ABSTRACT:
Bi-layer tablet technologies is an upgraded advantageous technology that overcomes the disadvantages of the single - layer tablet. The development of pre-determined active ingredient sustained release and the inclusion of incompatible active pharmaceutical ingredients into a single unit dosage form have both been made possible through the availability of bi layer tablets to the pharmaceutical industry. One of the key design strategies for combining incompatible drugs with various indications and the same drug with a varying release rate is provided by bi layer tablets. A bi-layer tablet is appropriate for the combination of sequential release of two drugs as well as Sustained release of a tablet, wherein the first layer is for Immediate release as a loading dosage and the second layer is a maintenance dose. The best choice for drugs with low bioavailability and brief plasma half-lives is to formulate them as bi layer tablets for sustained release. Bi-layer tablets may be the best alternative to prevent physical separation from developing chemical incompatibilities across APIs and to allow for the development of many different profiles for drug release. Bi-layer tablets are currently being developed by several pharmaceutical companies for a variety of purposes, including patent extension, therapeutic use, and marketing, to name a few. As a result, the use of bi-layer tablet for analgesic, anti-inflammatory, and antihypertensive drugs is significantly different. To develop an innovative bi-layer tablet, a comprehensive mechanistic understanding must be developed through the use of dependable, analytical methods for risk management.
Cite this article:
Pratibha K. Pagar, Mitesh P. Sonawane. Recent Innovation in Manufacturing Bi-layer Tablet Technologies: An Emerging Trends Overview. Asian Journal of Research in Pharmaceutical Sciences. Sci. 2024; 14(1):81-6. doi: 10.52711/2231-5659.2024.00013
Cite(Electronic):
Pratibha K. Pagar, Mitesh P. Sonawane. Recent Innovation in Manufacturing Bi-layer Tablet Technologies: An Emerging Trends Overview. Asian Journal of Research in Pharmaceutical Sciences. Sci. 2024; 14(1):81-6. doi: 10.52711/2231-5659.2024.00013 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2024-14-1-13
REFERENCE:
1. Soni N, Joshi D, Jain V, Pal P. A Review on Applications of Bilayer Tablet Technology for Drug Combinations. Journal of Drug Delivery and Therapeutics. 2022; 12(1): 222-7.
2. Swapnil R. P, Atram S. C, Kalpesh V. S. Bilayer Tablet technology: A Review. American Journal of Pharmtech Research. 2019; 9(6): 214-225.
2. Gupta D, Pandey M, Maiti A, Pujari NM. Bilayer Tablet Technology: A Concept of Immediate Akhtar M, Jamshaid M, Zaman M, Mirza AZ. Bilayer tablets: A developing novel drug delivery system. Journal of Drug Delivery Science and Technology. 2020; 60: 102079.and Controlled Drug Delivery. Journal of Pharmaceutical Negative Results. 2023 Jan 14:503-12.
4. Raju PN, Narasu ML, Rao KN, Kumari KS, Prakash K. Preparation and characterization of bi-layer matrix tablets of amoxicillin tri-hydrate. Research Journal of Pharmacy and Technology. 2009; 2(3): 491-4.
5. Kumbhar DM, Havaldar VD, Mali KK, Dias RJ, Ghorpade VS, Londhe RB. Formulation and Evaluation of Sustained Release Tablets of Venlafaxine Hydrochloride for the treatment of Depressive disorders. Asian Journal of Pharmaceutical Research. 2017; 7(1): 8-14.
6. Purushothaman P, Sha A, Vetrichelvan T. Formulation development and Evaluation of immediate and sustained release Bilayer Tablets Containing Amitriptyline HCl and Pregabalin for the treatment of Neuropathic Pain. Asian Journal of Pharmacy and Technology. 2017; 7(3): 127-36.
7. Manidipta D. Bilayer tablet technology: An overview. Journal of Pharmacy Research. 2012; 5(1): 310-314.
8. Devtalu SV, Patil AE, Bari MM, Barhate SD. A Review on Novel Approach–Bilayer Tablet Technology. International Journal of Pharmaceutical Sciences Review and Research. 2013;21(1):46-52.
