Author(s):
Vaishali Vijay Pagar, Mitesh P. Sonawane, Parag D. Kothawade, Pratibha K. Pagar, Shamal S. Patil
Email(s):
pagarvaishali40@gmail.com
DOI:
10.52711/2231-5659.2024.00002
Address:
Vaishali Vijay Pagar*, Mitesh P. Sonawane, Parag D. Kothawade, Pratibha K. Pagar, Shamal S. Patil
Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Nashik 423501, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 1,
Year - 2024
ABSTRACT:
Background: Coenzyme Q10 has a role in mitochondrial transport system and can be utilized as a supplement in migraine prevention. This study's objective is to assess Coenzyme Q10's effectiveness when used in conjunction with conventional medications to prevent migraines. Adding 300mg of coenzyme Q10 each day to prescription medications, while another group of patients continued receiving standard care. Over the course of a three-month treatment period, data on attack frequency, headache pain intensity, monthly migraine days, and associated symptoms like nausea, vomiting, phonophobia, and photophobia were analyses. Ubidecarenone, a medicinal component. The goal is to produce Ubidecarenone in a 300 mg chew-able tablet form. In vitro release studies and organoleptic properties, such as taste and flavour, will be evaluated. investigations in the early stages, tests for medicine excipient compatibility, and analyses of the water content Quality Assurance for the Process Hausner's Ratio, Bulk Density, Tapped Density, Comprehensibility Index, and Angle of Repose for calculating derived properties for medications and mixtures. ingredients that have been optimised for their concentrations, such as tastes, sweeteners, disintegrants, wetting agents, glidants, and lubricants. putting the best possible ingredients together to make a chew able pill. Evaluation of chewable tablets for post compression parameters including uniformity of weight, thickness, hardness, brittleness, friability, dissolution, assay, and in vitro drug release properties. An evaluation of the optimised batch's palatability is required. The intention is to create chewable tablets of ubidecarenone. Method: The wet granulation method is used to make chewable tablets of ubidecarenone. Mannitol is used as a diluent, crospovidone as a disintegrant agent, sodium starch as a disintegrate agent, saccharin sodium as a sucrose sweetener, orange flavour, peppermint oil as a flouring agent, and colloidal silicon dioxide as a gliding. The Ubidecarenone (300 mg) is one of the best first-line treatments for migraine prevention.
Cite this article:
Vaishali Vijay Pagar, Mitesh P. Sonawane, Parag D. Kothawade, Pratibha K. Pagar, Shamal S. Patil. Formulation Development and Evaluation of Ubidecarenone Chewable Tablet. Asian Journal of Research in Pharmaceutical Sciences. Sci. 2024; 14(1):6-0. doi: 10.52711/2231-5659.2024.00002
Cite(Electronic):
Vaishali Vijay Pagar, Mitesh P. Sonawane, Parag D. Kothawade, Pratibha K. Pagar, Shamal S. Patil. Formulation Development and Evaluation of Ubidecarenone Chewable Tablet. Asian Journal of Research in Pharmaceutical Sciences. Sci. 2024; 14(1):6-0. doi: 10.52711/2231-5659.2024.00002 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2024-14-1-2
REFERENCE:
1. Bhatt SK, Kedarnagalakshman M, Sharma M. THE Role of Chewable Tablets: An Overview. Asian Journal of Pharmaceutical Research and Development. 2021; 9(4): 141-6.
2. Han S, Jia X, Zhu R, Cao Y, Xu Z, Meng Y. Gastroenterology nurse prescribing in China: A Delphi method. Journal of Advanced Nursing. 2021; 77(3): 1228-43.
3. Kushwaha N, Jain A, Jain PK, Khare B, Jat YS. An Overview on Formulation and Evaluation Aspects of Tablets. Asian Journal of Dental and Health Sciences. 2022; 2(4): 35-9.
4. Bhatt SK, Kedarnagalakshman M, Sharma M. THE Role of Chewable Tablets: An Overview. Asian Journal of Pharmaceutical Research and Development. 2021; 9(4): 141-6.
5. Ghurghure SM, Pathan MS, Ramesh p. formulation and evaluation of chewable tablets containing aqueous extract of zingiber officiale.
6. www.solid dosage forms.com
7. Kanwar K. Tablet in Tablet-An Innovative and Pragmatic Approach in Tableting Technology. Asian Journal of Pharmaceutics (AJP). 2022;16(2).
8. Kodag S, Gaikwad S, Mali S, Mali A. An overview on mini tablets. Asian Journal of Pharmacy and Technology. 2022; 12(3): 266-71.
9. Gopale O, Jethawa S, Shelke S. Medicated lozenges: a review. Asian Journal of Pharmaceutical Research and Development. 2022; 10(2): 129-34.
10. Sharma SK, Singh A, Bhandari A, Singh S, Singh S. Development and Evaluation of Chewable Tablets of Calcium and Vitamin D. Asian Journal of Pharmaceutical Research and Development. 2020; 8(3): 232-4.
11. Salman M, Qazi MA, Haq A, Khan N, Shaikh S. Formulation, optimization and evaluation of drotaverine HCl mini tablet. Asian Journal of Pharmacy and Technology. 2022; 12(1): 6-12.
12. Thulluru A, Madhavi C, Nandini K, Sirisha S, Spandana D. Co-processed excipients: New era in pharmaceuticals. Asian Journal of Research in Pharmaceutical Science. 2019; 9(1): 1-5.
13. Maskare RG, Thakre SD, Patle OD, Vishwakarma SS, Dahake DN, Jagnit RJ, Rahangdale RS. Novel Formulation for Treatment of Mouth Ulcer. Asian Journal of Pharmacy and Technology. 2023; 13(1).
14. Khan Z, Khan H, Shah MA. Antioxidant activity of coenzyme-Q; bright and dark side. InAntioxidants Effects in Health 2022: 323-340. Elsevier.
15. Sushir C, Kilor V, Rewatkar A. Pediatric Drug Development Process: A Review. Asian Journal of Pediatric Research. 2023; 12(2): 23-34.
16. Aleksandr C. Clinical and Functional Rationale for the Use of Inlays from Various Types of Material. Central Asian Journal of Medical and Natural Science. 2023; 4(1): 12-5
17. Constantinescu R, McDermott MP, DiCenzo R, de Blieck EA, Hyson HC, Beal MF, Bednarczyk EM, Bogdanov M, Metakis LJ, Browne SE, Lorenzo BJ. A randomized study of the bioavailability of different formulations of coenzyme Q10 (ubiquinone). Journal of Clinical Pharmacology. 2007; 47(12): 1580-7.