Author(s): K. K. Jangam, D. N. Vikhe, R. S. Jadhav, G. S. Shinde

Email(s): kanchanjangam1998@gmail.com

DOI: 10.52711/2231-5659.2022.00025   

Address: K. K. Jangam*, D. N. Vikhe, R. S. Jadhav, G. S. Shinde
Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, India, 413736.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2022


ABSTRACT:
The B.1.6179 Delta variant of the severe acute metabolic process syndrome corona virus (SARS –COV-2). The virus that causes corona virus unwellness 2019 (covid -19), has contributed to a surge in cases of Republic of India and has currently been detected across the world, as well as a notable increase in cases within the UK. Delta and (B.167.2.1/(Ay.1) could be a new variant of the SARS- CoV-2. corona virus came in existence because of a mutation within the delta strain of the virus (B.1.617.2 variant). It is technically successive generation of SARS-COV-2. This mutant of delta was initial detected in Europe march 2021.The delta virus that was initial detected in Republic of India (in February 2021) eventually became an enormous downside for the total world. However, the delta variant at the moment, is restricted to smaller areas within the country. Individual’s reportable symptoms like headaches, sore throats, fluid noses, and fever. The world health organization (WHO)is following this variant as a part of the delta variant as well as for different variants of concern with extra mutations. This review provides detail idea about delta virus its treatment, prevention and methods for reduction of sensitivity.


Cite this article:
K. K. Jangam, D. N. Vikhe, R. S. Jadhav, G. S. Shinde. A Review on Variant of Concern (Delta Variant of COVID 19). Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(2):146-0. doi: 10.52711/2231-5659.2022.00025

Cite(Electronic):
K. K. Jangam, D. N. Vikhe, R. S. Jadhav, G. S. Shinde. A Review on Variant of Concern (Delta Variant of COVID 19). Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(2):146-0. doi: 10.52711/2231-5659.2022.00025   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2022-12-2-11


