Author(s):
Urvashi Rai, Kavita Sharma, Richa Kamani, Urmila Pande, Alka Singh, Arjun Singh
Email(s):
arjunphar@gmail.com
DOI:
10.52711/2231-5659.2024.00005 
Address:
Urvashi Rai1, Kavita Sharma1, Richa Kamani1, Urmila Pande1, Alka Singh1, Arjun Singh2*
1Department of Pharmacognosy, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author
Published In:
Volume - 14,
Issue - 1,
Year - 2024
ABSTRACT:
Coronaviruses are a class of large, enveloped, positive-sensed, single-stranded RNA viruses that cause infections in the respiratory tracts of mammals such as humans, bats, and other animals. Coronavirus disease 2019 (COVID-19), also known as 2019 new coronavirus (2019-nCoV), is an agile respiratory disease caused by a novel coronavirus that was first discovered in Wuhan, China. It has now expanded to 216 nations and killed over 0.5 million people worldwide, prompting the World Health Organization (WHO) to proclaim it a pandemic. Current review focuses on the role of herbs and herbs-derived secondary metabolites in inhibiting the SARS-CoV-2 virus as well as in the management of post-COVID-19 complications. This strategy will promote and protect the use of medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been shown to prevent viral infection and to alleviate post-COVID complications such as parkinsonism, kidney and heart failure, liver and lung damage, and mental problems. We investigated mechanistic approaches of herbal medicines and their phytochemicals as antiviral and post-COVID complications by modulating immunological and inflammatory states in this review.
Cite this article:
Urvashi Rai, Kavita Sharma, Richa Kamani, Urmila Pande, Alka Singh, Arjun Singh. Natural Therapeutics against the SARS-CoV-2 Viral infection. Asian Journal of Research in Pharmaceutical Sciences. Sci. 2024; 14(1)27-3: doi: 10.52711/2231-5659.2024.00005
Cite(Electronic):
Urvashi Rai, Kavita Sharma, Richa Kamani, Urmila Pande, Alka Singh, Arjun Singh. Natural Therapeutics against the SARS-CoV-2 Viral infection. Asian Journal of Research in Pharmaceutical Sciences. Sci. 2024; 14(1)27-3: doi: 10.52711/2231-5659.2024.00005 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2024-14-1-5
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7. Jain, Shilpi, Arjun Singh, Puja Khare, D. Chanda, Disha Mishra, Karuna Shanker, and Tanmoy Karak. “Toxicity Assessment of Bacopa Monnieri L. Grown in Biochar Amended Extremely Acidic Coal Mine Spoils.” Ecological Engineering 108 (November 2017): 211–19. https://doi.org/10.1016/j.ecoleng.2017.08.039.
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9. Kumar, Balagani Sathish, Kusumoori Ravi, Amit Kumar Verma, Kaneez Fatima, Mohammad Hasanain, Arjun Singh, Jayanta Sarkar, Suaib Luqman, Debabrata Chanda, and Arvind S. Negi. “Synthesis of Pharmacologically Important Naphthoquinones and Anticancer Activity of 2-Benzyllawsone through DNA Topoisomerase-II Inhibition.” Bioorganic & Medicinal Chemistry 25, no. 4 (February 2017): 1364–73. https://doi.org/10.1016/j.bmc.2016.12.043.
10. Mishra, Disha, Jyotshna, Arjun Singh, D. Chanda, K. Shanker, and Puja Khare. “Potential of Di-Aldehyde Cellulose for Sustained Release of Oxytetracycline: A Pharmacokinetic Study.” International Journal of Biological Macromolecules 136 (September 2019): 97–105. https://doi.org/10.1016/j.ijbiomac.2019.06.043.
11. Sathish Kumar, B., Amit Kumar, Jyotsna Singh, Mohammad Hasanain, Arjun Singh, Kaneez Fatima, Dharmendra K. Yadav, et al. “Synthesis of 2-Alkoxy and 2-Benzyloxy Analogues of Estradiol as Anti-Breast Cancer Agents through Microtubule Stabilization.” European Journal of Medicinal Chemistry 86 (October 2014): 740–51. https://doi.org/10.1016/j.ejmech.2014.09.033.
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13. Singh, Aastha, Kaneez Fatima, Arjun Singh, Akansha Behl, M. J. Mintoo, Mohammad Hasanain, Raghib Ashraf, et al. “Anticancer Activity and Toxicity Profiles of 2-Benzylidene Indanone Lead Molecule.” European Journal of Pharmaceutical Sciences 76 (August 30, 2015): 57–67. https://doi.org/10.1016/j.ejps.2015.04.020.
