Author(s):
Jorige Archana, Kanthala Sanghavi, Deekonda Sanjana
Email(s):
archanacology@gmail.com
DOI:
10.52711/2231-5659.2026.00017 
Address:
Jorige Archana*, Kanthala Sanghavi, Deekonda Sanjana
Department of Pharmacology, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, Telangana.
*Corresponding Author
Published In:
Volume - 16,
Issue - 2,
Year - 2026
ABSTRACT:
Depression is a mental illness characterized by persistent feelings of sadness and despair. In this study, the antidepressant effects of two Ayurvedic formulations, Aswagandharista, Shankhpuspi syrup were invesigated and compared with standard drug, Fluoxetine in animal models of depression, specifically the Tail Suspension Test (TST) and Forced Swim Test (FST). Swiss Albino mice, weighing 20-25g, were divided into six groups (n=6 per group). Group I animals were treated with vehicle; Group II animals were treated with Standard drug Fluoxetine (10mg/kg); Group III animals were treated with Low Dose Shankhpuspi syrup 1.8ml/kg (LDSP); Group IV were treated with High Dose Shankhpuspi syrup 3.6ml/kg (HDSP); Group V were treated with Low Dose Aswagandharista 2.6ml/kg (LDAG); Group VI were tTreated with High Dose Aswagandharista 5.2 ml/kg (HDAG). All treatments were administered for eight consecutive days. The impact of the formulations on the immobilization time in TST and FST was evaluated. Data was analyzed using one-way ANOVA followed by Dunnett’s test, with p<0.01 considered statistically significant.
Cite this article:
Jorige Archana, Kanthala Sanghavi, Deekonda Sanjana. Evaluation of Anti-depressant Potential of Marketed Ayurvedic Formulations. Asian Journal of Research in Pharmaceutical Sciences.2026; 16(2):107-0. doi: 10.52711/2231-5659.2026.00017
Cite(Electronic):
Jorige Archana, Kanthala Sanghavi, Deekonda Sanjana. Evaluation of Anti-depressant Potential of Marketed Ayurvedic Formulations. Asian Journal of Research in Pharmaceutical Sciences.2026; 16(2):107-0. doi: 10.52711/2231-5659.2026.00017 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2026-16-2-2
REFERENCES:
1. Nemeroff CB. The neurobiology of depression. Scientific American. 1998 Jun 1; 278(6):42-9.
2. Willner P, Belzung C. Treatment-resistant depression: are animal models of depression fit for purpose?. Psychopharmacology. 2015 Oct; 232: 3473-95.
3. Jaseela KP, Anjan Kumar, Veeresh Babu. D, Narayana Swamy V.B. Studies on Anti-depressant and Anti-inflammatory Activities of Curcuma aromatica Rhizome in Experimental Animal Models. Asian J. Pharm. Res. 2016; 6(2): 79-86. doi: 10.5958/2231-5691.2016.00014.9
4. Swapna E, Mohan GK, Nagaveni P, Shanker K. Evaluation of antioxidant activity of marketed ayurvedic formulations-Balarishta. Research Journal of Pharmacognosy and Phytochemistry. 2015; 7(2): 107-10.
5. Paget GE, Barnes JM. Evaluation of drug activities. In: Lawrence DR, Bacharach AL, editors. Pharmacometrics. Vol. 1. New York: Academic Press; 1964. p. 161.
6. Yankelevitch-Yahav R, Franko M, Huly A, Doron R. The forced swim test as a model of depressive-like behavior. Journal of visualized experiments: JoVE. 2015 Mar 2(97): 52587.
7. Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology. 1985 Mar; 85: 367-70.
8. Salleh MR. The burden of mental illness: an emerging global disaster. Journal of Clinical and Health Sciences. 2018; 3(1):1-8.).
9. Nizamudeen.T, Ramanjaneyulu. J, Veeresh Babu. D, Narayana Swamy V.B. A Study on Antidepressant Activity of Medha gulika-a Polyherbal Formulation in Experimental Animal Models. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 2, Pg 115-121.
10. Gupta K, Ashok BK, Ravishankar B, Thakar AB. Anti-anxiety and anti-depressant activities of Sarasvata choorna in experimental animals. Ayu. 2011 Oct; 32(4): 590.
11. Shreevathsa M, Ravishankar B, Dwivedi R. Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation. Ayu. 2013 Jan; 34(1):113.
12. Sreejani Chavidi and Archana Jorige. A review on animal models of depression and their validity. JCRT. 2023 Jan; 11(1):661-65.
13. Schildkraut JJ. The catecholamine hypothesis of affective disorders: A review of supporting evidence. Am J Psychiatr. 1965; 122:509–22.
14. Cryan JF, Valentino RJ, Lucki I. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neuroscience & Biobehavioral Reviews. 2005 Jan 1; 29(4-5):547-69.
15. Komal D. Pol, Pradnya N. Jagtap, Vishakha Vikas Jagatap, Shweta S. Bobade, Vaishnavi P. More, Ankita M. Kadam, Pratibha Deshmukh, Ashwini Kunjir. Review Paper on Models for CNS Stimulant Drug Screening. Asian Journal of Pharmaceutical Research. 2024; 14(2):148-2.
16. Avani Shewale, N. S. Naikwade, P. L. Ladda. Antidepressant activity of Chrysanthemum morifolium Linn in mice. Asian J. Res. Pharm. Sci. 2019; 9(4):260-266. doi: 10.5958/2231-5659.2019.00040.7
17. Kim H, Choi HS, Han K, Sim W, Suh HJ, Ahn Y. Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway under unexpected chronic mild stress. Journal of Ethnopharmacology. 2025 Jan 31; 340:119224.
18. Mani V, Sajid S, Rabbani SI, Alqasir AS, Alharbi HA, Alshumaym A. Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice. Journal of Traditional and Complementary Medicine. 2021 Nov 1; 11(6):493-502.
19. Dhingra D, Sharma A. Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2006 May 1; 30(3):449-54.
20. Dhingra D, Valecha R. Screening for antidepressant-like activity of Convolvulus pluricaulis Choisy in mice. Pharmacol online. 2007; 1:262-78.
21. Malarkodi Velraj, V. Ravichandiran, S. Ramamoorthy, A. Vijayalakshmi, J Srikanth. Antidepressant-Like Effects of the Ethanolic Extract of Albizzia lebbeck (Linn) Leaves in Animal Models of Depression. Research J. Pharmacognosy and Phytochemistry 2010; 2(1): 30-33.
22. Ajay Kumar Meena, Anshul Sinha, S. C. Verma, M. D. Gupta, M. M. Padhi. HPTLC Profile of Important Indian Spices used in Ayurvedic Formulations. Research J. Pharmacognosy and Phytochemistry 2013; 5(4):188-193.