(2): 137-143.
11. Elzatahry A.A., Soliman E.A. Evaluation of alginatechitosan bioadhesive beads as a drug delivery system for the controlled release of Theophylline, J Apppl Poly Sci 2009; 111(34): 2452-2459.
12. Gursoy A., Cevik S. Sustained release properties of alginate microsphere and tableted microsphere of diclofenac sodium, J Microencapsul 2000; 17(4): 565-575.
13. Beckett AH, Alternative routes of drug administration and new drug delivery systems: Towards better safety of drug and pharmaceutical products. North Holland: Elsevier North Holland Biomedical Press, 1980;247-263.
14. Devis SS, Hardy JG, Taylor MJ, Whalley DR and Wilson CG. Comparative study of gastrointestinal transit of a pellet and tablet formulation. Int J Pharm. 1984; 21:167-177.
15. Follonier N and Doelkar E., Biopharmaceutical comparison of oral multiple-unit and single-unit sustained release dosage forms. STP Pharmaceutical Sciences. 1992; 2:141- 158.
16. Lym-Ly and Wan-LS. Propranolol Binding in Calcium Alginate Beads. Drug Develop Indi. Pharm. 1997; 23(10):973-980.
17. Manna A, Ghosh I, Goswami N, Ghosh LK and Gupta BK. Design and evaluation of an oral controlled Release Microparticulate Drug Delivery system of Nimesulide by Ionotropic Gelation Technique and Statistical Optimization by Factorial Analysis. J Sci Ind Res. 1999; 58(9):717-722.
18. Patil VB and Varsha B. Preparation and Evaluation of Sustained Release Nimesulide Microbeads prepared from sodium alginate. Indian J Pharm Sci. 2001;63(1):15-19.
19. Chowdary KPR and Srinivasa Rao Y. Preparation and Evaluation of Mucoadhesive Microparticles of Indomethacin. Indian J Pharma Sci. 2003;65(1):49-52
20. Nikhil O, Dhoot and Margaret A. ‘Microencapsulated Liposomes in Controlled Drug Delivery: Strtegies to Modulate Drug Release and Eliminate the Burst Effect. J Pharm Sci. 2003;92(3): 679-689.
21. Chowdary KPR and Srinivasa Rao Y. Mucoadhesive Microparticles of Glipizide; Characterization, In-vitro and In-vivo Evaluation. Indian J Pharm Sci. 2003;65(3):279- 284.
22.   Srineevasa Rao B and Ramana Murthy KV. Preparation and evaluation of flurviprofen Microcapsules by Emulsification Solvent Evaporation Technique’. Indian Drugs, 1996; 33(8); 397-400.

Recomonded Articles:

Author(s): Lakshmi Prasanna J., Deepthi B., Rama Rao N.

DOI:         Access: Open Access Read More

Author(s): Saudagar R. B., Sarika V. Khandbahale

DOI: 10.5958/2231-5659.2017.00005.4         Access: Open Access Read More

Author(s): Yogita R. Indalkar, Nayana V. Pimpodkar, Puja S. Gaikwad, Anita S. Godase

DOI: 10.5958/2231-5659.2016.00010.2         Access: Open Access Read More

Author(s): AK Mohiuddin

DOI: 10.5958/2231-5659.2019.00004.3         Access: Closed Access Read More

Author(s): Pratibha Gavarkar, Pramod Patil, Akshay Sutar, Shridhar Rasal, Dyaneshwar Surwase

DOI: 10.5958/2231-5659.2016.00029.1         Access: Open Access Read More

Author(s): Pramod Patil, Someshwara Rao B, Suresh V Kulkarni, Basavaraj, Chetan Surpur , Anand Ammanage

DOI:         Access: Open Access Read More

Author(s): Sana Banu, Syeda Ayesha Farheen

DOI: 10.5958/2231-5659.2019.00015.8         Access: Closed Access Read More

Author(s): Roshani Bhalerao, Akshay Patil, Dinesh Rishipathak, Sanjay Kshirsagar

DOI: 10.5958/2231-5659.2017.00029.7         Access: Open Access Read More

Author(s): Aduema W., Amah A. K, Wariso A.C

DOI: 10.5958/2231-5659.2018.00001.2         Access: Open Access Read More

Author(s): Rajendra Jangde

DOI:         Access: Open Access Read More

Author(s): Sourabh S. Baghel, Sonal Dangi, Prashant Soni, Priya Singh, Yogesh Shivhare

DOI:         Access: Open Access Read More

Author(s): Dasari Nirmala, Enjamuri Aslesha , M. Sudhakar

DOI:         Access: Open Access Read More

Author(s): D.M. Shinkar, Aarif S. Khatik, R.B. Saudagar

DOI: 10.5958/2231-5659.2016.00022.9         Access: Open Access Read More

Author(s): Smita S. Aher, Poonam R. Songire, Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00031.X         Access: Open Access Read More

Author(s): Mohammad Yaqub Khan, Irfan Aziz, Imtiyaz Ahmad, Maryada Roy

DOI: 10.5958/2231-5659.2015.00029.6         Access: Open Access Read More

Author(s): Lankesh P. Shewale, Sheetal B. Gondkar, Ravindra B. Saudagar, Avinash B. Dareker

DOI: 10.5958/2231-5659.2016.00028.X         Access: Open Access Read More

Author(s): S. More, T. Ghadge, S. Dhole

DOI:         Access: Open Access Read More

Author(s): Surekha Baghel, Bina Gidwani, Chanchal Deep Kaur

DOI: 10.5958/2231-5659.2017.00009.1         Access: Open Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231-5659 


Recent Articles




Tags