Author(s): Divya A. Patel, Hasumati A. Raj, Vineet C. Jain

Email(s): divyapatel388@gmail.com , drharaj@yahoo.com

DOI: 10.5958/2231-5659.2015.00004.1   

Address: Divya A. Patel*, Hasumati A. Raj, Vineet C. Jain
Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 1,     Year - 2015


ABSTRACT:
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Edaravone and Argatroban in synthetic mixture using first order derivative zero-crossing method. Edaravone showed zero crossing point at 351.00 nm while Argatroban showed zero crossing point at 280.47 nm. The dA/d? was measured at 280.47 nm for Edaravone and 351.00nm for Argatroban and calibration curves were plotted as dA/d? versus concentration, respectively. The method was found to be linear (r2>0.998) in the range of 10-35µg/ml for Edaravone at 280.47 nm. The linear correlation was obtained (r2>0.999) in the range of 10-35 µg/ml for Argatroban at 351.0 nm. The limit of determination was 1.59µg/ml and 1.87µg/ml for Edaravone and Argatroban, respectively. The limit of quantification was 4.83 µg/ml and 5.68 µg/ml for Edaravone and Argatroban, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Edaravone and Argatroban in binary mixture.


Cite this article:
Divya A. Patel, Hasumati A. Raj, Vineet C. Jain. First derivative Spectroscopic Method for Simultaneous Estimation of Edaravone and Argatroban in synthetic mixture. Asian J. Res. Pharm. Sci. 5(1): Jan.-March 2015; Page 18-26. doi: 10.5958/2231-5659.2015.00004.1


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DOI: 10.5958/2231-5659 


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