Author(s):
Irfan Ansari, Sachin Bhusari, Avinash Chaudhary, Gaurav Shrangare
Email(s):
ansari.irfanaamer@gmail.com
DOI:
10.5958/2231-5659.2020.00044.2 
Address:
Irfan Ansari*, Sachin Bhusari, Avinash Chaudhary, Gaurav Shrangare
Pharmaceutical Technology Division, Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431001, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 10,
Issue - 4,
Year - 2020
ABSTRACT:
The present research was engrossed on the formulation and evaluation of sustained release pellets of Zidovudine (ZVD). ZVD is first antiretroviral drug and well-known orally accepted drug. It is nucleoside reverse transcriptase inhibitor (NRTI) which has activity against Human immunodeficiency virus type 1 (HIV-1) or AIDS related complex. The Zidovudine sustained release pellets was formulated by using extrusion and spheronization technique. The formulations were analyzed for its size distribution, entrapment efficiency and surface morphology, and evaluated for its physical parameter, morphological parameters, entrapment efficiency, followed by in vitro, studies. ZVD pellets showed good micromeritic properties with angle of repose was less than 25°, Carr’s index and Hausner’s ratio were also less than 21 and 1.25, respectively. The total drug content of pellets formulations was found to be 96.38±0.1%. In vitro release of Zidovudine pellets was 92.35±0.7% after 24 hrs, which shows good release of pellets.
Cite this article:
Irfan Ansari, Sachin Bhusari, Avinash Chaudhary, Gaurav Shrangare. Formulation and Evaluation of sustained release pellets of Zidovudine by using Extrusion and Spheronization Technique. Asian J. Res. Pharm. Sci. 2020; 10(4):241-247. doi: 10.5958/2231-5659.2020.00044.2
Cite(Electronic):
Irfan Ansari, Sachin Bhusari, Avinash Chaudhary, Gaurav Shrangare. Formulation and Evaluation of sustained release pellets of Zidovudine by using Extrusion and Spheronization Technique. Asian J. Res. Pharm. Sci. 2020; 10(4):241-247. doi: 10.5958/2231-5659.2020.00044.2 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2020-10-4-2
REFERENCES:
1. Vyas SP, Khar KK. Controlled drug delivery concepts and advances, CBS Pub, 2002, 1-12.
2. Ghebre-Sellassie I and Knoch A. Pelletisation techniques Encyclopedia of Pharmaceutical Technology, Marcel Dekker Inc, New York, 1995, 369-396.
3. Jamila Hamdani J. Andre, Moes, Karim Amighi. Physical and thermal characterization of precirol® and compritol® as lipophilic glycosides used for the preparation of controlled release matrix pellets. Int. J. Pharm, 2003, 260, 47-57.
4. Trivedi NR, Rajan MG, Johnson JR, Shukla AJ. Pharmaceutical approaches to preparing pelletized dosage forms using the extrusion-spheronisation process. Crit. Ther. Drug Carr. Syst, 2007, 24, 1-40.
5. Cosijins A, Nizet D, Nikolokakis I. Porous pellets as drug delivery system. Drug Dev Ind Pharm, 2009, 35(6), 655-62.
6. Takayama K, Nagai T. Novel computer optimization methodology for pharmaceutical formulations investigated by using sustained-release granules of indomethacin. Chem. Pharm. Bull, 1989, 37, 160-7.
7. Chowdhary KPR, Srinivasa Y. Mucoadhesive Microcapsules of Glipizide. Ind J Pharm Sci, 2003, 65, 279.
8. Wong TW, Chan LW, Lee HY, Heng PW. Release characteristics of pectin microspheres prepared by an emulsification technique. J. Microencapsulation, 2002, 19, 511-22.
9. United States of Pharmacopoeia 29 National formulary 24 (USP29–NF24) Supplement 1, is current from April 1, 2006 through July 31.
10. Du Pasquier AA. Differential Scanning Calorimetry studies of lithium ion and the reactivity of carbon anodes in plastic lithium ion batteries. J. Electrochem. Sci, 1998, 145 (2), 472-477.
11. Deasy PB, Law MFL. Use of extrusion spheronization to develop an improved oral dosage form of indomethacin. Int. J. Pharm, 1997, 148, 201-9.
12. Yan X, Gemeinhart RA. Cisplatin delivery from Poly (acrylic acid-co-methyl methacrylate) microparticles. J. Control Release, 2005, 106, 198–208.