Author(s): Shivani Choudhary, Pravin Kumar, Vinay Pandit, Mahendra Singh Ashawat

Email(s): shivanichoudhary9651@gmail.com

DOI: 10.5958/2231-5659.2021.00010.2   

Address: Shivani Choudhary, Pravin Kumar, Vinay Pandit, Mahendra Singh Ashawat
Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2021


ABSTRACT:
To overcome the problems like absorption of drug, hepatic first pass metabolism, drug targeting to specific organ, a novel approach is developed for delivery of drug i.e Insitu Nasal drug delivery system. Insitu based gel delivery system can bypass the blood brain barrier and deliver the drug to the desired site. Insitu gelling systems are liquid at room temperature however experience gelation when in contact with body fluids. Mucoadhesive insitu nasal gel have increase the residence time in the nasal cavity. Insitu gel development happens because of one or mix of various upgrades like pH change, temperature modulation and solvent exchange. The insitu gel formulations have several advantages like sustained and prolonged action as compare to conventional drug delivery system. This review will be focused on insitu based gels, various aspects of nasal anatomy and physiology, mechanism of nasal drug absorption, different components that impact nasal medication ingestion, assessment of nasal gel.


Cite this article:
Shivani Choudhary, Pravin Kumar, Vinay Pandit, Mahendra Singh Ashawat. Mucoadhesive Insitu nasal Gel: A Promising Approach. Asian J. Res. Pharm. Sci. 2021; 11(1):58-64. doi: 10.5958/2231-5659.2021.00010.2

Cite(Electronic):
Shivani Choudhary, Pravin Kumar, Vinay Pandit, Mahendra Singh Ashawat. Mucoadhesive Insitu nasal Gel: A Promising Approach. Asian J. Res. Pharm. Sci. 2021; 11(1):58-64. doi: 10.5958/2231-5659.2021.00010.2   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2021-11-1-10


1.      Mahakalkar NG, Upadhye KP. Zolmitriptan nasal insitu gel using sterculia foetida linn gum as natural mucoadhesive polymer. International Journal Pharma Sciences. 2013; 22(2): 206-213.

2.      Gavini E, Hegge AB, Rassu G, et al. Nasal administration of carbamazepine using Chitosan microspheres: In vitro/in vivo studies. Int J Pharm. 2006, 307: 9-15.

3.      Sarasija S, Shyamala B. Nasal drug delivery: An overview, Indian journal pharm. Sci. 2005, 67(1): 19-25.

4.      Swamy N G N, Abbas Zaheer. Mucoadhesive in situ gels as nasal drug delivery systems, Asian Journal of Pharmaceutical Sciences 2012, 7 (3): 168-180.

5.      Wang X, Chi N, Tang X. Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting. Eur J Pharm Biopharm. 2008, 70: 735-740.

6.      Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci. 2000, 11: 1-18.

7.      Yildiz ozsoy, Sevgi gungor and Eradal cevher. Nasal delivery of high molecular weight drugs. Molecules, 2009 sep ;14(9): 3754-3779.

8.      Swamy N.G.N and Z. Abbas. Prepartion and invitro characterization of mucoadhesive hydroxypropyl guar microspheres containing amlodipine besylate for nasal administration, Indian J Pharm. Sci, 2011, 73(6): 608-614.

9.      Singh AK, Singh A, Madhav NVS. Nasal cavity: a promising transmucosal platform for drug delivery and research approaches from nasal to brain targetting. Journal of Drug Delivery and Therapeutics. 2012; 2(3): 22-33.

10.   Sheth S Nirav , Mistry B Rajan . A Review: Nasal Drug Delivery System. Research J. Pharm. and Tech. 4(3): March 2011; 349-355.

11.   Mehta MR, Surve SA et al. Novel nasal In situ gelling system for treatment of sinusitis. Ind J Pharm Sci. ,2010;59: 153-180.

