Author(s): Bhagyashri V. Aiwale, Bharatee P. Chaudhari, Atish B. Velhal, Vivekkumar K. Redasani

Email(s): bhagyashriaiwale1998@gmail.com

DOI: 10.52711/2231-5659.2022.00054   

Address: Bhagyashri V. Aiwale*, Bharatee P. Chaudhari, Atish B. Velhal, Vivekkumar K. Redasani
YSPM’s Yashoda Technical Campus, Faculty of Pharmacy, Wadhe, Satara, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2022


ABSTRACT:
The ‘in situ gel’ system has appeared as one of the most effective drug delivery systems. Its specific distinguishing feature of 'Sol to Gel' transition aids in the continuous and controlled release of medicines. These systems have a number of advantages, including simple production, convenience of use, enhanced adherence, and patient comfort by lowering drug delivery frequency due to their distinctive sol to gel transition characteristics. An in-situ gelling system is a formulation that is in solution form before penetrating the body but transforms to gel form under specified physiological conditions. This review mainly focused on introduction, Advantages and Disadvantages of in situ gel, mechanism, types of Polymers used, Evaluation of in situ gel and its applications.


Cite this article:
Bhagyashri V. Aiwale, Bharatee P. Chaudhari, Atish B. Velhal, Vivekkumar K. Redasani. A Review on in situ Gel of Gastro Retentive Drug Delivery System. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(4):314-0. doi: 10.52711/2231-5659.2022.00054

Cite(Electronic):
Bhagyashri V. Aiwale, Bharatee P. Chaudhari, Atish B. Velhal, Vivekkumar K. Redasani. A Review on in situ Gel of Gastro Retentive Drug Delivery System. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(4):314-0. doi: 10.52711/2231-5659.2022.00054   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2022-12-4-10


