Prathap Kumar Kothapalli, S. Jagadeesh Sanganal, N. B. Shridhar, H.D. Narayanaswamy, M. Narayanaswamy
Prathap Kumar Kothapalli1, S. Jagadeesh Sanganal1, N. B. Shridhar1, H.D. Narayanaswamy2 and M. Narayanaswamy3
1Dept. of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore-560024, India
2Dept. of Veterinary Pathology, Veterinary College, Bangalore-560024, India
3Dept. of Veterinary Physiology, Veterinary College, Bangalore-560024, India
Volume - 4,
Issue - 4,
Year - 2014
The present study was conducted to evaluate the analgesic and anti-inflammatory activities of Ficus bengalensis leaf extract in rats using Eddy’s hot plate method and formalin induced paw oedema model, respectively. The Ficus benghalensis methanolic leaf extract tested for anti-inflammatory activity, showed a significant (P<0.001) paw volume reduction at dose of 200 mg/kg and at 3 hours. The percent inhibition in paw volume was 65.21% at 200 mg/kg as compared to 62.31% of Diclofenac indicating the anti-inflammatory activity, in formalin-induced paw-edema model. The Ficus benghalensis leaf extract also demonstrated a significant (P<0.001) analgesic activity at both 100 and 200 mg/kg. Thus it can be concluded that the Ficus benghalensis leaf extract possess a potent analgesic and anti-inflammatory activities as reflected by the parameters investigated, and demands further research to characterize the novel candidate.
Cite this article:
Prathap Kumar Kothapalli, S. Jagadeesh Sanganal, N. B. Shridhar, H.D. Narayanaswamy, M. Narayanaswamy. In-Vivo Anti-Inflammatory and Analgesic Screening of Ficus bengalensis Leaf Extract in Rats. Asian J. Res. Pharm. Sci. 4(4): Oct.-Dec. 2014; Page 174-178.