12.   Chein YW and Chang JF. Nasal systemic drug delivery, 2nd Edn, Marcel Dekker Inc, New York, Basel, 1989, 1-77.

13.   Sheth S Nirav, Mistry B Ranjan. A Review: Nasal drug delivery system. Research J. Pharm. and Tech..4(3): March 2011; 349-355.

14.   Ramya D, Abhirami M, Brindha R, Gomathi S, Vedhahari B.N. In-Situ Gelling System–Potential Tool for Improving Therapeutic Effects of Drug, International Journal of Pharmacy and Pharmaceutical Sciences, 2013; 5(3): 27-30.

15.   Bajpai V. In situ Gel Nasal Drug Delivery System A Review, International Journal of Pharma Sciences, 2014; 4: 577-580.

16.   Aishwarya J Jadhav, Sheetal B Gondkar, Ravindra B Saudagar. A Review on nasal drug delivery system. World journal of pharmacy and pharmaceutical sciences, (WJPPS), 2014; 3(8): 231-254.

17.   Dey S, Mahanti B, Mazumder B, Malgope A, Dasgupta S. Nasal drug delivery: An approach of drug delivery through nasal route, Pelagia Research Library,2011; 2(3): 94-106.

18.   G.P. Kumar, S. Kiran. Strategies and prospects of nasal drug delivery systems. International Journal of Pharmaceutical Sciences and Research, 2012; 3(3): 648-658.

19.   Devi R, Chaudhary A, Pandit V. Mucoadhesive in situ Nasal Gel- A Novel Approach, Journal of Advanced Drug Delivery, 2014; 1(6).

20.   Rokade M., Tambe B., Ruparel. In situ Gel-Sustained Nasal Drug Delivery. International Journal of Pharmaceutical Sciences Research, 2015; 6(12): 4958-4969.

21.   Modi P R, Patel G V, Daslaniya D J, Patel U L, Bhimani B V. Nose to Brain Drug Delivery System: A review. Research J. Pharm. and Tech.6(4): April 2013; 345-350.

22.   Verma P, Thakur A.S, Deshmukh K. Routes of drug administration. Int J Pharm Stud Res, 2010;1(1):54-9.

23.   Nair S.C, John M.S, Anoop K.R, Insitu gel: An innovative approach for safe and sustained nasal drug delivery, international journal of pharmaceutical science review and research, 2014;24; 1-7.

24.   Panchal D.R, Patel U.L, Bhimani B.V, Danslaniya D.J, Patel G.V, Nasal Insitu gel: A novel drug delivery system, Inter. J. for Pharma research scholar, 199(2), 2012, 457-473.

25.   Paul Asha, K.M Fathima, Nitheesh Antony, Nair C Sreeja, Intranasal Route: A Putative Strategy for Novel Drug Delivery, Int. J. Pharm. Sci. Rev. Res., 42(1), January - February 2017; Article No. 04, Pages: 20-28.

26.   Nielsen HW, Bechgaard E, Twile B, Didriksen E, Sorensen H, Intranasal administration of different liquid formulations of bumetanide to rabbits, International Journal of Pharmaceutics, 2000, 204(1-2), 35-41.

27.   Arora P, Sharma S, Garg S, Permeability issues in nasal drug delivery, Drug Discovery Today, 2002, 7(18), 967-975.

28.   Marttin E, Schipper NGM, Verhoef JC, Merkus FWHM. Nasal mucociliary clearance as a factor in nasal drug delivery, Advance Drug Delivery Reviews, 1998, 29(1-2), 13-38.

29.   Saudagar R. B., Khandbahale. Insitu Nasal Gel- A Review. Asian journal of research in pharmaceutical sciences, 2017; 7(1): 23-32.

30.   Jadhav KR, Gambhire MN, Shaikh IM, Kadam VJ, Pisal SS. Nasal drug delivery system: Factors affecting and applications. Current Drug Therapy, 2007, 2(1), 27-38.

31.   Raval Sanjay, Vyas Jigar, Parmar Vijay, Raval Dhaval. A Review on In-Situ Polymeric Drug Delivery System. International Journal of Drug Formulation and Research, 2011; 2(4): 143-168.

