Author(s):
Ch. Srilatha, Golla Jayasri, M. Sreeja, NY. Satyanarayana, D. Ramakrishna, Mamatha Kola
Email(s):
itzz.srilatha@gmail.com
DOI:
10.52711/2231-5659.2025.00020 
Address:
Ch. Srilatha*, Golla Jayasri, M. Sreeja, NY. Satyanarayana, D. Ramakrishna, Mamatha Kola
Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Affiliated to Osmania University, Hyderabad, Telangana, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 2,
Year - 2025
ABSTRACT:
Objective: To Formulate and evaluate polyherbal toothpaste with neem, fenugreek, pomegranate peel extracts, for anti-inflammatory and anti-bacterial effects. Method: Extract of polyherbal formulations were prepared using methanol. Standard cultures of staphylococcus aureus and candida albicans, gram positive were used for the study. The antibacterial test used was the agar well diffusion method. Anti-inflammatory effect of polyherbal toothpaste was determined by protein denaturation method. Also evaluation parameters like foamability, spreadability, pH and other tests were performed and are compared with marketed herbal formulations. Results: The methanol extract of polyherbal formulation showed maximum activity against staphylococcus and candida Albicans. Evaluation parameters were conducted on poly herbal formulation and shown in tables. Conclusion: The results of the study support the traditional application of the medicinal plants and suggest that various herbs which were used in polyherbal formulation possess antibacterial and anti-inflammatory properties and this polyherbal toothpaste developed can be utilized to prevent various dental diseases.
Cite this article:
Ch. Srilatha*, Golla Jayasri, M. Sreeja, NY. Satyanarayana, D. Ramakrishna, Mamatha Kola. Evaluation of Anti-inflammatory and Anti-Bacterial Effects of Polyherbal Toothpaste with Neem, Fenugreek and Pomegranate Peel Extract. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(2):129-4. doi: 10.52711/2231-5659.2025.00020
Cite(Electronic):
Ch. Srilatha*, Golla Jayasri, M. Sreeja, NY. Satyanarayana, D. Ramakrishna, Mamatha Kola. Evaluation of Anti-inflammatory and Anti-Bacterial Effects of Polyherbal Toothpaste with Neem, Fenugreek and Pomegranate Peel Extract. Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(2):129-4. doi: 10.52711/2231-5659.2025.00020 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2025-15-2-5
REFERENCES:
1. Wright JT, Hart T C. The genome projects: implications for dental practice and education. Journal of Dental Education. 2002; 66: 659–671.
2. Taylor GW. Diabetes, periodontal diseases, dental caries, and tooth loss: a review of the literature. Compendium of Continuing Education in Dentistry. 2004; 25: 179–188.
3. Carounanidy U. A. Use of an aqueous extract of Terminalia chebula as an anticaries agent. Indian Journal of Dental Research. 2007; 18:152–156.
4. Ahmad I. Screening of some Indian medicinal plants for their antimicrobial properties. Journal of Ethnopharmaco. 1998; 62: 183-193
5. Dwivedi D, Kushwah T, Kushwah M, Singh V. Antibiotic susceptibility pattern against pathogenic bacteria causing Dental Caries. South Asian Journal of Experimental Biology. 2011; 1: 32-35.
6. Kleinberg I. A. mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis. Critical Reviews in Oral Biology and Medicine. 2002; 13: 108–125
7. Prashant GM, Chandu GN, Murulikrishna KS, Shafiulla MD. The effect of mango and neem extract on four organisms causing dental caries: Streptococcus mutant, streptococcus salivavivus, streptococcus mitis, and streptococcus sanguis: An in vitro study. Indian J Dent Res. 2007; 18(4): 148-151.
8. Shah S, Venkataraghavan K, Chaudhary P, Mohammad S, Trivedi K, and Shah S G. Evaluation of antimicrobial effect of Azadirachtaindica plant extract (SoluneemTM) on commonly found root canal pathogenic microorganisms (viz. Enterococcus faecalis) in primary teeth: A microbiological study. J Indian Soc Pedo Prev Dent. 2016; 34(3): 210-216.
9. Kokare C. Pharmaceutical Microbiology Experiments and Techniques. Career publication, Nashik. 4th Ed. 2013: 65-83.
10. George J, Hegde S, KS R, Kumar A. The efficacy of herbal-based toothpaste in the control of plaque and gingivitis: A clinico-biochemical study. Indian J Dent Res. 2009; 20(4): 480-482.