Author(s): Sakshi D. Dandgawal, Rahul Y. Pagar, Dhananjay M. Patil

Email(s): sakshidandgawal5001@gmail.com

DOI: 10.52711/2231-5659.2023.00035   

Address: Sakshi D. Dandgawal, Rahul Y. Pagar, Dhananjay M. Patil
Divine College of Pharmacy, Nampur Road, Satana, Nashik 423301.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2023


ABSTRACT:
Before inhibitors of the proton pump and antagonists of the H2 receptor, the mainstay of therapy was antacids for acid-peptic diseases. In this work different tests for characterization of different brands of antacid granules were carried out. This study set out to compare the quality of five antacid brands. Angle of repose, Bulk density, Tapped density, Carr's index, Hausner's ratio, Effervescent duration, Preliminary Antacid Test, Acid Neutralizing Capacity, Reheis Test, and Rosette Rice Test were used to compare the antacid granules. In the examination of several antacid granules available in the market, the values of bulk density, tapped density, angle of repose, carr's index, and hausner's ratio reveal that Brands A, B, and D have good flow property, Brand C has fair property, and Brand E has passable flow property. Brand A has a shorter effervescent time than other brands, while Brand D has a longer one. Because the antacid-acid (HCl) solution's pH for each brand is found to be greater than pH 3.5, all of the brands are considered to be antacids. The acid neutralizing capacity (ANC) test reveals that none of the antacid products meet the US FDA's requirement that they have an acid neutralizing capacity of at least 5 mEq. The Reheis test revealed that Brand B needed more time than other brands to neutralize, but Brand D needed less time. Brand A required less time than other brands to maintain the pH level between 3 and 5, while Brand D required more time, according to the Rosette rice test.


Cite this article:
Sakshi D. Dandgawal, Rahul Y. Pagar, Dhananjay M. Patil. Comparative Characterization of Marketed Antacid Granules. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(3):201-5. doi: 10.52711/2231-5659.2023.00035

Cite(Electronic):
Sakshi D. Dandgawal, Rahul Y. Pagar, Dhananjay M. Patil. Comparative Characterization of Marketed Antacid Granules. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(3):201-5. doi: 10.52711/2231-5659.2023.00035   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2023-13-3-3


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