32.   J.S. Paun, A. A. Bagada, and M. K. Raval. Nasal drug delivery as an effective tool for brain targeting. International Journal of Pharmaceutical and Applied Sciences, 2010; 1(2): 43-55.

33.   Rahisuddin, P. K. Sharma, G. Garg, and M. Salim. Review on nasal drug delivery system with recent advancement. International Journal of Pharmacy and Pharmaceutical Sciences, 2011; 3(2): 1-5.

34.   Aurora J. Development ofNasal Delivery Systems. A Review.Drug Deliv Technol 2002; 2(7): 1‐8.

35.   Sarfraz Khan. Review: In-Situ gelling system. Journal of innovations in Pharmaceuticals and biological sciences (JIPBS), 2014; 1(2): 88-91.

36.   Fisher, AN, Illum, L, Davis, SS, Schacht, EH. Di-iodo-L-tyrosinelabelled dextrans as molecular size markers of nasal absorption in the rat. J Pharm Pharmacol. .1992;44;550–554.

37.   Garg T, Goyal AK. Iontophoresis: drug delivery system by applying an electrical potential across the skin. Drug Deliv Lett. 2012; 2:270–280.

38.   Moon R S, Mitkare S S, etal. Intranasal route: A novel approach for CNS delivery. Research J. Pharm. and Tech. 3(4): Oct.-Dec.; 970-978.

39.   Goyal AK, Rath G, Garg T. Nanotechnological approaches for genetic immunization. DNA RNA Nanobiotechnol Med Diagnos Treatment Dis.2013;67–120.

40.   Moon R S, Mitkare S S, etal. Intranasal route: A novel approach for CNS delivery. Research J. Pharm. and Tech. 3(4): Oct.-Dec.; 970-978.

41.   Goyal G, Garg T, Rath G, Goyal AK. Current nanotechnological strategies for an effective delivery of drugs in treatment of periodontal disease. Crit Rev Ther Drug Carrier Syst.2014; 31:89–119.

42.   Joshi D, Garg T, Goyal AK, Rath, G. Development and characterization of novel medicated nanofibers against periodontitis. Curr Drug Deliv. 2014;363-377.

43.   Johal HS, Garg T, Rath G, Goyal AK. Advanced topical drug delivery system for the management of vaginal candidiasis. Drug Deliv. 2016;23(2):1–550-63.

44.   Saudagar R. B., Kulkarni M. Mita. Review on in-situ Nasal Gel Drug Delivery system. Research J. Pharm. and Tech. 2017; 10(6): 1870-1876.

45.   Hussain T, Garg T, Goyal AK, Rath G. Biomedical applications of nanofiber scaffolsds in tissue engineering. J Biomater Tissue Eng. 2014; 4:600–623.

46.   J.U Kute, A.B Darekar, R.B Saudagar. A Review: In-Situ Gel-Novel approach for nasal delivery. World journal of pharmacy and pharmaceutical sciences, 2014; 3(1): 187-203.

47.   Ram Chan Dhakar, Sheo Datta Maurya, Vijay K Tilak, Anish k Gupta, A Review on Factor Affecting The Design of Nasal Drug Delivery System, Int. J. Drug Delivery, 2011; 3: 194-208.

48.   Anoop KR, Sreeja CN, Mable SL. Insitu gel: An innovative approach for safe and sustained nasal drug delivery. International Journal Pharma Sciences. 2014; 24(1): 1-7.

49.   Wagh M P, Joshi O U, Patel J S, Jain V R. Thiomers: A new generation of mucoadhesive polymers. Research J. Pharm. and Tech.2(2): April-June,2009; 250-255.

50.   Malekar S. Nikita, Gondkar S. B., Saudagar R. B. Insitu Nasal Gel: A Review. Res. J. Pharm. Dosage Form and Tech.; 2015; 7(4): 285-293.

51.   Tyagi S, Sharma N, Sharma PK. A review on application of natural bioadhesive polysaccharides for intranasal drug delivery. Int.j.a.ps.bms. 2012; 1(2): 80-94.