REFERENCE:
1.    Kapoor C, Mohammed G. A and Adinarayana S. Formulation and evaluation of oral sustained in situ gelling system of Roxatidine. Indonesian Journal Pharmacy. 2017; 179-184.
2.    Sindhoor S. M, Sneh P and Maxwell A. Formulation and evaluation of novel insitu gel of lafutidine for gastro retentive drug delivery. Asian journal of Pharmaceutics and Clinical Research. 2018; 88-94.
3.    Shah J, Shah Sand Upadhyay P. In situ gel: A novel approach of gastroretentive drug delivery. Asian Journal of Biomedical and Pharmaceutical Science 2012; 1-8.
4.    Thomas L. M. Formulation and evaluation of floating oral in-situ gel of metronidazole. International Journal Pharmacy. 2014; 6:265-9.
5.    Mohanty D, Simharaju N and Haque A. A review: a novel drug delivery system. International Journal Pharmacy. 2018; 175-181.
6.    Konatham M, Gorle M. T and Pathakala N. In situ gel Polymers: A Review. International Journal Applied Pharmaceutics. 2020; 86-90.
7.    Saudagar R. B, Khandbahale S. V. In situ nasal gel – A review. Asian Journal of Research Pharmaceutical Science. 2017; 7 (1).
8.    Choudhary S, Kumar P, Pandit V, Singh M. A. Mucoadhesive In situ nasal gel; a promising approach. Asian Journal of Research Pharmaceutical Science. 2021; 11 (1)
9.    Gurny R, Ibrahim H and Buri P. The development & use of in situ formed gel triggered by pH. In Biopharmaceutics of Ocular Drug Delivery. ed. Edman. 1993; 81-90.  
10.    Cohen S, Lobel E, Trevgoda A, Peled Y et al.A novel in situforming ophthalmic drug delivery system from alginates undergoing gelation in the eye. Journal of Controlled Release. 1997; 44: 201–208.  
11.    Wen-Di Ma, Hui Xu, Chao Wang, Shu-Fang Nie, Wei-San Pan et al. Pluronic F127-g-poly(acrylic acid) copolymers as in situ gelling vehicle for ophthalmic drug delivery system. International Journal of Pharmaceutics.  2008; 350: 247-256.
12.    Vodithala S, Khatry S, Shastri N. M, Sadanandam et al. Formulation and evaluation of ion activated ocular gels of ketorolac tromethamine. International Journal of Current Pharmaceutical Research. 2010; 2 (3).  
13.    Rajas N. J, Kavitha K, Gounder T, Mani T et al. In-Situ ophthalmic gels a developing trend.  International Journal Pharmaceutical Science and Research. 2011; 7: 8-14.
14.    Motto F, Gailloud P. In-vitro  assessment of new embolic liquids prepared from preformed polymers and water miscible solvents aneurysm treatment. Biomaterials. 2000; 21:803-811.
15.    Guo J, Skinner G, Harcum W, Barnum P et al. Pharmaceutical applications of naturally occurring water soluble polymers.  Pharmaceutical Scienceand Technology. 1998; 1:254-261.
16.    Burkoth A, Anseth K.A review of Photo crosslinked polyanhydrides: In situ forming degradable networks. Biomaterials. 2000; 21: 2395- 2404.
17.    Sawhney A, Pathak C, Hubbell J, Hill J, Desai N et al. Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled release carriers.US Patent 5410016. 1995.
18.    Podual K, Doyle F. J and Peppas N. A. Dynamic behavior of glucose oxidase-containing microparticles of poly (ethylene)- grafted cationic hydrogels in an environment of changing pH. Biomaterials. 2000; 21: 1439-50.
19.    Qiu Y, Park K. Environment-sensitive hydrogels for drug Delivery. Advanced Drug Delivery Reviews. 2001; 53: 321-39.
20.    Hoffman A. S. Afrassiabi A and Dong L. C. Thermally reversible hydrogels: II. Delivery and selective removal of substances from aqueous solutions. Journal of Controlled Release. 1986;4: 213-222.  
21.    Hong - Ru Lin, Sung K. C. Carbopol/ Pluronic phase change solutions for ophthalmic drug delivery. Journal of Controlled Release. 2000; 69: 379-388.
22.    Sali S. R, Gondkar S. B and Saudagar R. B.A Review on: Atrigel – The Magical Tool. Asian Journal of Research Pharmaceutical Science. 2018; 8(1).
23.    Miyazaki S, Kawasaki N. Comparison of in situ gelling formulations for the oral delivery of cimetidine. International Journal of Pharmacy. 2001;161-8.  
24.    Honarkar H, Barikani M, Applications of biopolymers I: chitosan. MonatshefteChemie Chemical. 2009; 140:1403-20.
25.    Indalkar Y. R, Pimpodkar N. V, Gaikwad P. S, Godase A. S.A comprehensive review on biodegradable polymers. Asian Journal of Research Pharmaceutical Science. 2016; 6(2).
26.    Reddy K, Krishna M. G, Satla S, Gaikwad S. Natural polysaccharide: versatile excipient for controlled drug delivery system. Asian Journal of Pharmaceutical Science. 2011; 6:275-86.
27.    Kalbhare S. B, Bhandwalkar M. J, Pawar R. K, Sagre A. R. Sodium Alginate cross-linked Polymeric Microbeads for oral Sustained drug delivery in Hypertension: Formulation and Evaluation. Asian Journal of Research Pharmaceutical Science 2020; 10 (3).
28.    Ismail F. A, Napaporn J, Hughes J. A, Brazean G. A. In situ gel formulation for gene delivery: release and myotoxicity studies. Pharmaceutical Development and Technology. 2000; 5:391-7.
29.    Venkataswamy M, Arul B, Keerthi S. A, Sagar K. A, Vanitha K et al. Preparation and evaluation of a mucoadhesive polymers from the extract of seeds of Annona squamosa linn. Asian Journal of Research Pharmaceutical Science. 2017; 7(3).
30.    Mohanty D, Bakshi V, Simharaju N, Haque M.A Review on insitu gel: A Novel Drug Delivery System. International Journal of Pharmaceutical Science. 2018; 50:175-811.
31.    Guad R. S, Surana S. Jand Gokhale G. S. Natural Excipient, Pragati Books Pvt. Ltd ;2006.
32.    Jatav V. S, Singh J. S, Sharma A. K, Singh S. K. Effect of Dimethyl Sulphoxides as Permeation Enhancer on Transdermal Patch of Nebivolol Hydrochloride.  Asian Journal of Research Pharmaceutical Science. 2013; 3 (1):08-11.
33.    Schiraldi C, La Gatta A, De Rosa M. Biotechnological production and application of hyaluronan. Biopolymers 2010; 20:387-412.
34.    Chenite A, Chaput C, Wang D, Combes C, Buschmann M. D, Hoemann C. D et al. Novel injectable solution of chitosan form biodegradable gels in situ. Biomaterials. 2000; 21:2155-61.
35.    Achouri D, Alhanout K and Piccerelle P. Recent advances in ocular drug delivery.Drug Devlopment and Industrial Pharmacy.2013; 39:1599-617.
36.    Shinkar D. M, Bhamare B. S and Saudagar R. B. Microsponges. Asian journal of research pharmaceutical science 2016; 6(2).
37.    Gambhire S. A, Bhalerao K. A, Singh S. In situ hydrogel: different approaches to ocular drug delivery. International Journalof Pharmaceutical Science. 2013; 5:27-36.
38.    Xu Y, Wang C, Tam KC, Li L. Salt-assisted and salt-suppressed sol-gel transition of methylcellulose in water. Langmuir. 2004; 20: 646-52.
39.    Jothi M, Harikumar S. L and Aggarwal G. In-situ ophthalmic gels for the treatment of eye diseases. International Journal of Pharmaceutical Sciences and Research. 2012; 3:1891-1904.
40.    Nanjawade B. K, Manvi F. V, Manjappa A. S. Review of in-situ forming hydrogels for sustained ophthalmic drug delivery. Journal of Controlled Release. 2007; 122:119-134.
41.    Almeida H, Amaral M. H, Lobao P, Lobo J. M. In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulation. Drug Discovery Today 2014; 19:400-13.
42.    Nagadev C. H, Rao M. D, Venkatesh P, Hepcykalarani D, Prema R et al. A Review on Transdermal Drug Delivery Systems.  Asian Journal of Research Pharmaceutical Science. 2020; 10 (2).
43.    Wu J, Wei W, Wang L. Y, Su ZG, Ma G et al. A thermosensitive hydrogel based on quaternized chitosan and poly (ethylene glycol) for nasal delivery system. Biomaterials 2007; 28: 2220-32.
44.    Bilensoy E, Rouf M. A, Imran V, Murat S, Hincal A. A. Mucoadhesive thermosensitive prolonged release vaginal gel for clotrimazole: β-cyclodextrin complex. AAPS Pharmaceutical Scientist. 2006; 7:38.
45.    Nayak A. M, Maji R and Das B. Gastro retentive drug delivery system: A review. Asian Journal of Pharmaceutics and Clinical Research. 2010;2-10.
46.    Samreen A, Mohammed R, Amtul A, Rasheed N, Mohammad A. S et al. An Overview of Various Subjects Included as Syllabus for B. Pharmacy Students by JNTUH for its Definitions, Significance, Objectives and Outcomes. Asian Journal of Research Pharmaceutical Science.2017; (7):1.

