Author(s):
Dimpal R. Sarkar, Neha D. Naringe, Pankaj Dhapke, Nitin Padole, Nilakshi Dhoble, Jagdish R. Baheti
Email(s):
dimpalsarkar143@gmail.com
DOI:
10.52711/2231-5659.2026.00019 
Address:
Dimpal R. Sarkar*, Neha D. Naringe, Pankaj Dhapke, Nitin Padole, Nilakshi Dhoble, Jagdish R. Baheti
Kamla Nehru College of Pharmacy, Butibori, RTMNU University, Nagpur, Maharashtra, India – 441108.
*Corresponding Author
Published In:
Volume - 16,
Issue - 2,
Year - 2026
ABSTRACT:
The eye is a complicated organ with a number of defense mechanisms and barriers. The provision of vital medications via the proper delivery channels and vehicles is crucial because this organ is susceptible to a variety of infections, hereditary abnormalities, and visual impairments. Due to low medication absorption, the most popular method of administration—topical—may not be as effective as it may be. Nanocarrier-based medication delivery systems of the latest generation are safe, efficient, and targeted, and they can get beyond restrictions brought on by the intricate structure of the eye. Nanotechnology actively participates in ophthalmology and ocular medication delivery systems through a variety of nanoparticles, including niosomes, liposomes, micelles, dendrimers, and other polymeric vesicles. Because of their affordability and storage durability, niosomes—non-ionic surfactant vesicles—are becoming popular nanocarriers in drug delivery applications. A hydrating mixture of cholesterol and non-ionic surfactants self-assembles to produce niosomes. As a result, another name for them is non-ionic surfactant vesicles (NSVs). Niosomes are non-toxic, non-immunogenic, non-carcinogenic, and biodegradable. The niosome, its nature, preparation techniques, and niosome-based therapeutic approaches for ocular diseases are all covered in this review. problems with ocular drug administration, methods for enhancing ocular bioavailability, uses, benefits and drawbacks, latest research, and hopes for niosomal drug delivery systems in the future.
Cite this article:
Dimpal R. Sarkar, Neha D. Naringe, Pankaj Dhapke, Nitin Padole, Nilakshi Dhoble, Jagdish R. Baheti. A Review on Niosome in Ocular Drug Delivery System and Their Current Approaches. Asian Journal of Research in Pharmaceutical Sciences.2026; 16(2):117-5. doi: 10.52711/2231-5659.2026.00019
Cite(Electronic):
Dimpal R. Sarkar, Neha D. Naringe, Pankaj Dhapke, Nitin Padole, Nilakshi Dhoble, Jagdish R. Baheti. A Review on Niosome in Ocular Drug Delivery System and Their Current Approaches. Asian Journal of Research in Pharmaceutical Sciences.2026; 16(2):117-5. doi: 10.52711/2231-5659.2026.00019 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2026-16-2-4
REFERENCES:
1. Urtti A. Challenges and obstacles of ocular pharmacokinetics and drug delivery. Advanced Drug Delivery Reviews. 2006 Nov 15; 58(11):1131-1135. DOI: 10.1016/j.addr.2006.07.027
2. Lajunen, T.; Nurmi, R.; Kontturi, L.; Viitala, L.; Yliperttula, M.; Murtomaki, L.; Urtti, A. Light activated liposomes: Functionality and prospects in ocular drug delivery. J. Control. Release 2016, 244, 157–166. DOI: 10.1016/j.jconrel.2016.08.024
3. Del Amo, E.M.; Urtti, A. Current and future ophthalmic drug delivery systems. A shift to the posterior segment. Drug Discov. Today 2008, 13, 135–143. DOI: 10.1016/j.drudis.2007.11.002
4. Yetisgin, A.A.; Cetinel, S.; Zuvin, M.; Kosar, A.; Kutlu, O. Therapeutic Nanoparticles and Their Targeted Delivery Applications. Molecules 2020, 25, 2193. DOI: 10.3390/molecules25092193