14. Singh, Aastha, Kaneez Fatima, Ankita Srivastava, Sadiya Khwaja, Dev Priya, Arjun Singh, Girish Mahajan, et al. “Anticancer Activity of Gallic Acid Template-Based Benzylidene Indanone Derivative as Microtubule Destabilizer.” Chemical Biology & Drug Design 88, no. 5 (November 2016): 625–34. https://doi.org/10.1111/cbdd.12805.
15. Singh, Arjun, B. Sathish Kumar, Sarfaraz Alam, Hina Iqbal, Mohammad Shafiq, Feroz Khan, Arvind S. Negi, Kashif Hanif, and Debabrata Chanda. “Diethyl-4,4ʹ-Dihydroxy-8,3ʹ-Neolign-7,7ʹ-Dien-9,9ʹ-Dionate Exhibits Antihypertensive Activity in Rats through Increase in Intracellular CGMP Level and Blockade of Calcium Channels.” European Journal of Pharmacology 799 (March 2017): 84–93. https://doi.org/10.1016/j.ejphar.2017.01.044.
16. Singh, Arjun, B. Sathish Kumar, Hina Iqbal, Sarfaraz Alam, Pankaj Yadav, Amit Kumar Verma, Feroz Khan, et al. “Antihypertensive Activity of Diethyl-4,4’-Dihydroxy-8,3’-Neolign-7,7’-Dien-9,9’-Dionate: A Continuation Study in L-NAME Treated Wistar Rats.” European Journal of Pharmacology 858 (September 5, 2019): 172482. https://doi.org/10.1016/j.ejphar.2019.172482.
17. Singh, Arjun, Ipsita Mohanty, Jagmohan Singh, and Satish Rattan. “BDNF Augments Rat Internal Anal Sphincter Smooth Muscle Tone via RhoA/ROCK Signaling and Nonadrenergic Noncholinergic Relaxation via Increased NO Release.” American Journal of Physiology-Gastrointestinal and Liver Physiology 318, no. 1 (January 1, 2020): G23–33. https://doi.org/10.1152/ajpgi.00247.2019.
18. Singh, Arjun, and Satish Rattan. “BDNF Rescues Aging-Associated Internal Anal Sphincter Dysfunction.” American Journal of Physiology-Gastrointestinal and Liver Physiology 321, no. 1 (July 1, 2021): G87–97. https://doi.org/10.1152/ajpgi.00090.2021.
19. Singh, Arjun, Jagmohan Singh, and Satish Rattan. “Evidence for the Presence and Release of BDNF in the Neuronal and Non‐neuronal Structures of the Internal Anal Sphincter.” Neurogastroenterology& Motility, February 24, 2021. https://doi.org/10.1111/nmo.14099.
20. Srivastava, Ankita, Kaneez Fatima, Eram Fatima, Arjun Singh, Aastha Singh, Aparna Shukla, Suaib Luqman, et al. “Fluorinated Benzylidene Indanone Exhibits Antiproliferative Activity through Modulation of Microtubule Dynamics and Antiangiogenic Activity.” European Journal of Pharmaceutical Sciences 154 (November 1, 2020): 105513. https://doi.org/10.1016/j.ejps.2020.105513.
21. Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology; 12(4):349-0. doi: 10.52711/2231-5713.2022.00055
22. Manmohan, S., Arjun, S., Khan, S. P., Eram, S., &Sachan, N. K., 2012. Green chemistry potential for past, present and future perspectives. International Research Journal of Pharmacy, 3, 31-36.
23. Singh A, Kumar BS, Alam S, Iqbal H, Shafiq M, Khan F, Negi AS, Hanif K, Chanda D. Corrigendum to "Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits AH activity in rats through increase in intracellular cGMP level and blockade of calcium channels" [Eur. J. Pharmacol. 799 (2017) 84-93]. Eur J Pharmacol. 2017 Jul 5;806:111. doi: 10.1016/j.ejphar.2017.04.033. Erratum for: Eur J Pharmacol. 2017 Mar 15;799:84-93. PMID: 28495016.
24. Singh, A., R. Sharma, K. M. Anand, S. P. Khan, and N. K. Sachan. "Food-drug interaction." International Journal of Pharmaceutical & Chemical Science 1, no. 1 (2012): 264-279.
25. Singh, A., Chanda, D., & Negi, A. S. (2018). Antihypertensive activity of Diethyl-4, 4'-dihydroxy-8, 3'-neolign-7, 7'-dien-9, 9'-dionate through increase in intracellular cGMP level and blockade of calcium channels (VDCC) and opening of potassium channel and in vivo models (SHRs and L-NAME induced hypertension). In Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) (pp. PO1-2). Japanese Pharmacological Society.
