Pharmacognostic Study, Phytochemical Screening and Neuroprotective Activity of Methanolic extract of Gynandropsis gynandra against Transient Global Ischemia induced brain damage in rats

D. Santhosha

doi:10.5958/2231-5659.2019.00024.9

Asian Journal of Research in Pharmaceutical Sciences

ISSN

2231-5659 (Online)
2231-5640 (Print)

Submit Article

Pharmacognostic Study, Phytochemical Screening and Neuroprotective Activity of Methanolic extract of Gynandropsis gynandra against Transient Global Ischemia induced brain damage in rats

Author(s): D. Santhosha

Email(s): santhosha.d@viper.ac.in

DOI: 10.5958/2231-5659.2019.00024.9

Address: D. Santhosha
Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak. 502 313
*Corresponding Author

Published In: Volume - 9, Issue - 3, Year - 2019

View HTML

View PDF

ABSTRACT:
Gynandropsis gynandra is found to contain flavonoids which are proven to be potent neuroprotective agents which could cross blood brain barrier easily and treat neurotoxicity. Neurons get damaged easily because of our current lifestyle which includes usage of gadgets, smartphones etc causing memory loss, degraded cognitive thinking and other disorders like stroke. The best way to treat or prevent this is intake of flavonoids which have protective effect. The aim of the work was to assess protective effect of methanolic extract of whole herb of Gynandropsis gynandra against cerebral ischemia induced brain damage in albino wister rats. Pharmacognostic studies and phytochemical screening was carried out using standard methods. Cerebral ischemia was induced by occluding carotid artery using nylon thread followed by reperfusion. Animals were sacrificed and immediately brains were isolated and analysed for various biochemical parameter estimation, brain infarct area and histopathological studies. Biochemical estimations were measured and results were expressed in terms of Mean ± SEM by using ANNOVA software. Pharmacognostic study gave relevant information about ash values and Extractive values. Methonolic extract of Gynandropsis gynandra have proven to have protective effect. Of all the three doses, 300mg/kg dose of the drug have shown maximum protective effect when compared to other two doses.

Keywords:

Cite this article:
D. Santhosha. Pharmacognostic Study, Phytochemical Screening and Neuroprotective Activity of Methanolic extract of Gynandropsis gynandra against Transient Global Ischemia induced brain damage in rats. Asian J. Res. Pharm. Sci. 2019; 9(3):156-162. doi: 10.5958/2231-5659.2019.00024.9

Cite(Electronic):
D. Santhosha. Pharmacognostic Study, Phytochemical Screening and Neuroprotective Activity of Methanolic extract of Gynandropsis gynandra against Transient Global Ischemia induced brain damage in rats. Asian J. Res. Pharm. Sci. 2019; 9(3):156-162. doi: 10.5958/2231-5659.2019.00024.9 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2019-9-3-2

Recomonded Articles:

Ways to improve Life Expectancy in Sickle Cell Anaemia Patients using Herbs

Author(s): Beatrice Y. Danladi, P. Geetha

DOI: 10.5958/2231-5659.2017.00031.5 Access: Open Access Read More

Phyto-Pharmacological Profile of Wrightia tinctoria

Author(s): Niraj Kale, Sanket Rathod, Snehal More, Namdeo Shinde

DOI: 10.52711/2231-5659.2021.00047 Access: Open Access Read More

Assessment of wound healing activity of roots of Bauhinia variegata Linn. by excision and incision model in Albino Rats

Author(s): Rajesh Kumar Sharma, Rajni G.P., Deepak Nathiya, Ashish Kumar Sharma

DOI: 10.5958/2231-5659.2015.00023.5 Access: Open Access Read More

Pharmacognostical and Antimicrobial investigation of Jatropha curcas, Linn., Leaf.

Author(s): K. P. Jaiganesh, B. Sreedharren, G. Arunachalam, R. Nirmala, R. Nepolean

DOI: Access: Open Access Read More

A Review on Pharmacognostical and Pharmacological Activity of Ougeinia oojeinensis

Author(s): Swati S. Shete, Ravindra Jadhav, Sunayana Vikhe

DOI: 10.52711/2231-5659.2022.00004 Access: Open Access Read More

Pharmacognostic Study, Phytochemical Screening and Neuroprotective Activity of Methanolic extract of Gynandropsis gynandra against Transient Global Ischemia induced brain damage in rats

Author(s): D. Santhosha

DOI: 10.5958/2231-5659.2019.00024.9 Access: Open Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available
DOI: 10.52711/2231-5659