Author(s):
K. Nagasree, K. Pallavi, Ramya Sri S
Email(s):
nagasreepharmacy@gmail.com
DOI:
10.52711/2231-5659.2023.00003 
Address:
K. Nagasree1*, K. Pallavi1, Ramya Sri S2
1Department of Pharmaceutics, Samskruti College of Pharmacy, Affiliated to JNTUH University, Hyderabad 501301, Telangana, India.
2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad – 500 007, Telangana, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 1,
Year - 2023
ABSTRACT:
Niosomes are the non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants. These are the promising vehicles for effective transdermal drug delivery. The present research work was aimed to develop niosomal-based transdermal Clozapine patch containing a stable formulation with improved drug permeation. Niosomes were prepared by solvent casting method. All the formulations were evaluated for vesicle size, zeta potential and percent entrapment efficiency. All the patches were then characterized for thickness, folding endurance, drug content determination, Flatness, and in vitro permeation studies. F3 formulation having optimum vesicle size (2.6?m), highest zeta potential (-32.56mV) and maximum percent entrapment efficiency (98.09%) was selected as optimized formulation. The transdermal patch was prepared using solvent casting method from the optimised niosomes formulation F3 formulation. The prepared optimised niosomes F3 formulation were loaded into the patch formulation. Patches loaded with niosomes (F3NT3) showed 95.78 % cumulative amount of drug permeated. The optimized formulation (F3NT3) followed first order release kinetics.
Cite this article:
K. Nagasree, K. Pallavi, Ramya Sri S. Preparation and Evaluation of Niosomal Transdermal Patch of Clozapine. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(1):13-8. doi: 10.52711/2231-5659.2023.00003
Cite(Electronic):
K. Nagasree, K. Pallavi, Ramya Sri S. Preparation and Evaluation of Niosomal Transdermal Patch of Clozapine. Asian Journal of Research in Pharmaceutical Sciences. 2023; 13(1):13-8. doi: 10.52711/2231-5659.2023.00003 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2023-13-1-3
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