Author(s):
Moein S. Attar, Ram S. Sakhare, Vivek B. Panchbhai, Vijayendra Swamy S. M., Vaishnavi R. Khandade
Email(s):
moinattar@gmail.com
DOI:
10.52711/2231-5659.2026.00018 
Address:
Moein S. Attar1*, Ram S. Sakhare2, Vivek B. Panchbhai3, Vijayendra Swamy S. M.4, Vaishnavi R. Khandade5
1Research Scholar, Channabasweshwar Pharmacy College (Degree), Latur, Affiliated to SRTMU Nanded, Maharashtra, India.
2Head, Department of Pharmaceutical Quality Assurance, Channabasweshwar Pharmacy College (Degree), Latur, Maharashtra, India.
3Head, Department of Pharmaceutical Chemistry, Channabasweshwar Pharmacy College (Degree), Latur, Maharashtra, India.
4Principal, Channabasweshwar Pharmacy College (Degree), Latur, Maharashtra, India.
5Research Student, Channabasweshwar Pharmacy College (Degree), Latur, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 2,
Year - 2026
ABSTRACT:
An efficient and cost-effective RP-HPLC method was optimized for the concurrent quantification of fluconazole and terbinafine in combined tablet formulations. Separation was accomplished on a Discovery C18 column (150 × 4.6mm, 5µm) using a mobile phase comprising 0.01N sodium hydrogen phosphate buffer and acetonitrile (70:30 v/v), delivered at 1.2mL/min under isothermal conditions (30°C). UV detection at 246nm yielded distinct retention times of 2.16 min for fluconazole and 3.09 min for terbinafine. The method demonstrated high precision (%RSD < 0.5), excellent recovery (99.69% for fluconazole and 100.15% for terbinafine), and low detection limits (0.52µg/mL and 0.17µg/mL, respectively). Linearity was confirmed with correlation coefficients exceeding 0.999. The rapid analysis and reduced solvent consumption render this method highly suitable for routine quality control in pharmaceutical settings.
Cite this article:
Moein S. Attar, Ram S. Sakhare, Vivek B. Panchbhai, Vijayendra Swamy S. M., Vaishnavi R. Khandade. Validated Stability Indicating RP HPLC Method for the Dual Drug Analysis of Fluconazole and Terbinafine in Solid Oral Dosage Forms. Asian Journal of Research in Pharmaceutical Sciences.2026; 16(2):111-6. doi: 10.52711/2231-5659.2026.00018
Cite(Electronic):
Moein S. Attar, Ram S. Sakhare, Vivek B. Panchbhai, Vijayendra Swamy S. M., Vaishnavi R. Khandade. Validated Stability Indicating RP HPLC Method for the Dual Drug Analysis of Fluconazole and Terbinafine in Solid Oral Dosage Forms. Asian Journal of Research in Pharmaceutical Sciences.2026; 16(2):111-6. doi: 10.52711/2231-5659.2026.00018 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2026-16-2-3
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