Author(s):
Pratham J. Patil, Divakar R. Patil, Akash S. Jain, Azam Z. Shaikh, Sameer R. Shaikh
Email(s):
dddivakardeore1@gmail.com
DOI:
10.52711/2231-5659.2025.00014
Address:
Pratham J. Patil1, Divakar R. Patil2, Akash S. Jain3, Azam Z. Shaikh2, Sameer R. Shaikh2
1B. Pharm. Student, Department of Pharmaceutics, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India.
2Assistant Professor, Department of Pharmaceutics, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India.
3Assistant Professor, Department of Quality Assurance, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 1,
Year - 2025
ABSTRACT:
In this review, we talk about the basics of teratology, which is the study of birth defects. We start by explaining what teratology is, when and how birth defects can happen, and what usually causes them. Teratology is a fairly new science that began in the early 1900s. It has made a lot of progress over the years, thanks to advances in areas like biology, toxicology (the study of poisons), and genetics. We've also learned more about how the environment can affect pregnancy. However, there's still a lot of work to do to reduce the risks of harmful substances that can cause birth defects. While we know what causes some birth defects, there are still many where the cause is unclear. This means more research is needed to understand how different things might cause these defects.
Cite this article:
Pratham J. Patil, Divakar R. Patil, Akash S. Jain, Azam Z. Shaikh, Sameer R. Shaikh. A Brief Review on Teratology . Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(1):92-8. doi: 10.52711/2231-5659.2025.00014
Cite(Electronic):
Pratham J. Patil, Divakar R. Patil, Akash S. Jain, Azam Z. Shaikh, Sameer R. Shaikh. A Brief Review on Teratology . Asian Journal of Research in Pharmaceutical Sciences. 2025; 15(1):92-8. doi: 10.52711/2231-5659.2025.00014 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2025-15-1-14
REFERENCES:
1. Banhidy F, Lowry RB, Czeizel AE. Risk and benefit of drug use during pregnancy. Int J Med Sci. 2005; 2:100-6.
2. Deborah E, McCarter, Spaulding MS. Medications in pregnancy and lactation. Amer J Maternal Child Nursing. 2005; 30:10-7.
3. Melton MW. Take two Aspirin or not? Risk of medication use during pregnancy. Mother Baby J. 1999; 4:25-32.
4. Marleen M.H.J. van Gelder, Iris A.L.M. Van Rooij, Richard K. Miller, Gerhard A. Zielhuis, Lolkje T.W. de Jong-van den Berg, and Nel Roeleveld; Human Reproduction Update. 2010; 16(4): 378–394
5. Mitchell AA. Research challenges for drug-induced birth defects. ClinPharmacolTher. 2016; 100(1): 26-8.
6. A.A. Mitchell, S.M. Gilboa, M.M. Werler, K.E. Kelley, C. Louik, S. Hern´andez-Díaz, N.B.D.P. Study, Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008, Am. J. Obstet. Gynecol. 2011; 205: 51.e1–51. e8.
7. J.R. Daw, G.E. Hanley, D.L. Greyson, S.G. Morgan, Prescription drug use during pregnancy in developed countries: a systematic review, Pharm. 2011; S 20: 895–902.
8. Piper JM, Baum C, Kennedy DL. Prescription drug use before and during pregnancy in a Medicaid population. Am J Obstet Gynecol. 1987; 57:148–56.
9. Lacroix I, Damase-Michel C, Lapeyre-Mestre M, Montastruc JL. Prescription of drugs during pregnancy in France. Lancet. 2000; 356: 1735–6.
10. S.H.L. Thomas, L.M. Yates, Prescribing without evidence – pregnancy, Br. J. Clin. Pharm. 2012; 74: 691–697.
11. Jones KL, Smith DW, Ulleland CL et al. Pattern of malformations in offspring of chronic alcoholic mothers. Lancet 1973; 1: 1267-1267.
12. Abel EL. Fetal Alcohol Syndrome and Fetal Alcohol Effects. New York: Plenum Press. 1983.
13. Harada Y. Congenital Minimata disease. In: Minimata Disease Study Group of Minimata Disease. Japan: Kumamoto University. 1968: 93-117.
