Author(s): Subhashis Debnath, T. H. Harish Kumar

Email(s): sdebnath@rgu.ac

DOI: 10.5958/2231-5659.2020.00023.5   

Address: Subhashis Debnath1*, T. H. Harish Kumar2
1Royal School of Pharmacy, The Assam Royal Global University, Guwahati, Assam, India
2Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 2,     Year - 2020


ABSTRACT:
Pharmacokinetics is proposed to study the absorption, distribution, biotransformation and elimination of drugs in man and animals. A more careful description of the data can be obtained interpolating and extrapolating the drug concentrations with some mathematical functions. These functions may be used to reduce all the data in a small set of parameters, or to verify if the hypotheses incorporated in the functions are confirmed by the observations. In the first case, we can say that the task is to get a simulation of the data, in the second to get a model. The functions used to interpolate and reduce the pharmacokinetic data are the multiexponential functions and the reference models are the compartmental models whose solutions are just the multiexponential functions. Using models, new meaningful pharmacokinetic parameters may be defined which can be used to find relationships between the drug kinetic profile and the physiological process which drive the drug absorption, distribution and elimination. For example, compartmental models allow to define easily the clearance which is dependent on the drug elimination process, or the volume of distribution which depends on the drug distribution in the tissues. Models provide also an easy way to get an estimate of drug absorption after extra vascular drug administration (bioavailability). Model building is a complex multistep process where, experiment by experiment and simulation by simulation, new hypothesis are proven and disproven through a continuous interaction between the experimenter and the computer.


Cite this article:
Subhashis Debnath, T. H. Harish Kumar. An Overview on Pharmacokinetics and Pharmacokinetic Modeling. Asian J. Res. Pharm. Sci. 2020; 10(2):124-130. doi: 10.5958/2231-5659.2020.00023.5


Recomonded Articles:

Author(s): Lakshmi Prasanna J., Deepthi B., Rama Rao N.

DOI:         Access: Open Access Read More

Author(s): Rajashri R. Kulkarni, Dipti G. Phadtare, Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00019.9         Access: Open Access Read More

Author(s): Saudagar R. B., Sarika V. Khandbahale

DOI: 10.5958/2231-5659.2017.00005.4         Access: Open Access Read More

Author(s): AK Mohiuddin

DOI: 10.5958/2231-5659.2019.00004.3         Access: Closed Access Read More

Author(s): Ismail Hussain, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

DOI: 10.5958/2231-5659.2016.00030.8         Access: Open Access Read More

Author(s): Ameena Samreen, Mohammed Riyaz, Amtul Asiya, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5659.2017.00007.8         Access: Open Access Read More

Author(s): Girishchandra R. Mandake, Indrajit S. Patil, Omkar A Patil, Manoj M. Nitalikar, Shriniwas K Mohite

DOI: 10.5958/2231-5659.2018.00012.7         Access: Open Access Read More

Author(s): Pratibha Gavarkar, Pramod Patil, Akshay Sutar, Shridhar Rasal, Dyaneshwar Surwase

DOI: 10.5958/2231-5659.2016.00029.1         Access: Open Access Read More

Author(s): Pramod Patil, Someshwara Rao B, Suresh V Kulkarni, Basavaraj, Chetan Surpur , Anand Ammanage

DOI:         Access: Open Access Read More

Author(s): Sana Banu, Syeda Ayesha Farheen

DOI: 10.5958/2231-5659.2019.00015.8         Access: Closed Access Read More

Author(s): Roshani Bhalerao, Akshay Patil, Dinesh Rishipathak, Sanjay Kshirsagar

DOI: 10.5958/2231-5659.2017.00029.7         Access: Open Access Read More

Author(s): Aduema W., Amah A. K, Wariso A.C

DOI: 10.5958/2231-5659.2018.00001.2         Access: Open Access Read More

Author(s): Shiba S. Morris, Jeyabalan G, A. K. Jha, Shekhar Verma, Yashwant Swarnkar

DOI:         Access: Open Access Read More

Author(s): Rajendra Jangde

DOI:         Access: Open Access Read More

Author(s): Sourabh S. Baghel, Sonal Dangi, Prashant Soni, Priya Singh, Yogesh Shivhare

DOI:         Access: Open Access Read More

Author(s): D.M. Shinkar, Aarif S. Khatik, R.B. Saudagar

DOI: 10.5958/2231-5659.2016.00022.9         Access: Open Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231-5659 


Recent Articles




Tags