52.   Sadaugar B. Ravinder, Deore B. Sonika. In-situ Nasal Gel: An Overview. Res. J. Pharm. Dosage Form and Tech.;2016;8(1): 09-14.

53.   Saneesh V Ganga, Sujith Abraham. A Review: In-Situ Drug Delivery System. International Journal of Universal Pharmacy and Bio-Sciences, 2014; 3(4): 135-149.

54.   Miyazaki S, Kawasaki N, Kubo W. Comparison of in situ-gelling formulations for the oral delivery of cimetidine. Int J Pharm.2001;220(1-2):161-8.

55.   Nerkar TS, Gujarathi NA, Rane BR, Bakliwal SR, Pawar SP. Insitu gel: novel approach in sustained and controlled drug delivery system. An International Journal of Pharmaceutical Sciences 2013; 4(4): 1-18.

56.   Pathan V, Chudiwal V, Farooqui I, Shingare P. Formulation design and evaluation of nasal insitu gel as a novel vehicle for azelastine hydrochloride. International Journal of Drug Delivery. 2013; 5: 284-290.

57.   Uttarwar S. Formulation and development of insitu gelling system for nasal administration for an antiemetic drug ondansetron hydrochloride by using pluronics 127p and pluronics 68. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012; 3(3): 1103-1118.

58.   Pradnya M Khandagale, Manisha M. Rokade, Dipti G. Phadtare. Formulation Development and Evaluation of Nasal in-situ Gel of Hydrocortisone. Asian J. pharm. Tech. 2018; 8(2):92-102.

59.   Malekar S. Nikita, Gondkar B. Sheetal, etal. Development of Naratriptan Hydrochloride In-situ Nasal Gel. Research J. Pharm. and Tech.,2017; 10(4): 979-985.

60.   Chavan P. Dhole S., Yadav M. nasal drug delivery system: a review-world journal of pharmacy and pharmaceutical sciences, 2014; 3(12): 598-617.

61.   Patil P. R, Salve V. K, Thorat R.U, Puranik P.K, Khadabadi S.S. A Review: Modern Encroachment and provocation in Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Research, 2013; 4(7): 2569-2575.

62.   Raval Sanjay, Vyas Jigar, Parmar Vijay, RavalDhaval. A Review on In-Situ Polymeric Drug Delivery System. International Journal of Drug Formulation and Research, 2011; 2(4): 143-168

63.   More A B, Mene RH, Pawar Kr, Misal SN et al, A review on insitu nasal gel drug delivery system. Int. J. Pharm. Sci.2015:33(1):199-207.

Recomonded Articles:

Author(s): Lakshmi Prasanna J., Deepthi B., Rama Rao N.

DOI:         Access: Open Access Read More

Author(s): Mohammad Yaqub Khan, Irfan Aziz, Imtiyaz Ahmad, Maryada Roy

DOI: 10.5958/2231-5659.2015.00029.6         Access: Open Access Read More

Author(s): Amit Roy, Ananta Choudhury, Tapan Kishor Nayak

DOI:         Access: Open Access Read More

Author(s): Subhashis Debnath, T. H. Harish Kumar

DOI: 10.5958/2231-5659.2020.00023.5         Access: Open Access Read More

Author(s): Shivani Choudhary, Pravin Kumar, Vinay Pandit, Mahendra Singh Ashawat

DOI: 10.5958/2231-5659.2021.00010.2         Access: Open Access Read More

Author(s): Ghorpade Arti Changdev, S. S. Siddheshwar

DOI: 10.52711/2231-5659.2024.00009         Access: Open Access Read More

Author(s): Pankaj B. Bhogam, Sushant A. Gharal, Tushar B. Patil, Aarti A. Varne, Priyanka S. Lad

DOI: 10.52711/2231-5659.2023.00059         Access: Open Access Read More

Author(s): Fathima Namzi, Kathirvel S, Raja Rajeswari K

DOI: 10.52711/2231-5659.2024.00032         Access: Closed Access Read More

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.52711/2231-5659 


Recent Articles




Tags