Author(s):
P. Usha Lakshmi, K. Tejaswini, B. Hemalatha, K. Padmalatha
Email(s):
balahemalatha25@gmail.com
DOI:
10.52711/2231-5659.2023.00041 
Address:
P. Usha Lakshmi1, K. Tejaswini1, B. Hemalatha*1, K. Padmalatha2
1Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada.
2Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada.
*Corresponding Author
Published In:
Volume - 13,
Issue - 3,
Year - 2023
ABSTRACT:
Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. Microspheres have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, to simulate controlled drug release. Microspheres are characteristically free flowing solid powders, which consist of proteins or synthetic polymer, which are biodegradable in nature. Microspheres having particle size in range between 0.1 - 200µm, can be delivered by several routes like oral, parentral, nasal, ophthalmic, transdermal, colonal etc. Various recent advancement in case of microspheres like mucoadhesive, hollow, floating, microballons, magnetic have been contributed to overcome the various problems that are associated with the use of microspheres, which includes site specific targeting and improved release kinetics. In future by combining various new strategies, microspheres will find a central place in novel drug delivery, particularly in diseased cell sorting, genetic materials, safe, targeting and effective drug delivery.
Cite this article:
P. Usha Lakshmi, K. Tejaswini, B. Hemalatha, K. Padmalatha. Microspheres: A Comprehensive Review. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(3):235-0. doi: 10.52711/2231-5659.2023.00041
Cite(Electronic):
P. Usha Lakshmi, K. Tejaswini, B. Hemalatha, K. Padmalatha. Microspheres: A Comprehensive Review. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(3):235-0. doi: 10.52711/2231-5659.2023.00041 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2023-13-3-9
REFERENCES:
1. Chaudhari A, Jadhav K. R, Kadam VJ. An Overview: Microspheres as a Nasal Drug Delivery System. Int. J. of Pharmaceutical Sciences Review and Res. 2010; 5(1): 8 - 17.
2. Vyas SP, Khar RK. Targeted and Controlled drug delivery; 7th Edition; Vallabh Prakashan, New Delhi India, 420 - 445.
3. Sree Giri Prasad B., Gupta V. R. M., Devanna N., Jayasurya K., Microspheres as drug delivery system – A review. JGTPS. 2014; 5(3): 1961 - 72.
4. Ghulam M., Mahmood A., Naveed A., Fatima R.A., Comparative study of various microencapsulation techniques. Effect of polymer viscosity on microcapsule characteristics. Pak. J. Sci. 2009; 22 (3): 291 - 300.
5. Li S.P., Kowalski C.R., Feld K.M., Grim W.M., Recent Advances in Microencapsulation Technology and Equipment. Drug Dev Ind Pharm. 1988; 14: 353-376.
6. Alagusundaram. M, MadhuSudana Chetty. C, Umashankari. K, Attuluri Venkata Badarinath, Lavanya. C and Ramkanth. S. Microspheres as a novel drug delivery system - A Review. International Journal of Chem Tech Research. 2009; 1(3): 526 - 534.
7. Shanthi N.C, Gupta R, Mahato K.A. Traditional and Emerging Applications of Microspheres: A Review. International Journal of Pharm Tech Research. 2010; 2(1): 675 - 681.
8. Bansal H., Kaur S. P., Gupta A. K., Microsphere: Methods of preparation and applications; a comparative study. Int J Pharm Sci. Rev Res. 2011; 10(1): 69 - 78.
9. Rastogi V, Shukla SS, Singh R, Lal N and Yadav P: Microspheres: a promising drug carrier. J Drug Deliv Ther. 2016; 6: 18-26.
10. Ankush Pralhad Jadhav, Tejashree Radhakisan Kedar, Rushikesh Narayan Jagtap. Formulation and Evaluation of Microspheres: A Review. International Journal for Research Trends and Innovation. 2022; 7(6): 311 - 315.
11. Akbal Ahmad and Abadhesh Kumar Niranjan. Microspheres: A novel approach for delivery of antihyperlipidemic drugs. IJPSR. 2022; 13(6): 2294 - 2302.
12. Nisha Sharma, Neha Purwar and Prakash Chandra Gupta. Microspheres as drug carriers for controlled drug delivery: A review. IJPSR. 2015; 6(11): 4579 - 4587.
13. Imran Abdul Kayyum Tadwee, Sadhana Shahi, M. Thube, Ankit S. Review on Microspheres. International Journal of Pharmaceutical Research & Allied Sciences. 2011; 1(1): 24 - 33.
14. Mahale Manisha M, Saudagar R B. Microsphere: A Review. Journal of Drug Delivery and Therapeutics. 2019; 9 (3-s): 854 - 856.
15. Sunny Patel, Rajeshwar Pandit Kumhal, Pandey Avindra Dinesh, Chetankumar C Gorantli. A Review on Microspheres: Types, Methods of Preparation, Effects of Process Variables and Applications. American Journal of Pharm Tech Research. 2020; 10(4): 123 -140.
16. Vishal Yadav, Prasad Galande, Smita Borkar. A Review on Microspheres: Preparation, Characterization and Applications. Asian Journal of Pharmaceutical Research and Development. 2022; 10(6): 128 - 133.
17. Sarlesh rajput, Preeti agrawal, Ashish Pathak, Nikhil Shrivasatava, Satyendra Singh Baghel, Rajendra singh baghel. A review on microspheres: Methods of preparation and evaluation. World Journal of Pharmacy and Pharmaceutical Sciences. 2012; 1(1): 422 - 438.
18. Parmar H, Bakliwal V. Different method of evaluation of mucoadhesive microsphere. Int J Appl Biol Pharm Technol. 2010; 1(3): 1164 - 65.
19. Meghna KS, Krishna MP, Giridas S, Sreelakshmi C, Vijayakumar B. Microsphere as a drug delivery system - A review. Int J Novel Trends Pharm Sci. 2017; 7: 109 - 18.
20. Agusundaram M, Madhu SC. Microsphere as a novel drug delivery system - A review. Int J ChemTech Res. 2009; 1(3): 526 - 34.
21. Vikrant KN, Gudsoorkar VR, Hiremath SN, Dolas RT, Kashid VA. Microspheres-A novel drug delivery system: An overview. Int J Pharm Chem Sci 2012; 1(1): 113-28.
22. Sahil K, Akanksha M, Premjeet S, Bilandi A, Kapoor B. Microsphere: A review. Int J Res Pharm Chem. 2011; 1(4): 2231 - 781.