Author(s):
Manthan R. Rode, Swati U. Kolhe, Omkar A. Devade, Swapnil S. Lad, Chetashri N. Patil, Rohit D. Nalawade, Asawari P Mansabdar
Email(s):
manthan9028@gmail.com
DOI:
10.52711/2231-5659.2024.00048
Address:
Manthan R. Rode1*, Swati U. Kolhe2, Omkar A. Devade2, Swapnil S. Lad1, Chetashri N. Patil1, Rohit D. Nalawade1, Asawari P Mansabdar1
1M-Pharm, Department of Pharmacology, AISSMS College of Pharmacy, Pune - 411001, Maharashtra, India.
2Faculty, Department of Pharmacology, AISSMS College of Pharmacy, Pune - 411001, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 3,
Year - 2024
ABSTRACT:
This review highlights the significance of licorice (Glycyrrhiza glabra) as a traditional medicinal plant with diverse therapeutic benefits. In India, where traditional remedies are widely preferred over allopathic medicines, thanks to its natural nature and fewer side effects, licorice has a notable position. Being one of the four "Medhya Rasayana" in Ayurveda, G. glabra has been used for memory enhancement, cognition, and nerve function improvements for over 4,000 years. Liquorice cultivation is widespread in several countries, and its chemical constituents include flavonoids, glycosides, triterpenoid aglycone, glycyrrhizin, and Glabridin. The plant has demonstrated multiple pharmacological activities such as, anti-inflammatory, antioxidant, memory enhancement, antistress, hepatoprotective, immunomodulation, antihyperglycemic, and anticancer effects. moreover, licorice shows antimicrobial, antinociceptive, dermatological, and neuroprotective properties. These diverse therapeutic effects have led to its potential use in various health-related concerns. To completely comprehend its modes of action, additional research is needed, define optimal dosages, and ensure long-term safety and efficacy. In conclusion, licorice stands as a significant herbal medicine with a rich history of use and remarkable potential for enhancing human health. Its multiple biological activities make it a valuable candidate for complementary and alternative medicine. Standardization of licorice extracts and rigorous quality control are essential for consistent therapeutic applications. As scientific research expands, licorice-based products are anticipated to play an increasingly vital role in holistic healthcare.
Cite this article:
Manthan R. Rode, Swati U. Kolhe, Omkar A. Devade, Swapnil S. Lad, Chetashri N. Patil, Rohit D. Nalawade, Asawari P Mansabdar. Herbal Healer: A Comprehensive Review of the Overall Plant Profile and Medicinal Properties of Glycyrrhiza glabra. Asian Journal of Research in Pharmaceutical Sciences. 2024; 14(3):299-3. doi: 10.52711/2231-5659.2024.00048
Cite(Electronic):
Manthan R. Rode, Swati U. Kolhe, Omkar A. Devade, Swapnil S. Lad, Chetashri N. Patil, Rohit D. Nalawade, Asawari P Mansabdar. Herbal Healer: A Comprehensive Review of the Overall Plant Profile and Medicinal Properties of Glycyrrhiza glabra. Asian Journal of Research in Pharmaceutical Sciences. 2024; 14(3):299-3. doi: 10.52711/2231-5659.2024.00048 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2024-14-3-17
REFERENCES:
1. Sofowora A, Ogunbodede E, Onayade A. The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional, Complementary and Alternative Medicines. 2013 Aug 14; 10(5): 210-29.
2. Seth SD, Sharma B. Medicinal plants in India. Indian Journal of Medical Research. 2004 Jul 1; 120(1) :9.
3. Antesh K Jha, Pankaj Verma, Mahesh Prasad, Nikhil K Sachan, Kumar Gautam. Alternative Medicine: An Introduction and Market Potential. Research J. Pharmacognosy and Phytochemistry. 2009; 1(3): 146-152.
4. Mukherjee PK, Wahile A. Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol. 2006 Jan 3; 103(1): 25-35. DOI: 10.1016/j.jep.2005.09.024.
