The present study was under taken to develop sustained release formulations for Metoprolol tartrate , a ß-blocker for the treatment of Hypertension. The tablets were prepared by wet granulation technique by using modified starches as release retardant polymers. The evaluation involves 3 stages i.e. pre-compression, post compression parameters and in-vitro release kinetics assessment of tablets. The USP-II paddle method was selected to perform the dissolution test and 500ml of 6.8 pH phosphate buffer was used as dissolution medium at 50rpm at 37 C ± 0.5. The release kinetics was analyzed. All the formulations followed Peppa’s release mechanism. When the release data was plotted into korsmeyer-Peppas equation (log cumulative % of drug release Vs log time), it was observed that all formulations (F2 to F11) (formulated with modified starches) followed Anamalous (non- Fickian) type of mechanism. The in-vitro release studies revealed that the formulation F5(formulated with Potato Starch containing 1:4 drug :polymer ratio), F8(formulated with Corn Starch containing 1:3 drug :polymer ratio) and F11 formulated with Rice Starch containing 1:3 drug :polymer ratio) can be taken as ideal or optimized formulations for sustained release formulations as it fulfills all the requirements.
Cite this article:
T. E. Gopala Krishna Murthy, V. Akash. Development of Metoprolol Tartrate Sustained Release Formulations by using Modified Starches. Asian J. Res. Pharm. Sci. 2018; 8(4): 241-246. doi: 10.5958/2231-5659.2018.00040.1