Author(s): Vishal Kaundal, Dheeraj Singh, Vipasha, Arti Devi, Shammy Jindal, Amar Deep Ankalgi, Kamya Goyal


DOI: 10.52711/2231-5659.2022.00005   

Address: Vishal Kaundal1, Dheeraj Singh1, Vipasha2, Arti Devi1, Shammy Jindal3, Amar Deep Ankalgi1, Kamya Goyal1*
1Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India.
2Department of Pharmacology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India.
3Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2022

Chalcones and their derivatives have been an area of great interest for several researchers in recent years. Several number of research publications have been published and chalcones continue to show promising effect for novel drug investigations. Chalcone is an advantaged moiety with therapeutic importance as it comprises of receptive ketoethylenic moiety – CO–CH=CH– having a place with flavonoids. Chalcones (1, 3-Diphenyl-prop-2-en-1-one) consists of a three carbon a, ß-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. The presence of a highly reactive a, ß-unsaturated carbonyl system in chalcone and its derivatives is the justification for its pharmacological potencies. However, synthesis in laboratory of broad range of chalcones has also been reported. Chalcones show a wide range of pharmacological impacts like anthelmintic, antileishmanial, antifungal, antimalarial, antioxidant, antiviral, antibacterial, antiulcer, antimycobacterial, insecticidal, antigout, antihistaminic, antiprotozoal, insecticidal, anticancer, antidiabetic, anti-inflammatory, analgesic etc. Chalcones can be synthesized through Claisen–Schmidt's condensation, Heck's reaction, Aldol condensation reaction, Suzuki's reaction, from cinnamic acid, Sonogashira Isomerization Coupling reaction, Microwave assisted synthesis etc. The purpose of the present review is to centralize the various and widely employed methods of synthesis of chalcone and their various derivatives and their antimicrobial and antioxidant activities.

Cite this article:
Vishal Kaundal, Dheeraj Singh, Vipasha, Arti Devi, Shammy Jindal, Amar Deep Ankalgi, Kamya Goyal. A Laconic Review on Chalcones: Synthesis, Antimicrobial and Antioxidant activities. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(1):21-8. doi: 10.52711/2231-5659.2022.00005

Vishal Kaundal, Dheeraj Singh, Vipasha, Arti Devi, Shammy Jindal, Amar Deep Ankalgi, Kamya Goyal. A Laconic Review on Chalcones: Synthesis, Antimicrobial and Antioxidant activities. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(1):21-8. doi: 10.52711/2231-5659.2022.00005   Available on:

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