5. Niraj S, Varsha S. Role of Medhya Rasayanas (Nootropic Drugs) in Developmental Disabilities of Children. Mental retardation. 2019; 25: 30.
6. Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira MB. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy Research. 2018 Dec; 32(12): 2323-39.
7. Anilkumar D, Joshi H, Nishteswar K. Review of Glycyrrhiza glabra (Yastimadhu)-a broad spectrum herbal drug. Pharma Science Monitor. 2012 Dec 1; 3(4).
8. Sharma D, Namdeo P, Singh P. Phytochemistry & pharmacological studies of glycyrrhiza glabra: A medicinal plant review. Int. J. Pharm. Sci. Rev. Res. 2021; 67(1): 187-94.
9. Al-Snafi AE. Glycyrrhiza glabra: A phytochemical and pharmacological review. IOSR Journal of Pharmacy. 2018; 8(6): 1-7.
10. Hasan MK, Ara I, Mondal MS, Kabir Y. Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra. Heliyon. 2021 Jun 1; 7(6).
11. Anwar F. Quantitative analysis of total phenolic, flavonoid contents and HPTLC fingerprinting for standardization of Glycyrrhiza glabra Linn. Roots. Arch Med. 2015; 1: 1-9.
12. Khaitov B, Karimov A, Khaitbaeva J, Sindarov O, Karimov A, Li Y. Perspectives of Licorice Production in Harsh Environments of the Aral Sea Regions. International Journal of Environmental Research and Public Health. 2022 Sep 18; 19(18): 11770.
13. Alsaadi DH, Raju A, Kusakari K, Karahan F, Sekeroglu N, Watanabe T. Phytochemical analysis and habitat suitability mapping of Glycyrrhiza glabra L. collected in the Hatay region of Turkey. Molecules. 2020 Nov 25; 25(23): 5529.
14. Kaur R, Kaur H, Dhindsa AS. Glycyrrhiza glabra: a phytopharmacological review. International Journal of Pharmaceutical Sciences and Research. 2013 Jul 1; 4(7): 2470.
15. El-Saber Batiha G, Magdy Beshbishy A, El-Mleeh A, M. Abdel-Daim M, Prasad Devkota H. Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L.(Fabaceae). Biomolecules. 2020 Feb 25; 10(3): 352.
16. Shah SL, Wahid F, Khan N, Farooq U, Shah AJ, Tareen S, Ahmad F, Khan T. Inhibitory effects of Glycyrrhiza glabra and its major constituent glycyrrhizin on inflammation-associated corneal neovascularization. Evidence-Based Complementary and Alternative Medicine. 2018 Apr 23; 2018.
17. Swati Tomar, Mohd Asif. Pharmacognostical Identification of Glycyrrhiza glabra L. Root. Res. J. Pharmacognosy and Phytochem. 2020; 12(2):87-93.
18. Nanda P, Singh JK, Dayal SM. Review of Yashtimadhu on Mental Health WSR to Medhya Rasayana.
19. Dastagir G, Rizvi MA. Glycyrrhiza glabra L.(Liquorice). Pakistan Journal of Pharmaceutical Sciences. 2016 Sep 1;29(5).
20. Kuang Y, Li B, Fan J, Qiao X, Ye M. Antitussive and expectorant activities of licorice and its major compounds. Bioorganic & Medicinal Chemistry. 2018 Jan 1;26(1):278-84.
21. Jahan Y, Siddiqui HH. Study of antitussive potential of Glycyrrhiza glabra and Adhatodavasica using a cough model induced by sulphur dioxide gas in mice. International Journal of Pharmaceutical Sciences and Research. 2012 Jun 1;3(6):1668.
22. Nirmala P, Selvaraj T. Anti-inflammatory and anti-bacterial activities of Glycyrrhiza glabra L. Journal of Agricultural Technology. 2011; 7(3): 815-23.
23. Zhou JX, Wink M. Evidence for anti-inflammatory activity of isoliquiritigenin, 18β glycyrrhetinic acid, ursolic acid, and the traditional Chinese medicine plants Glycyrrhiza glabra and eriobotrya japonica, at the molecular level. Medicines. 2019 May 10; 6(2): 55.