Recomonded Articles:

Author(s): Mohd. Yaqub Khan, Irfan Aziz, Imtiyaz Ahmad, Bipin Bihari, Hemant Kumar, Manju Panday

DOI:         Access: Open Access Read More

Author(s): Dibyajyoti Saha, Milan Hait, Mayukh Jana, Suprodip Mandal, Utpal Jana

DOI:         Access: Open Access Read More

Author(s): Saudagar R. B., Sarika V. Khandbahale

DOI: 10.5958/2231-5659.2017.00005.4         Access: Open Access Read More

Author(s): Ismail Hussain, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

DOI: 10.5958/2231-5659.2016.00030.8         Access: Open Access Read More

Author(s): Yogita R. Indalkar, Nayana V. Pimpodkar, Puja S. Gaikwad, Anita S. Godase

DOI: 10.5958/2231-5659.2016.00010.2         Access: Open Access Read More

Author(s): D.M. Shinkar, Bhushan S Bhamare, R.B. Saudagar

DOI: 10.5958/2231-5659.2016.00011.4         Access: Open Access Read More

Author(s): Sana Banu, Syeda Ayesha Farheen

DOI: 10.5958/2231-5659.2019.00015.8         Access: Open Access Read More

Author(s): Nikhil P. Mahalpure , Sheetal B. Gondkar , Ravindra B. Saudagar

DOI: 10.5958/2231-5659.2016.00014.X         Access: Open Access Read More

Author(s): Viral Patel

DOI:         Access: Open Access Read More

Author(s): Ameena Samreen, Mohammed Riyaz, Amtul Asiya, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5659.2017.00007.8         Access: Open Access Read More

Author(s): Pramod Patil, Someshwara Rao B, Suresh V Kulkarni, Basavaraj, Chetan Surpur , Anand Ammanage

DOI:         Access: Open Access Read More

Author(s): Rohan R. Vakhariya, Swati S. Talokar, V. R. Salunkhe, C. S. Magdum

DOI: 10.5958/2231-5659.2017.00008.X         Access: Open Access Read More

Author(s): Li Gun, Tian Han, Guo Rui, Du Ning

DOI: 10.5958/2231-5659.2017.00037.6         Access: Open Access Read More

Author(s): J. Kasthuri, A. Cholarajan, R. Vijayakumar, P. Muthukumaran

DOI:         Access: Open Access Read More

Author(s): Phalguna Yadagiri, Rama Rao Korapati

DOI:         Access: Open Access Read More

Author(s): G. Vasavi, P. Naga Haritha, B. Chandrashekar

DOI: 10.5958/2231-5659.2018.00021.8         Access: Open Access Read More

Author(s): Dasari Nirmala, Enjamuri Aslesha , M. Sudhakar

DOI:         Access: Open Access Read More

Author(s): Vishal Kumar, Attish Bhardwaj, Navdeep Singh, Kamya Goyal, Shammy Jindal

DOI: 10.52711/2231-5659.2021.00038         Access: Open Access Read More

Author(s): Smita Kolhe, Praveen Chaudhari, Dhananjay More

DOI:         Access: Open Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.52711/2231-5659 


Recent Articles




Tags