Cancer is second leading cause of death across globe with 9.6 million deaths in 2018 as reported by WHO. Cancer is uncontrolled growth of cells which results into malignant tumours and then leads to death if not treated on time. Colorectal cancer ranks third among the cancer related deaths in western hemisphere. It is leading health problem among the geriatric patients mostly above the age of 50. Early screening and diagnosis amongst these populations is the major step towards prevention and cure of cancer. It starts from formation of polyps due to diet and hereditary factors which further invade the inner layers of the colon and the rectum leading to a major health problem. Colorectal cancer detection and screening too is challenging one, and its mandatory for an individual for undergoing screening tests like faecal occult blood test (FOBT) for the one approaching the age of 50 and above and the one who has a family history of colorectal cancer as stated by CDC (Centre for Disease Control and Prevention).Treatment and prevention of colorectal cancer has become a challenge for health professionals to tackle it, and is in practice done with surgery, radiotherapy and chemotherapy.
Cite this article:
Rahul Ashok Sachdeo, Manoj S. Charde, Ritu D. Chakole. Colorectal Cancer: An Overview. Asian J. Res. Pharm. Sci. 2020; 10(3):211-223. doi: 10.5958/2231-5659.2020.00040.5
1. Lauren Byrne, MPHP 439 – Online Textbook Chapter, December 3, 2008 Colorectal Cancer
2. www.mayoclinic.org: https://www.mayoclinic.org/diseases-conditions/colon-cancer/symptoms-causes/syc-20353669. 1998-2018 Mayo Foundation for Medical Education and Research (MFMER).
3. American Cancer Society. Colorectal Cancer Facts and Figures 2014-16. Atlanta, Ga: American Cancer Society; 2014. “About Colorectal Cancer”.
4. Anne B Ballinger, Clive Anggiansah: Colorectal cancer. NCBI BMJ. 2007 Oct 6; 335(7622): 715–718.
5. American Cancer Society. Colorectal Cancer Facts and Figures 2014-16. Atlanta, Ga: American Cancer Society; 2014.“Causes, Risk Factors, and Prevention”.
6. Rahul P. Phate's “Anatomy Physiology and Health Education”, 3rd Edition, 2005, Career Publication, page number: 288-290.
7. Harsh Mohan's “Textbook of Pathology” , 7th Edition, 2015, Jaypee Brothers Medical Publishers (P) Ltd., New Delhi, page number: 563-571.
8. Jing Ma,2 Meir J. Stampfer, Edward Giovannucci, Carmen Artigas, David J. Hunter, Charles Fuchs, Walter C. Wfflett, Jacob Seihub, Charles H. Hennekens, and Rima Rozen. Methylenetetrahydrofolate Reductase Polymorphism, Dietary Interactions, and Risk of Colorectal Cancer.
9. Ritesh Kumar, Jennifer L. Herold, John Taylor, Juan Xu and Yi Xu: Variations among Streptococcus gallolyticus subsp. gallolyticus strains in connection with colorectal cancer, Scientific Reports Volume 8, Article Number: 1514(2018).
10. Remi Murase, Yoshitaka Taketomi, Yoshimi Miki, Yasumasa Nishito, Moe Saito, Kiyoko Fukami, Kei Yamamoto and Makoto Murakami: Group III Phospholipase A2 Promotes Colitis And Colorectal Cancer. Nature.com, Scientific Reports 7, Article number: 12261 (2017).
11. Russell C. Langan1, John E. Mullinax2, Manish T. Raiji1, Trevor Upham1, Thomas Summers3, Alexander Stojadinovic4,5, Itzhak Avital6.Colorectal Cancer Biomarkers and the Potential Role of Cancer Stem Cells. Journal of Cancer 2013; 4(3): 241-250.
12. Jiekai Yu, Xiaohui Zhai, Xiaofen Li, Chenhan Zhong, Cheng Guo, Fuquan Yang, Ying Yuan and Shu Zheng: Identification of MST1 as a potential early detection biomarker for colorectal cancer through a proteomic approach. Nature.com, Scientific Reports 7, Article Number: 14265 (2017).
13. American Cancer Society. Colorectal Cancer Facts and Figures 2014-16. Atlanta, Ga: American Cancer Society; 2014.“Treating Colorectal Cancer”.
14. American Cancer Society. Colorectal Cancer Facts and Figures 2014-16. Atlanta, Ga: American Cancer Society; 2014. “Colorectal Cancer Early Detection, Diagnosis, and Staging”.
15. American Cancer Society. Colorectal Cancer Facts and Figures 2014-16. Atlanta, Ga: American Cancer Society; 2014. “After Colorectal Cancer Treatment”.