Author(s): Vaishnavi Bhoite, Shrikrishna Baokar, Rajendra Patil

Email(s): Email ID Not Available

DOI: 10.52711/2231-5659.2024.00026   

Address: Vaishnavi Bhoite1, Shrikrishna Baokar2, Rajendra Patil3
1,2,3Department of Pharmaceutical Chemistry, Delonix Society's, Baramati College of Pharmacy, Barhanpur, Baramati, Maharashtra, India 413102
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2024


ABSTRACT:
Xenotransplantation, the transfer of animal organs or tissues to humans, is a promising solution to the persistent shortage of human organs for transplantation. As the demand for organ transplants rises with increasing life expectancy and the prevalence of chronic disorders, xenotransplantation emerges as a potential avenue to save lives and enhance patients' quality of life. The gap between organ supply and demand poses a significant challenge in clinical transplantation, leading to a substantial number of individuals perishing while awaiting suitable donor organs. Xenotransplantation offers a hopeful alternative by allowing the transplantation of animal cells, tissues, or organs into humans, potentially mitigating the critical shortage of human organs. This innovative approach holds the potential to address conditions such as chronic obstructive pulmonary disorders, diabetes, liver cirrhosis, and polycystic kidney diseases, ultimately improving mortality rates. As 17 people succumb daily while awaiting organ transplants, xenotransplantation stands as a promising frontier in medical research, offering a potential solution to the crisis of organ scarcity in the field of transplantation.


Cite this article:
Vaishnavi Bhoite, Shrikrishna Baokar, Rajendra Patil. Xenotransplantation: The Future of Organ Transplantation. Asian Journal of Research in Pharmaceutical Sciences. 2024; 14(2):167-0. doi: 10.52711/2231-5659.2024.00026

Cite(Electronic):
Vaishnavi Bhoite, Shrikrishna Baokar, Rajendra Patil. Xenotransplantation: The Future of Organ Transplantation. Asian Journal of Research in Pharmaceutical Sciences. 2024; 14(2):167-0. doi: 10.52711/2231-5659.2024.00026   Available on: https://ajpsonline.com/AbstractView.aspx?PID=2024-14-2-10


REFRENCES:
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2.    Cooper DKC (ed) (2018) Recollections of pioneers in xenotransplantation research. Nova Science Publishers, New York
3.    Butler JR, Ladowski JM, Martens GR, Tector M, Tector AJ. Recent advances in genome editing and creation of genetically modified pigs. Int J Surg. 2015; 23(Pt B): 217–222
4.    Taniguchi S, Cooper DK. Clinical xenotransplantation: past, present and future. Ann R Coll Surg Engl. 1997; 79:13–19.
5.    Deschamps JY, Roux FA, Sai P, Gouin E. History of xenotransplantation. Xenotransplantation. 2005; 12:91–109.
6.    Reemtsma K. Xenotransplantation--a brief history of clinical experience: 1900–1965. In: Cooper DKCKE, Reemtsma K, White DJG, editors. Xenotransplantation: The transplantation of organs and tissues between species. 1. Heidelberg: Springer; 1991. pp. 9–22.
7.    Hering BJ, Wijkstrom M, Graham ML, Hårdstedt M, Aasheim TC, Jie T, Ansite JD, Nakano M, Cheng J, Li W, Moran K, Christians U, Finnegan C, Mills CD, Sutherland DE, Bansal-Pakala P, Murtaugh MP, Kirchhof N, Schuurman HJ. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med. 2006; 12(3): 301–303.
8.    Bach F.H., Fishman J.A., Daniels N., Proimos J., Anderson B., Carpenter C.B., Forrow L., Robson S.C., Fineberg H.V. Uncertainty in xenotransplantation: Individual benefit versus collective risk. Nat. Med. 1998; 4:141–144. doi: 10.1038/nm0298-141.  

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