24. Frattaruolo L, Carullo G, Brindisi M, Mazzotta S, Bellissimo L, Rago V, Curcio R, Dolce V, Aiello F, Cappello AR. Antioxidant and anti-inflammatory activities of flavanones from Glycyrrhiza glabra L.(licorice) leaf phytocomplexes: Identification of licoflavanone as a modulator of NF-kB/MAPK pathway. Antioxidants. 2019 Jun 20;8(6):186.
25. Lateef M, Iqbal L, Fatima N, Siddiqui K, Afza N, Zia-ul-Haq M, Ahmad M. Evaluation of antioxidant and urease inhibition activities of roots of Glycyrrhiza glabra. Pak J Pharm Sci. 2012 Jan 1; 25(1): 99-102.
26. Sultana S, Haque A, Hamid K, Urmi KF, Roy S. Antimicrobial, cytotoxic and antioxidant activity of methanolic extract of Glycyrrhiza glabra. Agric Biol JN Am. 2010; 1(5): 957-60.
27. Zhou JX, Braun MS, Wetterauer P, Wetterauer B, Wink M. Antioxidant, cytotoxic, and antimicrobial activities of Glycyrrhiza glabra L., Paeonia lactiflora Pall., and Eriobotrya japonica (Thunb.) Lindl. extracts. Medicines. 2019 Mar 30; 6(2): 43.
28. Siracusa L, Saija A, Cristani M, Cimino F, D'Arrigo M, Trombetta D, Rao F, Ruberto G. Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves—Chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity. Fitoterapia. 2011 Jun 1; 82(4): 546-56.
29. Chakravarthi KK, Avadhani R, Narayan RS. Effect of Glycyrrhiza glabra root extract on learning and memory in wistar albino rats. Drug Invention Today. 2012 Aug 5; 4(7): 387-90.
30. Dhingra D, Parle M, Kulkarni SK. Memory enhancing activity of Glycyrrhiza glabra in mice. Journal of Ethnopharmacology. 2004 Apr 1; 91(2-3): 361-5.
31. Chakravarthi KK, Avadhani R. Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models: An experimental study. Journal of Natural Science, Biology, and Medicine. 2013 Jul; 4(2): 420.
32. Ko YH, Kwon SH, Lee SY, Jang CG. Liquiritigenin ameliorates memory and cognitive impairment through cholinergic and BDNF pathways in the mouse hippocampus. Archives of Pharmacal Research. 2017 Oct; 40: 1209-17.
33. Parle M, Dhingra D, Kulkarni SK. Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models. Journal of Medicinal Food. 2004 Dec 1;7(4):462-6.
34. Cui YM, Ao MZ, Li W, Yu LJ. Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice. Planta Medica. 2008 Mar;74(04):377-80.
35. Hasanein P. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta Physiologica Hungarica. 2011 Jun 1; 98(2): 221-30.
36. Kalaiarasi P, Pugalendi KV. Antihyperglycemic effect of 18β-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. European Journal of Pharmacology. 2009 Mar 15; 606(1-3): 269-73.
37. Mustafa SB, Akram M, Muhammad Asif H, Qayyum I, Hashmi AM, Munir N, Khan FS, Riaz M, Ahmad S. Antihyperglycemic activity of hydroalcoholic extracts of selective medicinal plants Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and their polyherbal preparation in alloxan-induced diabetic mice. Dose-Response. 2019 May 27; 17(2):1559325819852503.
38. Takii H, Kometani T, Nishimura T, Nakae T, Okada S, Fushiki T. Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice. Biological and Pharmaceutical Bulletin. 2001; 24(5): 484-7.
39. Kalaigandhi VE, Poovendran PO. Antimicrobial activity of Glycyrrhiza glabra against peptic ulcer produced Helicobacter pylori. Int J Curr Pharm Res. 2011; 3(4): 93-5.
