Author(s): Manmohan S. Jangdey*, Anshita Gupta and Abhishek K. Sah

Email(s): manuiopresearch@gmail.com

DOI: Not Available

Address: Manmohan S. Jangdey*, Anshita Gupta and Abhishek K. Sah
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 2,     Year - 2014


ABSTRACT:
In the present work, the mucoadhesive tablet of diclofenac (as a model drug) by using Tamarindus indica fruit gum as a binder was formulated. The preliminary evaluation of Tamarindus indica gum showed that bulk density 0.50 ± 0.4 g/cm3, tapped density 0.35 ± 0.8 g/cm3 and angle of repose 280 ± 0.26. The six tablet formulation were prepared by using 0.25%, 0.50%, 0.75%, 1%, 1.25% and 1.50% w/w of Tamarindus indica gum by direct compression (F1,F2,F3,F4 and F5 respectively). Tablets were subjected for evaluation of uniformity of weight, hardness, friability, drug content uniformity, swelling behaviour, release rate study, mucoadhesive study, and tensile strength study. Formulation was studied for drug additive interaction (FTIR). F4 is found to be optimized formulation. The in-vitro drug release of F4 formulation exhibits complete release of Diclofenac Sodium with nonfiction first order release kinetic. The formulation F4 exhibited tensile strength 0.27 N with 10 hrs of mucoadhesion. From the study it can be conclude that the Tamarindus indica gum used as mucoadhesive sustained release tablet.


Cite this article:
Development and Evaluation of Mucoadhesive Sustained Release Tablet using Tamarindus indica Gum. Asian J. Res. Pharm. Sci. 4(2): April-June 2014; Page 77-82.


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Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231-5659 


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