Amiza, Abdul Rauf, Ayesha Mohy ud Din, Fatima Ahmad, Saira Sehar, Adeel Ahmad Khawaja, Shah Muhammad Haroon, Rehana Iqbal
firstname.lastname@example.org , email@example.com
Amiza1, Abdul Rauf1, Ayesha Mohy ud Din1, Fatima Ahmad2, Saira Sehar1, Adeel Ahmad Khawaja1, Shah Muhammad Haroon1, Rehana Iqbal1
1Department of Chemistry, School of Science, University of Management and Technology, CII, Johar Town, Lahore, 54770, Pakistan.
2Department of Chemistry, School of Science, Aligarh Muslim University, Aligarh, India.
Volume - 12,
Issue - 1,
Year - 2022
The recent advancements in field of genomics and synthetic biology has paved the way for determination and utilization of pharmaceutical properties of beneficial plants. Foeniculum vulgare is a member of Apiaceae family, commonly known as fennel. It is globally distributed aromatic medicinal herb. F. vulgare falls in the category of World’s most important medicinal herb because of its economic status and pharmaceutical industrial applications. It has been used as herbal treatment for a longer period of time as an effective medicine to cure different ailments such as liver pain, kidney disorders, swollen stomach, abdominal pain, and mouth ulcerand no documented severe side effects reported. Essential oil, flavonoids and phenolic compounds are major chemical constituents of F.vulgare. Volatile and non-volatile compounds of this plant are responsible for its biological activities. The Pharmacological experiments performed by in vitro and in vivo models, revealed that F. vulgare has strong therapeutic effects. This review is supposed to shed the light on anti-bacterial, antioxidant, antidiabetic, antifungal, antimicrobial, antianxiety, hepatoprotective, memory protective, acaricidal, anti-cancer, anti-inflammatory and anti-mutagenic activities.
Cite this article:
Amiza, Abdul Rauf, Ayesha Mohy ud Din, Fatima Ahmad, Saira Sehar, Adeel Ahmad Khawaja, Shah Muhammad Haroon, Rehana Iqbal. A Concise Review on Toxicity and Pharmacological Aspects of Foeniculum vulgare with Emphasis on Anti-Cancer Potential. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(1):75-2. doi: 10.52711/2231-5659.2022.00013
Amiza, Abdul Rauf, Ayesha Mohy ud Din, Fatima Ahmad, Saira Sehar, Adeel Ahmad Khawaja, Shah Muhammad Haroon, Rehana Iqbal. A Concise Review on Toxicity and Pharmacological Aspects of Foeniculum vulgare with Emphasis on Anti-Cancer Potential. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(1):75-2. doi: 10.52711/2231-5659.2022.00013 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2022-12-1-13
1. Okoye, T.C., et al., Safe African Medicinal Plants for Clinical Studies, in Toxicological Survey of African Medicinal Plants. 2014, Elsevier. p. 535-555.
2. Aziz, M.A., et al., Traditional uses of medicinal plants practiced by the indigenous communities at Mohmand Agency, FATA, Pakistan. Journal of Ethnobiology and Ethnomedicine, 2018. 14(1): p. 2.
3. Shinwari, Z.K., Medicinal Plants Research in Pakistan. J Med Plants Res, 2010. 4(3): p. 161-76.
4. Tang, S.Y. and B. Halliwell, Medicinal plants and antioxidants: what do we learn from cell culture and Caenorhabditis elegans studies? Biochemical and Biophysical Research Communications, 2010. 394(1): p. 1-5.
5. Meshram, P., B. Pandey, and T.J.H. Mankhand, Extraction of lithium from primary and secondary sources by pre-treatment, leaching and separation: A Comprehensive Review. 2014. 150: p. 192-208.
6. Fennel, A.S., A Common Spice with Unique Medicinal Properties. Ann Complement Altern Med. 2018; 1 (1). 1001.
7. Singh, S.P., A Comprehensive Review on Pharmacological Activity of Foeniculum vulgare.
8. Rather, M.A., et al., Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arabian Journal of Chemistry, 2016. 9: p. S1574-S1583.
9. Beyazen, A., E. Dessalegn, and W. Mamo, Phytochemical screening and biological activities of leaf of Foeniculum vulgare (Ensilal). World Journal of Agricultural Sciences, 2017. 13(1): p. 01-10.
10. Grieve, M., A Modern Herbal the Medicinal Culinary Cosmetic and Economic Properties Cultivation and Folk-Lore of Herbs, Grases Fungi, Shrubs & Trees with All Their Modern Uses. 1970.
11. Kooti, W., et al., Therapeutic and pharmacological potential of Foeniculum vulgare Mill: a review. Journal of HerbMed Pharmacology, 2015. 4(1): p. 1-9.
12. Badgujar, S.B., V.V. Patel, and A.H. Bandivdekar, Foeniculum vulgare Mill: a review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. BioMed Research International, 2014. 2014.
13. Koppula, S. and H. Kumar, Foeniculum vulgare Mill (Umbelliferae) attenuates stress and improves memory in wister rats. Tropical Journal of Pharmaceutical Research, 2013. 12(4): p. 553-558.
14. Al-Snafi, A.E.J.I.J.o.P., The chemical constituents and pharmacological effects of Foeniculum vulgare-A review. 2018. 8(5): p. 81-96.
15. Afify, A.E.-M.M.R., et al., Distribution of trans-anethole and estragole in fennel (Foeniculum vulgare Mill) of callus induced from different seedling parts and fruits. Notulae Scientia Biologicae, 2011. 3(1): p. 79-86.