26. Yadav P, Iqbal H, Kumar K, Kumar P, Mishra P, Singh A, Pal A, Mukhopadhay P, Negi AS, Chanda D. "Novel naphthoquinone 2-benzyllawsone protects against sepsis through reversal of vascular hyporeactivity and hypotension, inhibition of inflammation and anti-microbial activity in Swiss albino mice." European Journal of Pharmacology; 2022 Feb 15; 917:174757. DOI: https://doi.org/10.1016/j.ejphar.2022.174757
27. Singh A., Singh J, Rattan S. "Evidence for the presence and release of BDNF in the neuronal and non-neuronal structures of the internal anal sphincter." Neurogastroenterol Motility. 2021 Feb 24;e14099. DOI: https://doi.org/10.1111/nmo.14099
28. Singh, Arjun, B. Sathish Kumar, Hina Iqbal, Sarfaraz Alam, Pankaj Yadav, Amit Kumar Verma, Feroz Khan, et al. "Antihypertensive Activity of Diethyl-4,4'-Dihydroxy-8,3'-Neolign-7,7'-Dien-9,9'-Dionate: A Continuation Study in L-NAME Treated Wistar Rats." European Journal of Pharmacology 858 (2019): 172482. DOI: https://doi.org/10.1016/j.ejphar.2019.172482
29. Hamid, A. A., Tanu Kaushal, Raghib Ashraf, Arjun Singh, Amit Chand Gupta, Om Prakash, Jayanta Sarkar, et al. "(22β,25R)-3β-Hydroxy-Spirost-5-En-7-Iminoxy-Heptanoic Acid Exhibits Anti-Prostate Cancer Activity through Caspase Pathway." Steroids 119 (2017): 43-52. DOI: https://doi.org/10.1016/j.steroids.2017.01.001
30. Singh, Arjun, B. Sathish Kumar, Sarfaraz Alam, Hina Iqbal, et al. "Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits antihypertensive activity in rats through increase in intracellular cGMP level and blockade of calcium channels." European Journal of Pharmacology 799 (2017): 84-93. DOI: https://doi.org/10.1016/j.ejphar.2017.01.044
31. Shilpi Jain, Arjun Singh, Puja Khare, D. Chanda, Disha Mishra, Karuna Shanker, Tanmoy Karak. "Metal bioavailability and toxicity of Bacopa monnieri grown in Biochar amended mine waste contaminated soil." Ecological Engineering, 108 (2017): 211-219. DOI: https://doi.org/10.1016/S2095-4964(16)60241-8
32. Gautam, Yashveer, Sonam Dwivedi, Ankita Srivastava, Hamidullah, Arjun Singh, et al. "2-(3′,4′-Dimethoxybenzylidene) tetralone Induces anti-breast cancer activity through Microtubule Stabilization and Activation of Reactive Oxygen Species." RSC Advances 6, 40 (2016): 33369-79. DOI: https://doi.org/10.1039/C6RA02663J
33. Chanda, Debabrata, Jesus Prieto-Lloret, Arjun Singh, Hina Iqbal, Pankaj Yadav, Vladimir Snetkov, and Philip I. Aaronson. "Glabridin-induced vasorelaxation: Evidence for a role of BKCa channels and cyclic GMP." Life Sciences 165 (2016): 26-34. DOI: https://doi.org/10.1016/j.lfs.2016.09.018
34. Hamid, A. A., Mohammad Hasanain, Arjun Singh, BalakishanBhukya, et al. "Synthesis of novel anticancer agents through opening of spiroacetal ring of Diosgenin." Steroids 87 (2014): 108-18. DOI: https://doi.org/10.1016/j.steroids.2014.05.025
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36. Tim F. Dorweiler, Arjun Singh, Richard N Kolesnick, Julia V. Busik; Inhibition of ceramide rich platforms by anti-ceramide immunotherapy prevents retinal endothelial cell damage and the development of diabetic retinopathy.. Invest. Ophthalmol. Vis. Sci. 2023;64(8):941.
37. Singh, Arjun, Rupendra Kumar, and Sachin Sharma. "Natural products and Hypertension: Scope and role in Antihypertensive Therapy." Asian Journal of Nursing Education and Research 13.2 (2023): 162-166.DOI:10.52711/2349-2996.2023.00035
38. Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2):141-4. doi: 10.52711/2349-2996.2023.00031
39. Singh, Arjun; Kumar, Rupendra. “An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols”. Asian Journal of Research in Chemistry; Raipur Vol. 16, Iss. 1, (Jan/Feb 2023): 8-12. DOI:10.52711/0974-4150.2023.00002
40. Singh, Arjun. “Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads”. Asian Journal of Research in Chemistry; Raipur Vol. 16, Iss. 1, (Jan/Feb 2023): 43-48. DOI:10.52711/0974-4150.2023.00008.
41. Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1):43-8. doi: 10.52711/0974-4150.2023.00008