Author(s):
Snehal Shrivastav, Rasika Rangari, Tushar Akhare, Yogita Charde, Govind Lohiya
Email(s):
Snehalshrivastav22@gmail.com
DOI:
10.52711/2231-5659.2025.00028 
Address:
Snehal Shrivastav1*, Rasika Rangari1, Tushar Akhare1, Yogita Charde1, Govind Lohiya2
1Shree Sainath College of Pharmacy, Nagpur.
2Gurunanak College of Pharmacy, Nagpur.
*Corresponding Author
Published In:
Volume - 15,
Issue - 2,
Year - 2025
ABSTRACT:
Curcumin, derived from turmeric is a natural polyphenolic compound, due to its diverse pharmacological properties has received a great deal of attention in recent years. However, its poor bioavailability and stability have posed challenges for its clinical applications. Researchers have focused on synthesizing curcumin derivatives with improved properties to overcome these limitations. This review article provides an overview of various curcumin derivatives and their potential therapeutic applications. Du? to th? compound's limit?d bioavailability from minimal absorption, rapid metabolisms, and systemic elimination, nov?l delivery t?chniqu?s ar? n??d?d. It has been shown that curcumin's stability and bioavailability can be improved by ?ncapsulating it in liposom?s, nanoparticl?s, and cyclod?xtrins. We discuss the structural modifications, synthesis methods, and the impact of these modifications on the pharmacokinetic and pharmacological properties of curcumin derivatives. Curcumin compounds with ?nhanc?d solubility, targ?t sp?cificity, and sustain?d r?l?as? prop?rti?s are a brilliant solution to ov?rcom? th?s? issu?s. Furthermore, we highlight the promising therapeutic applications of these derivatives, including anti-inflammatory, anticancer, antioxidant, anti-microbial, and neuroprotective activities. Additionally, we address the challenges and future perspectives in developing curcumin derivatives for enhanced clinical efficacy.
Cite this article:
Snehal Shrivastav, Rasika Rangari, Tushar Akhare, Yogita Charde, Govind Lohiya. Current Trends in Modification of Curcumin Derivatives to Improve Drug Delivery. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(2):179-4. doi: 10.52711/2231-5659.2025.00028
Cite(Electronic):
Snehal Shrivastav, Rasika Rangari, Tushar Akhare, Yogita Charde, Govind Lohiya. Current Trends in Modification of Curcumin Derivatives to Improve Drug Delivery. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(2):179-4. doi: 10.52711/2231-5659.2025.00028 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2025-15-2-13
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