REFERENCE:
1.    Yadav, P. D. et al. Neutralization of variant under investigation B.1.617 with sera of BBV152 vaccinees. Clinical Infectious Diseases, https://doi.org/10.1093/cid/ciab411 (2021).
2.    Ferreira, I. et al. SARS-CoV-2 B.1.617 emergence and sensitivity to vaccine- elicitedantibodies.Biorxiv,2021.2005.2008.443253,https://doi.org/10.1101/2021.05.08.443253(2021).
3.    Hoffmann, M. et al. SARS-CoV-2 variant B.1.617 is resistant to Bamlanivimab and evades antibodies induced by infection and vaccination. Biorxiv, 2021.2005.2004.442663,https://doi.org/10.1101/2021.05.04.442663 (2021).
4.    Cherian, S. et al. Convergent evolution of SARS-CoV-2 spike mutations, L452R, E484Qand P681R, in the second wave of COVID-19 in Maharashtra, India. Biorxiv, 2021.2004.2022.440932, https://doi.org/10.1101/2021.04.22.440932 (2021).
5.    Edara, V.-V. et al. Infection and vaccine-induced neutralizing antibody responses to the SARS-CoV-2 B.1.617.1 variant. Biorxiv, 2021.2005.2009.443299, https://doi. org/10.1101/2021.05.09.443299 (2021)
6.    Tada, T. et a l. The Spike Proteins of SARS-CoV-2 B.1.617 and B.1.618 Variants Identified in India Provide Partial Resistance to Vaccine-elicited and Therapeutic MonoclonalAntibodies.Biorxiv,2021.2005.2014.444076,https://doi.org/10.1101/2021.05.14.444076 (2021).
7.    Liu, J. et al. BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants.Nature, https://doi.org/10.1038/s41586-021-03693-y (2021).
8.    Wall, E. C. et al. Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination. The Lancet 397, 2331-2333, https://doi.org/10.1016/ S0140-6736(21)01290-3 (2021).
9.    World Health Organization (WHO). SARS-CoV-2 Variants  of Concern and Variants of Interest. Geneva: WHO; 2021. Available from: https://www.who.int/en/activities/ tracking-SARS-CoV-2-variants/
10.    Melisa Fernandes, Jyoti R. Thakur, Manisha S. Gavanje. A Study to assess knowledge regarding covid-19 among Nursing students. Asian J. Nursing Education and Research. 2021; 11(1):65-67.
11.    C. Muralikrishna Goud. Coronavirus Disease 2019 - FDA Updates. Asian J. Res. Pharm. Sci. 2020; 10(4):273-281.
12.    Public Health England. Variants: distribution of case data, 11 June 2021. 18June2021. www.gov.uk/government/publications/covid-19-variants-genomically- confirmed-case-numbers/variants-distribution-of-case-data-18-june-2021.
13.    Public Health England. Effectiveness of covid-19 vaccines against hospital admission with the Delta (B.1.617.2) variant. 14 June 2021. https://khub.net/web/phe-national/public-library/-/document_library/v2Ws-RK3ZlEig/view/479607266.
14.    Public Health England. Investigation of SARS-CoV-2 variants of concern: technical briefings. 18 June 2021. www.gov.uk/government/publications/investigation- of-novel-sars-cov-2-variant-variant-of-concern-20201201.
15.    Independent SAGE. The Independent Sage Report 44: Continuing need for support measures. 18 June 2021. www.independentsage.org/wp-content/uploads/ 2021/06/Supprt-document-final.pdf.
16.    The Public Health England (PHE) Variant Technical Group. SARS-CoV-2 variants of concern and variants under investigation in England: Technical briefing 10. London: PHE. [Accessed: 15 Jun 2021]. Available from: https://assets.  publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/984274/Variants_of_Concern_ VOC_Technical_Briefing_10_England.pdf
17.    Patel MC, Chaisson LH, Borgetti S, Burdsall D, Chugh RK, Hoff CR, et al. Asymptomatic SARS-CoV-2 infection and COVID-19 mortality during an outbreak investigation in a skilled nursing facility. Clin Infect Dis. 2020;71(11):2920-6. https://doi. org/10.1093/cid/ciaa763 PMID: 32548628
18.    McMichael TM, Currie DW, Clark S, Pogosjans S, Kay M, Schwartz NG, et al. Epidemiology of Covid-19 in a longterm care facility in King County, Washington. N Engl J Med. 2020;382(21):2005-11. https:
19.    Office for National Statistics. Coronavirus (covid-19) infection survey, UK. 4 Jun 2021. https://www.ons.gov.uk/peoplepopulationandcommunity/ healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveypilot/ 4june2021#age-analysis-of-the-number-ofpeople- who-had-covid-19.
20.    United States Food and Drug Administration (FDA). Pfizer- BioNTech COVID-19 vaccine emergency use authorization review memorandum. Silver Spring: FDA; 2020. Available from: https://www.fda.gov/media/144416/download
21.    Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and efficacy of the BNT162b2 Mrna Covid-19 vaccine. N Engl J Med. 2020;383(27):2603-15. https:// doi.org/10.1056/NEJMoa2034577 PMID: 33301246
22.    Public Health England (PHE). COVID-19: the green book, chapter 14a. London, PHE. [Accessed: 11 Jun 2021]. Available from: https://assets.publishing.service.gov.uk/government/ uploads/system/uploads/attachment_data/file/984310/ Greenbook_chapter_14a_7May2021.pdf
23.    Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, et al. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021;397(10277):881-91. https://doi.org/10.1016/S0140- 6736(21)00432-3 PMID: 33617777