14. Krutika Kailash Patil, Laxmi Vinod Patil, Krutadnya Purushottam Patil, Mohini Kantilal Patil, A Review on Teratology International Journal of Scientific Development and Research (IJSDR). 2022; 7(5): 2455-2631.
15. Hale F. Pigs born without eyeballs. J Hered. 1933; 24:105-10.
16. Murphy ML, Karnofsky DA. Effect of azaserine and other growth inhibiting agents on fetal development of the rat. Cancer. 1956; 9:955-62.
17. Thiersch JB. Therapeutic abortions with folic acid antagonist 4-amino pteroylglutamic acid (4-amino P.G.A.) administered by oral route. Am J Obstet Gynecol. 1956; 63:1298-304.
18. Hale F. Pigs born without eyeballs. J Hered. 1933; 24:105-06.
19. Lenz W. Thalidomide and congenital abnormalities. Lancet. 1962; 1:45.
20. Murphy ML, Karnofsky DA. Effect of azaserine and other growthinhibiting agents on fetal development of the rat. Cancer. 1956; 9:955-62.
21. Gerard G. Nahum, MD, CAPT Kathleen Uhl, USPHS, and CAPT Dianne L. Kennedy, USPHS.Antibiotic Use in Pregnancy and Lactation. American College of Obstetricians and Gynecologists. 2006; 107: 5.
22. Trent Y. Antibiotic use in pregnancy. Infectious Diseases Registrar Cairns Base Hospital. 2011; 13(3).
23. Christina H. Stack R.Ph. The General Use of Medications in Pregnancy. 1999; II(8): 4-10.
24. Thiago Mazzu-Nascimento, Débora Gusmão Melo, Giorgio Gianini Morbioli1, Emanuel Carrilho, Fernanda Sales Luiz Vianna, André Anjos da Silva and Lavinia Schuler-Faccini; Genetics and Molecular Biology. 2017; 40(2): 387-397.
25. HON Foundation. NHS Choices [Internet]. United Nations: Mother and Child Glossary. [updated on 2002 Jul 9].
26. Moore PJ. Maternal Physiology during Pregnancy. In: De Cherney AH, Pernoll ML, editors. Current obstetrics and gynecological diagnosis and treatment. 8th ed. New York: McGraw-Hill; 1994. p. 146-54.
27. Yankowitz J, Niebyl JR, editors. Drug therapy in pregnancy. 3rd ed. Philadelphia: Lippincott William Wilkins; 2001.
28. Hansen W, Yankowitz J. Pharmacologic therapy for medical disorders during pregnancy. Clin Obstet Gynaecol. 2002; 45: 136-52.
29. Kraemer K. Placental transfer of drugs. Neonatal Network. 1997; 16:657.
30. Loebstein R, Lalkin A, Koren G. Pharmacokinetic changes during pregnancy and their clinical relevance. Clin Pharmacokinet. 1997; 33:328-43.
31. Andrade SE, Gurwitz JH, Davis RL, Chan KA, Finkelstein JA, Fortman K, et al. Prescription drug use in pregnancy. Am J Obstet Gynaecol. 2004; 191:398-407.
32. Sharma R, Kapoor B, Verma U. Drug utilization pattern during pregnancy in North India. J Med Sci. 2006; 60:277-87.
33. Porter RS, editor. The Merck Manual’s Online Medical Library. Whitehouse Station: Merck Research Lab. 2004.
34. Yaffe SJ, editor. Drugs in pregnancy and lactation. 6th ed. Philadelphia: Lippincott William Wilkins. 2002.
35. Ward RW. Difficulties in the study of adverse fetal and neonatal effects of drug therapy during pregnancy. Semin Perinatol. 2001; 25:191-5.
36. Janet Uriu-Adams, George P. Daston; Teratology Primer, 3rd Edition.
37. Sarah G. Običan, Karla Leavitt, Anthony R. Scialli; Teratology Primer, 3rd Edition.
38. Sura Alwan and Jan M. Friedman; Teratology Primer, 3rd Edition.