16. Bernath, J., et al., Morphological and chemical evaluation of fennel (Foeniculum vulgare Mill.) populations of different origin. Journal of Essential Oil Research, 1996. 8(3): p. 247-253.
17. Rahimi, R. and M.R.S. Ardekani, Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy. Chinese Journal of Integrative Medicine, 2013. 19(1): p. 73-79.
18. Guarrera, P.M., G. Salerno, and G. Caneva, Folk phytotherapeutical plants from Maratea area (Basilicata, Italy). Journal of Ethnopharmacology, 2005. 99(3): p. 367-378.
19. Albert-Puleo, M., Fennel and anise as estrogenic agents. Journal of Ethnopharmacology, 1980. 2(4): p. 337-344.
20. Duško, B.L., L. Comiæ, and S. Sukdolak, Antibacterial activity of some plants from family Apiaceae in relation to selected phytopathogenic bacteria. Kragujevac J Sci, 2006. 28: p. 65-72.
21. Lo Cantore, P., et al., Antibacterial activity of Coriandrum sativum L. and Foeniculum vulgare Miller var. vulgare (Miller) essential oils. Journal of Agricultural and Food Chemistry, 2004. 52(26): p. 7862-7866.
22. Alhadidii, K.E.K. and A.N.H. Al-Waheeb, Effect of Foeniculum Vulgare fruit Volatile OILS Extract as an Antibacterial Against Respiratory Tract Infection Pathogens Activity.
23. Shahat, A.A., et al., Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars. Molecules, 2011. 16(2): p. 1366-1377.
24. Choi, E.-M. and J.-K. Hwang, Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia, 2004. 75(6): p. 557-565.
25. Tripathi, P., et al., Investigation of antimutagenic potential of Foeniculum vulgare essential oil on cyclophosphamide induced genotoxicity and oxidative stress in mice. Drug and Chemical Toxicology, 2013. 36(1): p. 35-41.
26. He, W. and B. Huang, A review of chemistry and bioactivities of a medicinal spice: Foeniculum vulgare. Journal of Medicinal Plants Research, 2011. 5(16): p. 3595-3600.
27. El-Soud, N., et al., Antidiabetic activities of Foeniculum vulgare Mill. essential oil in streptozotocin-induced diabetic rats. Macedonian Journal of Medical Sciences, 2011. 4(2): p. 139-146.
28. Sushruta, K., et al., Evaluation of the blood-glucose reducing effects of aqueous extracts of the selected umbelliferous fruits used in culinary practices. Tropical Journal of Pharmaceutical Research, 2006. 5(2): p. 613-617.
29. Özbek, H., et al., Hepatoprotective effect of Foeniculum vulgare essential oil. Fitoterapia, 2003. 74(3): p. 317-319.
30. Jamshidi, E., et al., Effects of different nutrition systems (organic and chemical) on quantitative and qualitative characteristics of Fennel (Foeniculum valgare Mill.) under water deficit stress. 2012.
31. Garga, C., et al., Chemical composition, therapeutic potential and perspectives of Foeniculum vulgare. Pharmacognosy Reviews, 2009. 3(6): p. 346.
32. Mohamad, R.H., et al., Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare). Journal of Medicinal Food, 2011. 14(9): p. 986-1001.
33. Salehi, B., et al., Insights on the anticancer potential of plant-food bioactives: A key Focus to Prostate Cancer. 2020. 66(4): p. 250-263.
34. Martin, E.J.M.i.C. and M. Biology, Defining Cancer: Causes and Treatments. 2019. 5(2).
35. Ke, W., et al., Foeniculum vulgare seed extract exerts anti-cancer effects on hepatocellular carcinoma. 2021. 12(4): p. 1482-1497.
36. Ke, W., et al., Foeniculum vulgare seed extract induces apoptosis in lung cancer cells partly through the down-regulation of Bcl-2. 2021. 135: p. 111213.
37. Mohamad, R.H., et al., Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare). 2011. 14(9): p. 986-1001.
38. Kammath, A.J., B. Nair, and L.R.J.J.o.F.B. Nath, Curry versus cancer: Potential of some selected culinary spices against cancer with in vitro, in vivo, and human trials evidences. 2021. 45(3): p. e13285.
39. Farid, A., et al., Synergetic role of senna and fennel extracts as antioxidant, anti-inflammatory and anti-mutagenic agents in irradiated human blood lymphocyte cultures. 2020. 13(1): p. 191-199.
40. AlSalhi, M.S., et al., Therapeutic Potential Assessment of Green Synthesized Zinc Oxide Nanoparticles Derived from Fennel Seeds Extract. 2020. 15: p. 8045.
41. Singh, G., et al., Chemical constituents, antifungal and antioxidative potential of Foeniculum vulgare volatile oil and its acetone extract. Food Control, 2006. 17(9): p. 745-752.
42. Joshi, H. and M. Parle, Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn. Journal of Medicinal Food, 2006. 9(3): p. 413-417.
43. Kwon, Y.S., et al., Antimicrobial constituents of Foeniculum vulgare. Archives of Pharmacal Research, 2002. 25(2): p. 154-157.
44. Al-Snafi, A.E.J.I.A.J.O.P.S., Medical importance of Juniperus communis-A Review. 2018. 5(3): p. 1779-1792.
45. Mesfin, M., et al., Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice. 2014. 14(1): p. 1-7.
46. Rather, M.A., et al., Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. 2016. 9: p. S1574-S1583.
47. Khan, M. and S. Musharaf, Foeniculum vulgare Mill. A medicinal herb. Medicinal Plant Research, 2014. 4.
48. Khan, M. and S.J.M.P.R. Musharaf, Foeniculum vulgare Mill. A Medicinal Herb. 2014. 4.