Author(s): Tentu NageswaraRao, Karri Apparao, N. Krishnarao, A. Vijayalakshmi

Email(s): tnraochemistry@gmail.com

DOI: 10.5958/2231-5659.2017.00022.4   

Address: Tentu NageswaraRao1*, Karri Apparao1, N. Krishnarao1, A. Vijayalakshmi2
1Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, India.
2Department of Marine Living Resources, Andhra University, Visakhapatnam, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2017


ABSTRACT:
A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of benazepril hydrochloride and its related impurities. The chromatographic separations were achieved on (250×4.6 mm), 5.0 µm make: Symmetry Shield column employing 0.02M tetrabuthylammonium hydroxide + 0.05 % v/v acetic acid : methanol in the ratio of 50:50 (v/v) as mobile phase with isocratic at flow rate 1.0mL/min was chosen. All impurities were eluted within 30 minutes. The column temperature was maintained at 25oC and a detector wavelength of 240 nm was employed. The method was successfully validated by establishing System Suitability, Specificity, Linearity, Precision, Accuracy, Limit of detection and Limit of quantification.


Cite this article:
Tentu NageswaraRao, Karri Apparao, N. Krishnarao, A. Vijayalakshmi. A New Simultaneous HPLC Analytical method for Quantification of Benazepril Hydrochloride and its related Impurities in Bulk Drug Product. Asian J. Res. Pharm. Sci. 2017; 7(3): 135-140. doi: 10.5958/2231-5659.2017.00022.4


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DOI: 10.5958/2231-5659 


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