24.    Lopez Bernal J, Andrews N, Gower C, Robertson C, Stowe J, Tessier E, et al. Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study. BMJ. 2021;373(1088):n1088. https://doi.org/10.1136/bmj.n1088 PMID: 33985964
25.    Vasileiou ESC, Simpson CR, Robertson C, Shi T, Kerr S, Agrawal U, et al. Effectiveness of First Dose of COVID-19 Vaccines Against Hospital Admissions in Scotland: National Prospective Cohort Study of 5.4 Million People. 2021. https://doi.org/ DOI:10.2139/ssrn.3789264
26.    Shrotri M, Krutikov M, Palmer T, Giddings R, Azmi B, SubbaraoS, et al. Vaccine effectiveness of the first dose of ChAdOx1nCoV-19 and BNT162b2 against SARS-CoV-2 infection in residents of Long-Term Care Facilities (VIVALDI study). medRxiv. 2021.03.26.21254391. https://doi.org/10.1101/2021. 03.26.21254391
27.    Shyam Prasad, Pratikshya Praharaj. Indian consumers’ behaviour during COVID 19: An Exploratory Study. Asian Journal of Management. 2021; 12(2):215-0.
28.    Ritika Gupta. The Management of Coronavius Pandemic 2019-2020. Asian J. Pharm. Res. 2020; 10(4):327-330.
29.    Archana B. Chavhan, Pavan S. Jadhav, Satish Shelke. COVID 19: Outbreak, Structure and Current therapeutic strategies. Asian J. Pharm. Tech. 2021; 11(1):76-83.
30.    Khoury, D. S. et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nature Medicine, https://doi.org/10.1038/ s41591-021-01377-8 (2021).
31.    Bernal, J. L. et al. Effectiveness of COVID-19 vaccines against the B.1.617.2 variant. medRxiv, 2021.2005.2022.21257658, https://doi.org/10.1101/2021.05.22.21257658 (2021).
32.    Lustig Y, Nemet I, Kliker L, Zuckerman N, Yishai R, Alroy-PreisS, et al. Neutralizing Response against Variants after SARSCoV-2 Infection and One Dose of BNT162b2. N Engl J Med.2021;384(25):2453-4. https://doi.org/10.1056/NEJMc2104036PMID: 3382681528. Wang P, Casner RG, Nair MS, Wang M, Yu J, Cerutti G, et al.Increased resistance of SARS-CoV-2 variant P.1 to antibodyneutralization. Cell Host Microbe. 2021 May 12;29(5):747-51 e4
33.    Liu Y, Liu J, Xia H, Zhang X, Zou J, Fontes-Garfias CR, et al.BNT162b2-Elicited Neutralization against New SARS-CoV-2 Spike Variants. N Engl J Med. 2021;NEJMc2106083. https:// doi.org/10.1056/NEJMc2106083 PMID: 33979486
34.    Cherian S, Potdar V, Jadhav S, Yadav P, Gupta N, Das M, et al. Panda S Convergent evolution of SARS-CoV-2 spike mutations, L452R, E484Q and P681R, in the second wave of COVID-19 in Maharashtra, India. bioRxiv. 2021. https://doi. org/10.1101/2021.04.22.440932
35.    Callaway E. Delta coronavirus variant: scientists brace for impact. Nature. 2021 Jun 22. https://doi.org/http://dx.doi. org/10.1038/d41586-021-01696-3 . PMID: 34158664
36.    Liu C, Ginn HM, Dejnirattisai W, Supasa P, Wang B, Tuekprakhon A, et al. Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum. Cell. 2021.
37.    Available from: https://www.cell.com/action/showPdf?pii =S0092-8674%2821%2900755-8
38.    Wang P, Casner RG, Nair MS, Wang M, Yu J, Cerutti G, et al. resistance of SARS-CoV-2 variant P.1 to antibody neutralization. Cell Host Microbe. 2021 May 12;29(5):747-51 e4.
39.    Shen X, Tang H, Pajon R, Smith G, Glenn GM, Shi W, et al. Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351. N Engl J Med. 2021;384(24):2352-4. https://doi.org/10.1056/
40.    NEJMc2103740 PMID: 33826819
41.    Virtanen J, Uusitalo R, Korhonen EM, Aaltonen K, Smura T, Kuivanen S, et al. Kinetics of Neutralizing Antibodies of COVID-19 Patients Tested Using Clinical D614G, B.1.1.7, and
42.    B 1.351 Isolates in Microneutralization Assays. Viruses. 2021;13(6):996. https://doi.org/10.3390/v13060996 PMID:34073577
43.    Abu-Raddad LJ, Chemaitelly H, Butt AA, National Study Group for COVID-19 Vaccination. Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7and B.1.351 Variants. N Engl J Med. 2021;NEJMc2104974. https://doi.org/10.1056/ NEJMc2104974 PMID: 33951357
44.    Daily coronavirus news round-up Online every weekday at 6pm BST newscientist.com/coronavirus-latest
45.    www.thelancet.com Vol 397 June 26, 2021
46.    Rashmi P, Sunitha P S, Puruhit Saraswathi, Vidya M. Respiratory Hygiene in Covid harshini Jenifer, Bruce Joshua Sinclair, S. Shanmugasundaram.
47.    harshini Jenifer, Bruce Joshua Sinclair, S. Shanmugasundaram.
48.    Dietary Flavonoids as competitive Inhibitors of covid 19 major protease. Res. J. Pharmacognosy and Phytochem. 2020; 12(4):261-266. Int. J. of Advances usmita Parija. A journey through the realms of the Great Indian Diaspora and India’s diaspora engagement policy. Research Journal of Humanities and Social Sciences. 2021; 12(2):71-5.
49.    Isha Shah, Nensi Raytthatha, Jigar Vyas, Umesh Upadhyay. A Systematic Review on COVID 19 Treatment and Management. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):230-8.
50.    Anto Arockia Raj, J. Vinnarasi. Natural Potential Inhibitors for Covid 19 –
51.    An Insilico Approach. Research Journal of Pharmacy and Technology. 2021; 14(9):4913-9.
52.    https://www.mpnrc.org/delta-plus-variant-symptoms-cause-precaution-treatment/

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