Author(s):
Umair Akhtar, Anjali M. Wankhade, Yashashri P. Dhokane, Sufiyan Akhtar
Email(s):
umairakhtar1999@gmail.com
DOI:
10.52711/2231-5659.2023.00053 
Address:
Umair Akhtar*, Anjali M. Wankhade, Yashashri P. Dhokane, Sufiyan Akhtar
Department of Pharmacology, Vidyabharati College of Pharmacy, C.K. Naidu Road, Camp, Amravati - 444602 (Maharashtra), India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 4,
Year - 2023
ABSTRACT:
Post-traumatic stress disorder (PTSD) is a mental health condition caused by witnessing or experiencing a terrifying event The anxiety disorder known as post-traumatic stress disorder (PTSD) is very common and has been linked to a higher risk of hypertension and cardiovascular disease. Types of PTSD are Normal Stress Response, Acute Stress Disorder, Uncomplicated, Complex, Comorbid. There are many factors that can contribute to someone developing posttraumatic stress disorder. Flashbacks, nightmares, excruciating anxiety, and uncontrollable thoughts about the incident are all possible symptoms. The amygdala is a component of the neural circuitry involved in emotional learning, fear, and anxiety. is a diverse disorder that has an impact on a person's behaviour, physical health, and mood as well as biological, psychological, and environmental factors. Anxiety types- Panic Disorder or OCD. There may be a feeling of disconnection between your mind and body that makes you feel out of control. Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) are frequently used in the treatment of PTSD and anxiety disorders, sertraline (Zoloft), paroxetine (Paxil), and fluoxetine (Fludac) approval for the treatment of PTSD. Many PTSD patients may turn to alcohol, drugs, or even suicide during this time in an effort to cope with the agoraphobia, depression, and nightmares.
Cite this article:
Umair Akhtar, Anjali M. Wankhade, Yashashri P. Dhokane, Sufiyan Akhtar. Approaches towards Anxiety due to Post Traumatic Stress Disorder : A Review. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(4):313-7. doi: 10.52711/2231-5659.2023.00053
Cite(Electronic):
Umair Akhtar, Anjali M. Wankhade, Yashashri P. Dhokane, Sufiyan Akhtar. Approaches towards Anxiety due to Post Traumatic Stress Disorder : A Review. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(4):313-7. doi: 10.52711/2231-5659.2023.00053 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2023-13-4-8
REFERENCES:
1. Cahill SP, Pontoski K. Post-traumatic stress disorder and acute stress disorder I: their nature and assessment considerations. Psychiatry (Edgmont). 2005; 2(4): 14-25.
2. White J, Pearce J, Morrison S, Dunstan F, Bisson JI, Fone DL. Risk of post-traumatic stress disorder following traumatic events in a community sample. Epidemiology and Psychiatric Sciences. 2015; 24(3): 249-57.
3. Yehuda, Rachel. Post-Traumatic Stress Disorder. 2002; 346(2), 108–114.
4. Miao, XR. Chen, QB., Wei, K. et al. Posttraumatic stress disorder: from diagnosis to prevention. Military Med Res. 2018; 5: 32.
5. [Internet] Available at: https://clinicaltrials.gov/ct2/show/ NCT01627301
6. Fonkoue IT, Hu Y, Jones T, Vemulapalli M, Sprick JD, Rothbaum B, Park J. Eight weeks of device-guided slow breathing decreases sympathetic nervous reactivity to stress in posttraumatic stress disorder. Am J Physiol Regul Integr Comp Physiol. 2020; 319(4): R466-R475.
7. Marissa Moore, Types of PTSD, PsychCentral, May 23, 2021, [Internet] Available from: https://psychcentral.com/ptsd/types-of-ptsd#normal-stress-response.
8. [Internet] Available at: https://www.fox26houston.com/houstons-morning-show/5-types-of-post-traumatic-stress-disorder
9. [Internet] [cited 2022] Available from: https://bestdaypsych.com/ ptsd-examined-the-five-types-of-post-traumatic-stress-disorder/
10. Terence M. Keane, Amy D. Marshall, and Casey T. Taft, POST Traumatic stress disorder: Etiology, Epidemiology, and Treatment Outcome, Annu. Rev. Clin. Psychol. 2006; 2: 161–97.
11. Sukhmanjeet Kaur Mann, Posttraumatic Stress Disorder 2022, StatPearls, [Internet] Available from: https://www.statpearls.com/ ArticleLibrary/viewarticle/27568
12. Sumner JA, Hagan K, Grodstein F, Roberts AL, Harel B, and Koenen KC. Posttraumatic stress disorder symptoms and cognitive function in a large cohort of middle–aged women. Depress Anxiety. 2017; 00: 1–11.