5. Sharaf, M.G.; Cetinel, S.; Heckler, L.; Damji, K.; Unsworth, L.; Montemagno, C. Nanotechnology-Based Approaches for Ophthalmology Applications: Therapeutic and Diagnostic Strategies. Asia Pac. J. Ophthalmol. (Phila) 2014, 3, 172–180. DOI: 10.1097/APO.0000000000000059
6. Vaddavalli PK, Garg P, Sharma S, Sangwan VS, Rao GN, Thomas R. Role of confocal microscopy in the diagnosis of fungal and acanthamoeba keratitis. Ophthalmology. 2011 Jan 1; 118(1):29-35. DOI: 10.1016/j.ophtha.2010.05.018
7. Kaur IP, Rana C, Singh H. Development of effective ocular preparations of antifungal agents. Journal of Ocular Pharmacology and Therapeutics. 2008 Oct 1; 24(5):481-94. DOI: 10.1089/jop.2008.0031
8. Rodrigues GA, Lutz D, Shen J, Yuan X, Shen H, Cunningham J, Rivers HM. Topical drug delivery to the posterior segment of the eye: addressing the challenge of preclinical to clinical translation. Pharmaceutical Research. 2018 Dec; 35(12):245.DOI: 10.1007/s11095-018-2519-x
9. Yeo PL, Lim CL, Chye SM, Ling AP, Koh RY. Niosomes: a review of their structure, properties, methods of preparation, and medical applications. Asian Biomedicine. 2017 Aug 1; 11(4):301-314. DOI: https://doi.org/10.1515/abm-2018-0002
10. Amoabediny, G., Haghiralsadat, F., Naderinezhad, S., Helder, M. N., Akhoundi Kharanaghi, E., Mohammadnejad Arough, J., & Zandieh-Doulabi, B. Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review. International Journal of Polymeric Materials and Polymeric Biomaterials. 2017; 67(6), 383–400. https://doi.org/10.1080/00914037.2017.1332623
11. Katrolia A, Chauhan SB, Shukla VK. Formulation and evaluation of metformin hydrochloride-loaded curcumin–lycopene niosomes. SN Applied Sciences. 2019 Dec; 1:1-6. DOI: https://doi.org/10.1007/s42452-019-1768-6
12. Bhardwaj P, Tripathi P, Gupta R, Pandey S. Niosomes: A review on niosomal research in the last decade. Journal of Drug Delivery Science and Technology. 2020 Apr 1; 56: 101581. DOI: https://doi.org/10.1016/j.jddst.2020.101581
13. Gharbavi M, Amani J, Kheiri-Manjili H, Danafar H, Sharafi A. Niosome: A Promising Nanocarrier for Natural Drug Delivery through Blood-Brain Barrier. Advanced Pharmacology of Science. 2018: 1-6. DOI: https://doi.org/10.1155/2018/6847971
14. Sharma Rajni, DuaJagdeep Singh, Prasad D.N, Hira Shabnam, Monika. Advancement in Novel Drug Delivery System: Niosomes. Journal of Drug Delivery & Therapeutics. 2019; 9(3-s):995-1001. DOI: 10.22270/jddt.v9i3-s.2931
15. Kaul S, Gulati N, Verma D, Mukherjee S, Nagaich U. Role of nanotechnology in cosmeceuticals: a review of recent advances. Journal of Pharmaceutics. 2018; 2018(1):3420204. DOI: 10.1155/2018/3420204
16. Arshad, N., Shaheen, F., Khan, I. N., Naeem, S., Riaz, M., Siddique, M. I., Waqar, M. A. A comprehensive review on niosomes: novel manufacturing techniques, factors influencing formation, applications and recent advances. International Journal of Polymeric Materials and Polymeric Biomaterials. 2024:1–18. https://doi.org/10.1080/00914037.2024.2426611
17. Liga S, Paul C, Moacă E-A, Péter F. Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy. Pharmaceutics. 2024; 16(2):223. DOI: https://doi.org/10.3390/pharmaceutics16020223
18. Ge X, Wei M, He S, Yuan WE. Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery. Pharmaceutics. 2019 Jan 29; 11(2):55. DOI: 10.3390/pharmaceutics11020055 .
