Author(s): Ahirwar Varsha, Khushwant S. Yadav, Shailendra Bindaiya

Email(s): varsha.ahirwar2010@gmail.com

DOI: 10.52711/2231-5659.2021-11-2-2   

Address: Ahirwar Varsha, Dr. Khushwant S. Yadav, Dr. Shailendra Bindaiya
Rajeev Gandhi College of Pharmacy, Bhopal (M.P).
Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (M.P.).
*Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2021


ABSTRACT:
Our studies on the performance of formulation development and evaluation of fast dissolving films of Oloptadine HCL its anti-allergic drug. Prepare mouth dissolving film of Oloptadine HCl by solvent casting method. To characterize the prepared mouth dissolving film of Oloptadine HCL in terms of— Thickness, percent elongation, tack test, swelling index, in-vitro disintegration time and dissolution test. Oloptadine OLO), 11-[{z}-3-(Dimethlamino) propylidene]-6-11-dihydrobenz [b, e] oxepin-2-acetic acid hydrochloride, is widely used as an antihistaminic. Oloptadine HCL is a relatively selective histamine H1-receptor antagonist that inhibits the release of histamine from mast cells. Oloptadine does not affect alpha-adrenergic dopamine, muscarinic type 1 and 2 or serotonin receptor. They are hydrophobic in nature and non-polar, sparingly soluble in water and freely soluble methanol, ethanol. Olopatadine HCl is a mouth dissolving film. We is trying to sort out the problem of allergic. They are rapidly onset of action, when placed upon the tongue that it is disperse rapidly swallowing within 3-5 seconds without need of water or chewing.


Cite this article:
Ahirwar Varsha, Khushwant S. Yadav, Shailendra Bindaiya. Formulation Development and Evaluation of Fast Dissolving Films of Oloptadine HCl. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(2):103-8. doi: 10.52711/2231-5659.2021-11-2-2

Cite(Electronic):
Ahirwar Varsha, Khushwant S. Yadav, Shailendra Bindaiya. Formulation Development and Evaluation of Fast Dissolving Films of Oloptadine HCl. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(2):103-8. doi: 10.52711/2231-5659.2021-11-2-2   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2021-11-2-2


REFERENCES:
1.    Puttipipatkhachorn S etal (2001) conducted studies on four different grades of chitosan   to prepare films. Salicylic acid and theophylline were incorporated into cast chitosan Films as model acidic and basic drugs.
2.    Hirokazu O etal (2001) examined the penetration rate of Lidocaine (LC) through excised oral mucosa from hamster cheek pouch and the in vitro release rate of LC from film dosage forms with hydroxypropylcellulose (HPC) as a film base.
3.    Francesco C etal (20l0), developed a fast-dissolving film made of low dextrose Equivalent   maltodextrins (MDX) containing nicotine hydrogen tartrate salt.
4.    Cillurzo F et al. (2008) prepared fast dissolving film of pioxicam using maltodextrin with low dextrose equivalent as film forming using casting and solvent evaporation method. Fast dissolving films of piroxicam showed high loading capacity of dose with dissolution rate.
5.    Kulkarni et al (2009) take the fast dissolving films of rofecoxib by solvent casting method by use of HPMC as polymer. They concluded that mouth dissolving films containg rofecoxib 4%w/v of PVA film exhibited revive tensile strength, folding endurance and percentage elongation.

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