Author(s): Gitanjalee C. Shimpi, Pushparaj R. Patil

Email(s): gitanjaleeshimpi2001@gmail.com

DOI: 10.52711/2231-5659.2023.00013   

Address: Gitanjalee C. Shimpi, Pushparaj R. Patil
Prof. Ravindra Nikam College of Pharmacy, Dhule, Maharashtra.
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2023


ABSTRACT:
Rosinidin is an O-methylated anthocyanidin derived from Cyanidin. It is a pigment found in the flowers of Catharanthus roseus and, in lower concentration, in Primula rosea. The molecular docking studies predicted that rosinidin has adequate structural competency, making it a viable medicinal candidate for the treatment of a wide range of disorders. The current study intends to assess rosinidin nephroprotective efficacy against nephrotoxicity induced by cisplatin in rats. nephrptoxicity is most serious side effect. This toxicity caused by free radicals. This free radicals damage Renal Tubule which is overcome by Rosinidin. Materials and Methods: Oral acute toxicity tests of rosinidin were conducted to assess potential toxicity in animals, and it was shown to be safe. The nephroprotective effect of rosinidin 10, and 20 mg/kg were tested in rats for 25 days with concurrent administration of cisplatin. Several biochemical parameters were measured to support enzymatic and non-enzymatic oxidative stress such as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH). Likewise, changes in several non-protein-nitrogenous components and blood chemistry parameters were made to support the theory linked with the pathogenesis of chemical-induced nephrotoxicity. Results: Cisplatin caused significant changes in biochemical, enzymatic, and blood chemistry, which rosinidin efficiently controlled. Conclusions: The present investigation linked rosinidin with nephroprotective efficacy in experimental models.


Cite this article:
Gitanjalee C. Shimpi, Pushparaj R. Patil. Protective effect of Rosinidin on Cisplatin-Induced Nephrotoxicity. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(1):69-2. doi: 10.52711/2231-5659.2023.00013

Cite(Electronic):
Gitanjalee C. Shimpi, Pushparaj R. Patil. Protective effect of Rosinidin on Cisplatin-Induced Nephrotoxicity. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(1):69-2. doi: 10.52711/2231-5659.2023.00013   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2023-13-1-13


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