ABSTRACT:
Syndrome is defined by the development of a trichobezoar, or mass of swallowed hair, that grows from the stomach into the intestines. Psychiatric illnesses like trichotillomania and trichophagia, which cause compulsive hair pulling and eating, are commonly linked to this condition. Bezoars are gastrointestinal tract concretions that get bigger over time due to the constant buildup of fibers or non-absorbable meals. Trichobezoars—bezoars from swallowed hair from the head, toys, or brushes—make up the majority of bezoars in children. Even though Rapunzel Syndrome is uncommon, it presents serious diagnostic and treatment issues that frequently necessitate a multidisciplinary approach for successful therapy. Despite being uncommon, Rapunzel Syndrome needs to be recognized very away and treated with a multidisciplinary team. Improving patient outcomes requires early diagnosis, surgical excision of the trichobezoar, and thorough psychological treatment. The goal of this review is to give a thorough understanding of Rapunzel Syndrome, covering its pathophysiology, etiology, clinical presentation, diagnostic techniques, and treatment approaches. The essay focuses deeper into the disorder's psychosocial and psychiatric components as well, emphasizing how crucial it is to treat these elements in addition to surgical and medicinal treatments.
Cite this article:
KM Anshika Garg. Rapunzel Syndrome: When Hair becomes a Hazard – Insights into a Rare Gastrointestinal Disorder. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(4):366-0. doi: 10.52711/2231-5659.2025.00054
Cite(Electronic):
KM Anshika Garg. Rapunzel Syndrome: When Hair becomes a Hazard – Insights into a Rare Gastrointestinal Disorder. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(4):366-0. doi: 10.52711/2231-5659.2025.00054 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2025-15-4-4
REFERENCES:
1. Naik S, Gupta V, Naik S, Rangole A, Chaudhary AK, Jain P, Sharma AK. Rapunzel syndrome reviewed and redefined. Digestive Surgery. 2007 Jun 1; 24(3): 157-61.
2. Gonuguntla V, Joshi DD. Rapunzel syndrome: a comprehensive review of an unusual case of trichobezoar. Clinical Medicine & Research. 2009 Sep 1; 7(3): 99-102.
3. Fallon SC, Slater BJ, Larimer EL, Brandt ML, Lopez ME. The surgical management of Rapunzel syndrome: a case series and literature review. Journal of Pediatric Surgery. 2013 Apr 1; 48(4): 830-4.
4. Lalith S, Gopalakrishnan KL, Ilangovan G, Jayajothi A. Rapunzel syndrome. Journal of clinical and diagnostic research: JCDR. 2017 Sep; 11(9): TD01.
5. Frey AS, McKee M, King RA, Martin A. Hair apparent: Rapunzel syndrome. American Journal of Psychiatry. 2005 Feb 1; 162(2): 242-8.
6. Muskan Rathor, Anshika Garg. Gastroretentive drug delivery system: An Overview. Research Journal of Pharmaceutical Dosage Forms and Technology. 2024; 16(1): 91-7.
7. Altonbary AY, Bahgat MH. Rapunzel syndrome. Journal of Translational Internal Medicine. 2015 Jun 30; 3(2): 79-81.
8. Kim JS, Nam CW. A case of Rapunzel syndrome. Pediatric Gastroenterology, Hepatology & Nutrition. 2013 Jun 1; 16(2): 127-30.
9. Ullah W, Saleem K, Ahmad E, Anwer F. Rapunzel syndrome: a rare cause of hypoproteinaemia and review of literature. Case Reports. 2016 Sep 26; 2016: bcr2016216600.
10. Al-Wadan AH, Al-Absi M, Al-Saadi AS, Abdoulgafour M. Rapunzel syndrome. Saudi Medical Journal. 2006 Dec 1; 27(12): 1912.
11. Chogle A, Bonilla S, Browne M, Madonna MB, Parsons W, Donaldson J, Alonso E. Rapunzel syndrome: a rare cause of biliary obstruction. Journal of Pediatric Gastroenterology and Nutrition. 2010 Oct 1; 51(4): 522-3.
12. Phillips JD. Rapunzel syndrome in a pediatric patient: a case report. AANA Journal. 2012 Apr 1; 80(2): 115.
13. Obinwa O, Cooper D, Khan F, O’Riordan JM. Rapunzel syndrome is not just a mere surgical problem: A case report and review of current management. World Journal of Clinical Cases. 2017 Feb 2; 5(2): 50.
14. Parakh JS, McAvoy A, Corless DJ. Rapunzel syndrome resulting in gastric perforation. The Annals of The Royal College of Surgeons of England. 2016 Jan 1; 98(1): e6-7.
15. Iwama I, Nambu R, Hara T. A novel finding of Rapunzel syndrome. Clinical Journal of Gastroenterology. 2018 Feb; 11: 19-22.
16. Nettikadan A, Ravi MJ, Shivaprasad M. Recurrent Rapunzel syndrome–A rare tale of a hairy tail. International Journal of Surgery Case Reports. 2018 Jan 1; 45: 83-6.
17. Khanna K, Tandon S, Yadav DK, Khanna V. Rapunzel syndrome: a tail too long to tell! Case Reports. 2018 Apr 5; 2018: bcr-2018.
18. Mahendra G. Rapunzel Syndrome. Journal of Research: THE Bede Athenaeum. 2011; 2(2): 43-52.
19. Vila S, García C, Piscoya A, De Los Ríos R, Pinto JL, HuertaMercado J, Bussalleu A. Giant gastroduodenal trichobezoar: Rapunzel syndrome. Official Journal of the American College of Gastroenterology| ACG. 2009 Nov 1; 104(11): 2864-5.
20. Leite S, Reis C, Esteves M. Rapunzel Syndrome: a case report. IJCNMH. 2014; 1:5.
21. Wolfson PJ, Fabius RJ, Leibowitz AN. The Rapunzel syndrome: an unusual trichobezoar. American Journal of Gastroenterology (Springer Nature). 1987 Apr 1; 82(4).
22. Chin X, Ng JY. Acute presentation of Rapunzel syndrome and a review of bezoars. Cureus. 2021 Dec; 13(12).
23. Athanasiou A, Michalinos A, Moris D, Spartalis E, Dimitrokallis N, Kaminiotis V, Oikonomou D, Griniatsos J, Felekouras E. Rapunzel syndrome: a rare presentation with giant gastric ulcer. Case Reports in Medicine. 2014; 2014(1): 267319.
24. Schuler L, Hodel M, Stieger C. The Rapunzel syndrome: a hairy tale. Surgical Case Reports. 2023 Mar 28; 9(1):49.
25. Balik E, Ulman I, Taneli C, Demircan M. The Rapunzel syndrome: a case report and review of the literature. European Journal of Pediatric Surgery. 1993 Jun; 3(3): 171-3.
26. Wang Z, Cao F, Liu D, Fang Y, Li F. The diagnosis and treatment of Rapunzel syndrome. Acta Radiologica Open. 2016 Nov; 5(11): 2058460115627660.
27. Gupta R, Prabhakar G, Mathur P, Goyal RB, Sharma C, Ali MA. Rapunzel syndrome and its variants in pediatric patients: Our experience. Arch Int Surg. 2014 Sep 1; 4(4): 152-7.