Author(s): Sirisha, Praveena R.

Email(s): anjalisiri20@gmail.com

DOI: 10.5958/2231-5659.2020.00038.7   

Address: Sirisha, Praveena R.
Sree Venkateswawa University of Pharmaceutical Sciemces.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2020


ABSTRACT:
The substantial researches of 40 years and their efforts have demonstrated that Nanotechnology can be an important tool to improve the permeability of some drugs for the blood–brain barrier. As such there is an urgent need for the development of delivery system due the existence of blood brain barrier small molecules cannot cross BBB i.e. CNS drugs. In order to improve the treatment of traumatic brain injuiry, Alzhemeirs disease, sclerosis, parkisions disorder etc. Here, we review the major advances in the development of nanoparticles for drug delivery to the CNS.


Cite this article:
Sirisha, Praveena R. A Complete Review - Nanoparticles Targeting to Brain. Asian J. Res. Pharm. Sci. 2020; 10(3):199-203. doi: 10.5958/2231-5659.2020.00038.7

Cite(Electronic):
Sirisha, Praveena R. A Complete Review - Nanoparticles Targeting to Brain. Asian J. Res. Pharm. Sci. 2020; 10(3):199-203. doi: 10.5958/2231-5659.2020.00038.7   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2020-10-3-15


REFERENCES:
1. Jain NK. Controlled and Novel Drug Delivery. 1st ed; New Delhi (2001): 292- 301.
2. Silvia V, Cristina D, Vlad, Racovita S, LunganM A, Eva L, Munteanu R. Complex micro particulate system based on glycidyl metharylate (2014):10: 340-411.
3. J.L. Gilmore, X. Yi, L. Quan, A.V. Kabanov, Novel Nanomaterials for Clinical Neuroscience. J. Neuro Immune Pharmacol. 3(2), 83–94 (2008)
4. S. Bhaskar, F. Tian, T. Stoeger, W. Kreyling, J.M. de la Fuente, V. Grazu, P. Borm, G. Estrada, V. Ntziachristos, D. Razans Multifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood–brain barrier: perspectives on tracking and neuroimaging. Part. Fibre Toxicol. 7, 3(2010).
5. K.R. Duffy, W.M. Pardridge, R.G. Rosenfeld, Human blood–brain barrier insulin-like growth factor receptor. Metabolism 37(2), 136–140 (1988)
6. C.A. Lipinski, F. Lombardo, B.W. Dominy, P.J. Feeney, Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Delivery. Revision. 23(1), 3–25 (1997)
7. F.L. Cardoso, D. Brites, M.A. Brito, Looking at the blood–brain barrier: molecular anatomy and possible investigation approaches. Brain Res. Rev. 64(2), 328–363 (2010).
8. K. Nagpal, S.K. Singh, D.N. Mishra, Drug targeting to brain: a systematic approach to study the factors, parameters and approaches for prediction of permeability of drugs across BBB. Expert Opin. Drug Deliv. 10, 927–955 (2013)
9. K.R. Duffy, W.M. Pardridge, Blood–brain barrier transcytosis of insulin in developing rabbits Brain Res. 420, 32–38 (1987)
10. W.M. Pardridge, J. Eisenberg, J. Yang, Human blood–brain barrier transferrin receptor. Metabolism 36(9), 892–895 (1987)
11. I. Brigger, J. Morizet, G. Aubert, H. Chacun, M.-J. Terrier-Lacombe, P. Couvreur, Poly (ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting. J. Pharmacol. Exp. Their. 303(3), 928–936 (2002)
12. C.A. Lipinski, Lead-and drug-like compounds: the rule-of-five revolution. Drug. Discover. Today Technol. 1(4), 337–341 (2004)
13. B. Dehouck, L. Fenart, M.-P. Dehouck, A. Pierce, G. Torpier, R. Cecchelli, A new function for the LDL receptor: transcytosis of LDL across the blood–brain barrier. J. Cell Biol. 138(4), 877–889 (1997
14. K. K. Jain, The Handbook of Nanomedicine (Springer, Dordrecht, 2012)
15. S. Bhaskar, F. Tian, T. Stoeger, W. Kreyling, J.M. de la Fuente, V. Grazu, P. Borm, G. Estrada, V. Ntziachristos, D. Razansky, Multifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood–brain barrier: perspectives on tracking and neuroimaging. Part. Fibre Toxicol. 7, 3 (2010)
16. Mu¨ ller, R., Maaben, S. Weyhers, H., Specht, F., and Lucks, J. (1996). Cytotoxicity of magnetite-loaded polylactide polylactide/glycoside particles and solid lipid Nanoparticles. International Journal of Pharmaceutics, 138, 85_94.
17. Marengo, E., Cavalli, R., Caputo, O., Rodriguez, L., and Gasco, M. R. (2015). Scale-up of the preparation process of solid lipid nanospheres. Part I. International Journal of Pharmaceutics, 205, 3_13.
18. Noack, A., Hause, G., and Ma¨der, K. (2012). Physicochemical characterization of curcuminoid-loaded solid lipid 308,405-424.
19. Manjunath, K., Reddy, J. S., and Venkateswarlu, V. (2005). Solid lipid Nanoparticles as drug delivery systems. Preparation and characterization of nitrendipine solidlipid Nanoparticles. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 66, 178_186.
20. Wolfram S, Gelperina S and Kreuter J 2012 Transport of drugs across the blood-brain barrier by Nanoparticles J. Control. Release 161 264–73
21. Lockman P R et al 2004 Nanoparticles surface charges alter blood-brain barrier integrity and permeability J. Drug Target 12 635–41
22. K. A. Woodrow, Y. Cu, C.J. Booth, J.K. Saucier-Sawyer, M.J. Wood, W.M. Saltzman, Intravaginal gene silencing using biodegradable polymer Nanoparticles densely loaded with small-interfering RNA, Nat. Mater. 8 (2009) 526–533.
23. S. L. Demento, S.C. Eisenbart, H.G. Foellmer, C. Platt, M.J. Caplan, W.M. Saltzman, I. Mellman, M. Ledizet, E. Fikrig, R.A. Flavell, T.M. Fahmy, Inflammasome-activating Nanoparticles as modular systems for optimizing vaccine efficacy, Vaccine 27 (2009) 3013–3021.

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