Author(s):
Chetan J. Girase, Hemant V. Deore
Email(s):
chetanjgirase1525@gmail.com , hemantdeore24@gmail.com
DOI:
10.52711/2231-5659.2025.00062 
Address:
Chetan J. Girase1, Hemant V. Deore2
1Research Scholar, DCS’S A.R.A. College of Pharmacy, Nagaon, Dhule.
2Associate Professor, DCS’S A.R.A. College of Pharmacy, Nagaon, Dhule.
*Corresponding Author
Published In:
Volume - 15,
Issue - 4,
Year - 2025
ABSTRACT:
This review critically analyzes current insights into the pathogenesis and diagnostics of urolithiasis from molecular, genetic, and clinical viewpoints. Urolithiasis, affecting 1–15% of the global population, results from imbalances between urinary crystallization promoters (e.g., calcium, oxalate) and inhibitors (e.g., citrate, magnesium), leading to stone formation. Five main theories explain its mechanisms: Free Particle and Fixed Particle Theories, Randall’s Plaque Hypothesis, the Blocked Lymphatic Theory, and the Vascular Theory. Modern understanding highlights its polyetiological nature, involving genetic polymorphisms (e.g., VDR, ORAI1, CASR) and environmental factors. Diagnostic methods include urine and serum analysis, stone composition techniques (e.g., infrared spectroscopy), and imaging—ranging from ultrasound to CT. Emerging tools like parametric MRI and biomarker detection offer improved specificity. A personalized diagnostic approach, integrating metabolic, genetic, and imaging data, is essential for effective treatment and prevention of this complex condition.
Cite this article:
Chetan J. Girase, Hemant V. Deore. Modern Pathogenetic Aspects and Updates on Diagnostic Modalities of Urolithiasis Development: A Review. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(4):418-2. doi: 10.52711/2231-5659.2025.00062
Cite(Electronic):
Chetan J. Girase, Hemant V. Deore. Modern Pathogenetic Aspects and Updates on Diagnostic Modalities of Urolithiasis Development: A Review. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(4):418-2. doi: 10.52711/2231-5659.2025.00062 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2025-15-4-12
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