40. Kaur D, Rana AC, Sharma N, Kumar S. Herbal drugs with anti ulcer activity. Journal of Applied Pharmaceutical Science. 2012 Mar 30(Issue): 160-5.
41. Nem Kumar Jain, Rituparna Roy, Hero Khan Pathan, Aditi Sharma, Shakhi Ghosh, Santosh Kumar. Formulation and Evaluation of Polyherbal Aqueous Gel from Psidium guajava, Piper betel and Glycerrhiza glabra Extract for Mouth Ulcer Treatment. Res. J. Pharmacognosy and Phytochem. 2020; 12(3): 145-148.
42. Lee CK, Park KK, Lim SS, Park JH, Chung WY. Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer. Biological and Pharmaceutical Bulletin. 2007 Nov 1; 30(11): 2191-5.
43. Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra root. Food and Chemical Toxicology. 2007 Dec 1; 45(12): 2470-8.
44. Rutuja Sawant, Aloka Baghkar, Sanjukta Jagtap, Lina Harad, Anagha Chavan, Nilofar A. Khan, Rupali P. Yevale, Mohan K. Kale. A Review on - Herbs in Anticancer. Asian J. Res. Pharm. Sci. 2018; 8(4): 179-184.
45. Bhandage A, Shevkar K, Undale V. Evaluation of antinociceptive activity of roots of Glycyrrhiza glabra Linn. Journal of Pharmacy Research. 2009 May; 2(5): 803-7.
46. Parlar A, ParlarKöprülü RE, Arslan SO, Çam SA, Pesen Özdoğan F, Yumrutaş Ö, Üçkardeş F, Ríos M, Martinez JL. Extract of Glycyrrhiza glabra root attenuates nociception in experimental pain models: The role of BKCa channels. Boletin Latinoamericano y Del Caribe de Plantas Medicinales y Aromaticas. 2022.
47. Sakr SA, Shalaby SY. Carbendazim-induced testicular damage and oxidative stress in albino rats: ameliorative effect of licorice aqueous extract. Toxicology and Industrial Health. 2014 Apr; 30(3): 259-67.
48. Malekinejad H, Mirzakhani N, Razi M, Cheraghi H, Alizadeh A, Dardmeh F. Protective effects of melatonin and Glycyrrhiza glabra extract on ochratoxin A—induced damages on testes in mature rats. Human & Experimental Toxicology. 2011 Feb; 30(2): 110-23.
49. Kim BJ, Kim JH, Kim HP, Heo MY. Biological screening of 100 plant extracts for cosmetic use (II): anti‐oxidative activity and free radical scavenging activity. International Journal of Cosmetic Science. 1997 Dec; 19(6): 299-307.
50. Lee J, Jung E, Park J, Jung K, Park E, Kim J, Hong S, Park J, Park S, Lee S, Park D. Glycyrrhizin induces melanogenesis by elevating a cAMP level in b16 melanoma cells. Journal of Investigative Dermatology. 2005 Feb 1; 124(2): 405-11.
51. Swati Siddheshwar Londhe, Mangesh Gautam Bhosale, Amol Arun Joshi. Formulation and Evaluation of Skin Whitening- Lightening Herbal Facewash. Asian J. Pharm. Tech. 2020; 10(4):245-249.
52. Zangeneh MM, Zangeneh A, Tahvilian R, Moradi R. Evaluation of the nephroprotective effect of Glycyrrhiza glabra L aqueous extract on CCl 4-induced nephrotoxicity in mice. Comparative Clinical Pathology. 2018 Sep; 27: 1119-26.
53. Basist P, Zahiruddin S, Khan MU, Gautam G, Jan B, Khan MA, Parveen R, Ahmad S. Metabolite profiling and nephroprotective potential of Glycyrrhiza glabra L. roots against cisplatin-induced nephrotoxicity in vitro and in vivo. Iranian Journal of Basic Medical Sciences. 2022 Nov; 25(11): 1286.
54. Suman. Herbs: An alternative approach in Nephroprotection. Research J. Pharmacognosy and Phytochemistry. 2013; 5(1): 15-2