19. Kaur P, Rani R, Singh AP, Singh AP, An Overview of Niosomes, Journal of Drug Delivery and Therapeutics. 2024; 14(3):137-146. DOI: http://dx.doi.org/10.22270/jddt.v14i3.6450
20. González-Rodríguez ML, AM Rabasco. Charged liposomes as carriers to enhance the permeation through the skin. Expert Opinion on Drug Delivery.2011; 8(7): 857- 871. DOI: https://doi.org/10.1517/17425247.2011.574610
21. Shewaiter MA, Selim AA, Moustafa YM, Gad S, Rashed HM. Radioiodinated acemetacin loaded niosomes as a dual anticancer therapy. International Journal of Pharmaceutics. 2022 Nov 25; 628: 122345. DOI: 10.1016/j.ijpharm.2022.122345
22. Uchegbu I, Vyas S. Non-ionic surfactant-based vesicles (niosomes) in drug delivery. International Journal of Pharmaceutics. 1998; 172(2):33–70. DOI: https://doi.org/10.1016/S0378-5173(98)00169-0
23. Baillie A, Coombs G, Dillan G, Laurio J. Non-ionic surfactant vesicles, niosomes as a delivery system for the anti-leishmanial rug Sodium stibogluconate. Journal of Pharmacy and Pharmacology. 1980; 38(2):502. DOI: https://doi.org/10.1111/j.2042- 7158.1986.tb04623.x
24. Moammeri A, Chegeni MM, Sahrayi H, Ghafelehbashi R, Memarzadeh F, Mansouri A, Akbarzadeh I, Abtahi MS, Hejabi F, Ren Q. Current advances in niosomes applications for drug delivery and cancer treatment. Materials Today Bio. 2023 Dec 1; 23: 100837. DOI https://doi.org/10.1016/j.mtbio.2023.100837
25. Prabhu, kumar R, Koland, dhondge, Preparation and evaluation of nanovesicles of Brominide tartrate, Journal of Young Pharmacist. 2010; 2(4): 356-361. DOI: https://doi.org/10.4103/0975-1483.71623
26. Indu pal K, Manjit S, Meenakshi K. Formulation and evaluation of ophthalmic preparations of acetazolamide, International Journal of Pharmaceutics. 1999: 119-127. DOI: https://doi.org/10.1016/S0378-5173(00)00359-8
27. Ma A, Stephanie WY, Wong JK. Micropulse laser for the treatment of glaucoma: a literature review. Survey of ophthalmology. 2019 Jul 1; 64(4): 486-97. DOI: https://doi.org/10.1016/j.survophthal.2019.01.001
28. Bourcier T, Sauer A, Dory A, Denis J, Sabou M. Fungal keratitis. Journal Francais D'ophtalmologie. 2017 Nov 1; 40(9): e307-13. DOI: 10.1016/j.jfo.2017.08.001
29. McClements ME, MacLaren RE. Gene therapy for retinal disease. Translational Research. 2013 Apr 1; 161(4):241-54. DOI: 10.1016/j.trsl.2012.12.007
30. Gugleva V, Titeva S, Rangelov S, Momekova D. Design and in vitro evaluation of doxycycline hyclate niosomes as a potential ocular delivery system. International Journal of Pharmaceutics. 2019 Aug 15; 567, 118431. DOI: 10.1016/j.ijpharm.2019.06.022
31. Lambert G, Guilatt RL. Current ocular drug delivery challenges. Drug Dev Report Industry Overview Deals. 2005; 33: 1-2. DOI: https://doi.org/10.3390/pharmaceutics15010205
32. Lang JC. Ocular drug delivery conventional ocular formulations. Advanced Drug Delivery Reviews. 1995 Aug 1; 16(1):39-43. DOI: https://doi.org/10.1016/0169-409X(95)00012-V
33. Saettone MF, Giannaccini B, Ravecca S, La Marca F, Tota G. Polymer effects on ocular bioavailability—the influence of different liquid vehicles on the mydriatic response of tropicamide in humans and in rabbits. International Journal of Pharmaceutics. 1984 Jan 1; 20(1-2):187-202. DOI: https://doi.org/10.1016/0378-5173(84)90229-1
34. Baranowski P, Karolewicz B, Gajda M, Pluta J. Ophthalmic drug dosage forms: characterisation and research methods. The Scientific World Journal. 2014; 2014(1):861904. DOI: 10.1155/2014/861904
35. Sahoo SK, Dilnawaz F, Krishnakumar S. Nanotechnology in ocular drug delivery. Drug Discovery Today. 2008 Feb 1; 13(3- 4):144-51. DOI: https://doi.org/10.1016/j.drudis.2007.10.021