Author(s): Prashant S. Wake, M. D. Kshirsagar

Email(s): Email ID Not Available

DOI: 10.5958/2231-5659.2017.00013.3   

Address: Prashant S. Wake1*, Dr. M. D. Kshirsagar2
1Research Scholar, P. Wadhwani College of Pharmacy, Yavatmal (M. S.)
2Professor, P. Wadhwani College of Pharmacy, Yavatmal (M. S.)
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2017


ABSTRACT:
Transdermal drug delivery system (TDDS) is the dosage forms which deliver a therapeutically effective amount of drug across a patient’s skin. The Solid lipid nanoparticles were successfully developed for rasagiline mesylate. SLN dispersions were prepared by melt emulsification and solidification at low temperature method. Physicochemical characterization including particle size, particle size distribution, Zeta potential, scanning electron microscopy, crystallinity study by DSC were carried out. In the Transdermal Drug Delivery System, Formulations F1-F9 was prepared by solvent casting method using 1.5%, 2.5% and 3.5% of HPMC K4M and 20%, 30% and 40% (w/w of dry polymer) of PEG 400. The formulation F5 was selected as the promising formulation on the basis of tensile strength, % elongation, and % drug content. Further, the patch was found to be free of skin irritation. From the results stability study it can be concluded that the patches can be stored at 40°C and 75% RH without any significant stability problems. The formulation satisfied all the pharmaceutical parameters of transdermal films and appears to be promising.


Cite this article:
Prashant S. Wake, M. D. Kshirsagar. Design and Characterization of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System. Asian J. Res. Pharm. Sci. 2017; 7(2): 87-91. doi: 10.5958/2231-5659.2017.00013.3


Recomonded Articles:

Author(s): Mohd. Yaqub Khan, Maryada Roy, Brijesh Kumar Saroj, Sudhakar Dubey, Vineet Kumar Sharma

DOI: 10.5958/2231-5659.2015.00019.3         Access: Open Access Read More

Author(s): Dibyajyoti Saha, Milan Hait, Mayukh Jana, Suprodip Mandal, Utpal Jana

DOI:         Access: Open Access Read More

Author(s): Namdeo Shinde, Nagesh Aloorkar, Ajit Kulkarni, Bhaskar Bangar, Suyog Sulake, Pratik Kumbhar

DOI:         Access: Open Access Read More

Author(s): Pankaj R. Dhapake, Chauriya C.B., Umredkar R.C.

DOI: 10.5958/2231-5659.2017.00001.7         Access: Open Access Read More

Author(s): Rajashri R. Kulkarni, Dipti G. Phadtare, Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00019.9         Access: Open Access Read More

Author(s): Saudagar R. B., Sarika V. Khandbahale

DOI: 10.5958/2231-5659.2017.00005.4         Access: Open Access Read More

Author(s): Muhammed Jameel VP, Ravikumar, Narayanaswamy VB

DOI: 10.5958/2231-5659.2016.00017.5         Access: Open Access Read More

Author(s): Manukondakeerthi, Lakshmiprasanna. J, Santhosh aruna M, Rama Rao N

DOI:         Access: Open Access Read More

Author(s): Pradeep Sahu, Neha Pinkalwar, Ravindra Dhar Dubey, Shweta Paroha, Shilpi Chatterjee, Tanushree Chatterjee

DOI:         Access: Open Access Read More

Author(s): Ismail Hussain, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

DOI: 10.5958/2231-5659.2016.00030.8         Access: Open Access Read More

Author(s): D.M. Shinkar, Bhushan S Bhamare, R.B. Saudagar

DOI: 10.5958/2231-5659.2016.00011.4         Access: Open Access Read More

Author(s): Darekar A. B. , Zope Janhavi S. , Saudagar R. B.

DOI: 10.5958/2231-5659.2016.00013.8         Access: Open Access Read More

Author(s): Pradnya M. Khandagale, Bhushan Bhairav, R. B. Saudagar

DOI: 10.5958/2231-5659.2016.00038.2         Access: Open Access Read More

Author(s): K.Vijaya Sri, Guda Santhoshini, D. Ravi Sankar, K.Niharika

DOI: 10.5958/2231-5659.2018.00005.X         Access: Open Access Read More

Author(s): AK Mohiuddin

DOI: 10.5958/2231-5659.2019.00004.3         Access: Closed Access Read More

Author(s): Ameena Samreen, Mohammed Riyaz, Amtul Asiya, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5659.2017.00007.8         Access: Open Access Read More

Author(s): S. S. Shuka, Bina Gidwani, R. Pandey, S. P. Rao, V. Singh, Amber Vyas

DOI:         Access: Open Access Read More

Author(s): Amol P. Suryawanshi, Dattatraya M. Shinkar, R.B. Saudagar.

DOI: 10.5958/0975-4377.2015.00013.0         Access: Open Access Read More

Author(s): Sushil D. Patil, Prajkta Varpe, Sayali Chaure, Siddharth B. Bhalerao, Sanjay Kshirsagar

DOI: 10.5958/2231-5659.2017.00034.0         Access: Open Access Read More

Author(s): Vrushali R. Kadam, M. P. Patil, Vrushali V. Pawar, Sanjay Kshirsagar

DOI: 10.5958/2231-5659.2017.00030.3         Access: Open Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231-5659 


Recent Articles




Tags