9. Sanghavi S, Polara M, Patel M, Patel J, Shah N. Bilayer tablets–A Review of state of Art. Research Journal of Pharmaceutical Dosage Forms and Technology. 2012; 4(3): 160-5.
10. Kale SS, Saste VS, Ughade PL, Baviskar DT. Bilayer tablet. International Journal of Pharmaceutical Sciences Review and Research. 2011; 9(1): 25-30.
11. Mujoriya RZ, Singh DC, Gupta VA, Bisen A, Bondre AB. Formulation development and evaluation of metoprolol succinate ER and amlodipine besilate bilayer tablet. Research Journal of Pharmacy and Technology. 2010; 3(4): 1291-4.
12. Kumar AH, Kavitha K, Kumar SA, Kumar MR, Singh SD. Novel Approach of Bilayer Tablet Technology-A Review. International journal of pharmaceutical, Chemical and Biological Sciences. 2013; 3(3).
13. Ray MR, Bose SK, Sengupta K. Design, Development and In Vitro Evaluation of Directly Compressed Sustained Release Matrix Tablet of Famotidine. Research Journal of Pharmacy and Technology. 2008; 1(3):175-8.
14. Bhowmik D, Bhanot R, Kumar KP. Extended Release Drug Delivery-An Effective Way of Novel Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology. 2018; 10(4): 233-44.
15. Sandhyarani T, Srinath B, Surya C, Reddy P, Sowmya C. Bilayer Tablet and It’s Technology: An Overview. 2014 Sep 17:719-726.
16. Annapurna U, Priyanka KS. Bilayer Tablets-A Review. Research Journal of Pharmacy and Technology. 2019; 12(1): 385-90.
17. Chauhan M, Suthar S, Shah A, Polara M, Patel M, Patel J. Bilayer tablet: Immediate release and sustain release: A review. Research Journal of Pharmacy and Technology. 2012; 5(6): 716-20.
18. Joseph D, Thomas GM. A review on current applications of bilayer tablets. Research Journal of Pharmacy and Technology. 2019; 12(5): 2539-44.
19. Ratnaparkhi MP, Ganesh VR. Bi-layered Tablet Technology with Recent Advancement-A Review. Research Journal of Pharmacy and Technology. 2014; 7(10): 1158-64.
20. Sangeetha R, Pillai MK, Haribabu Y. Bi-layer tablets: A flexible technology for oral drug delivery-An updated review. Research Journal of Pharmacy and Technology. 2021; 14(1): 547-51.
21. Joshi S, Jaybhaye A, Deshmukh G. Bilayer tablet technology: A novel approach. Research Journal of Pharmacy and Technology. 2013; 6(12): 1443-51.
22. Shukla S, Pandya V, Bhardia P, Jonwal N, Bhatt D. Bi-layer Tablet system–An Innovative trend. Asian Journal of Pharmaceutical Research. 2013; 3(2): 49-56.
23. Singh A, Das S, Gupta S, Ghosh S. The Challenges of Producing Bilayer Tablet: A Review. Journal of Drug Delivery and Therapeutics. 2021; 11(4-S): 171-5.
24. Kumar PA, Surendrabhoopathi G, Kulakarni SV. Current Innovation in Layered Tablet Technology. Asian Journal of Research in Pharmaceutical Science. 2013; 3(4): 189-94.
25. Patil MB, Salve PM, Sonawane SV, Maru AD, Bhadane JS, Surawase RK. Technologies in Bilayer Tablet Manufacturing: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3): 253-8.
26. Akiladevi D, Nappinnai M, Sudha T. A Study on the Effect of disintegrants and Processing Methods on the Physicochemical and In Vitro Release Characteristics of Immediate Release Tablets of Bosentan Monohydrate. Asian Journal of Research in Pharmaceutical Science. 2017; 7(4): 222-6.
27. Lachman L, Liberman H and Kanig J. The theory and practise of industrial pharmacy. Varghese Publishing House, Mumbai. (1987); Edn: 297.