13. Hendrickson RC, Raskind MA. Noradrenergic dysregulation in the pathophysiology of PTSD. Experimental Neurology. 2016; 284: 181-95.
14. Agorastos, Agorastos and Astrid C. E. Linthorst. Potential Pleiotropic Beneficial Effects of Adjuvant Melatonergic Treatment in Posttraumatic Stress Disorder. Journal of Pineal Research. 2016; 1– 24. Retrieved (http://doi.wiley.com/10.1111/jpi.12330).
15. Pitman RK, Rasmusson AM, Koenen KC, Shin LM, Orr SP, Gilbertson MW, Milad MR, Liberzon I. Biological studies of post-traumatic stress disorder. Nat Rev Neurosci. 2012; 13(11): 769-87.
16. Jonathan E. Sherin and Charles B. Nemeroff . Post-traumatic stress disorder: the neurobiological impact of psychological trauma, Dialogues in Clinical Neuroscience. 2011; 13:3, 263-278.
17. Sherin JE, Nemeroff CB. Post-traumatic stress disorder: the neurobiological impact of psychological trauma. Dialogues Clin Neurosci. 2011; 13(3): 263-78.
18. Chris Antonio, PTSD: National Center for PTSD, US Department of Veteranns Affairs September. 15, 2022
19. [Internet] Available at : https://www2.hse.ie/conditions/ptsd/
20. [Internet] [cited July 06, 2018] Available from: https://www.mayoclinic.org/diseases-conditions/post-traumatic-stress-disorder/symptoms-causes/syc-20355967
21. Verbitsky A, Dopfel D, Zhang N. Rodent models of post-traumatic stress disorder: behavioral assessment. Translational psychiatry. 2020; 10(1): 132.
22. Willner P. Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case. Prog Neuropsychopharmacol Biol Psychiatry. 1986; 10(6): 677-90.
23. Iñiguez SD, Aubry A, Riggs LM, Alipio JB, Zanca RM, Flores-Ramirez FJ, Hernandez MA, Nieto SJ, Musheyev D, Serrano PA. Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiol Stress. 2016; 5: 54-64.
24. Saidel Moreno-Martínez, Hiram Tendilla-Beltrán, Vicente Sandoval, Gonzalo Flores, José A.Terrón, Chronic restraint stress induces anxiety-like behavior and remodeling of dendritic spines in the central nucleus of the amygdala, Behavioural Brain Research. 2022; 416: 113523, ISSN 0166-4328.
25. Md. Amjad Hossen, A.S.M. Ali Reza, Md. Badrul Amin, Mst. Samima Nasrin, et al Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer-aided model, original article on Wiley, 12 May 2021.
26. Soodan, Shivani and Ashwani Arya. Understanding the Pathophysiology and Management of the Anxiety Disorders. (2015).
27. Dillon Browne, Ph.D., What to know about anxiety, a medically reviewed, By Adam Felman on January 11, 2020, [Internet] Available from: https://www.medicalnewstoday.com/articles/ 323454.
28. Oliver Grundmann et al reported Anti-anxiety effects of herbal drug Journal of Ethnopharmacology. 2007; 110: 406–411, available online at,www.sciencedirect.com.
29. Erwin Krediet, Tijmen Bostoen, Joost Breeksema, Annette van Schagen, Torsten Passie, Eric Vermetten, Reviewing the Potential of Psychedelics for the Treatment of PTSD, International Journal of Neuropsychopharmacology. 2020; 23(6): 385–400.
30. Prof. Gregory M. Asnis, Shari R. Kohn, Margaret Henderson, Nicole L. Brown. SSRIs versus Non-SSRIs in Post-traumatic Stress Disorder. 2004; 64(4): 383–404.
31. Miao, XR., Chen, QB., Wei, K. et al. Posttraumatic stress disorder: from diagnosis to prevention. Military Med Res. 2018; 5: 32.
32. Judith Cukor; Josh Spitalnick; JoAnn Difede; Albert Rizzo; Barbara O. Rothbaum (2009). Emerging Treatments for PTSD. 2009; 29(8): 0–726.
33. Lynn, Debra. Pharmacological treatment of combatinduced PTSD: a literature review. British Journal of Nursing. 2010; 19(5): 318–321.
34. Lahousen T, Kapfhammer HP. Anxiety disorders - clinical and neurobiological aspects. Psychiatr Danub. 2018; 30(4): 479-490.
35. Rickels K, Moeller HJ. Benzodiazepines in anxiety disorders: Reassessment of usefulness and safety. World J Biol Psychiatry. 2019; 20(7): 514-518.
36. Chand SP, Marwaha R. Anxiety. [Updated 2022 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/ NBK470361/.