Ten potential antibiofilm agents (N-acetylcysteine (NAC), ambroxol, piroxicam, diclofenac sodium, ketoprofen, 4-nitropyrdidine-N-oxide (4NPO), sodium ascorbate, sucralose, xylitol and sorbitol) showed varied activity against pre-formed biofilms formed by twenty clinical isolates of Pseudomonas aeruginosa as demonstrated by minimum biofilm inhibitory concentration (MBIC). 4NPO was the most active; Diclofenac sodium, ketoprofen, N-acetylcysteine, ambroxol, sodium ascorbate and piroxicam showed moderate activity, while sucralose, xylitol, and sorbitol demonstrated weak activity.
Cite this article:
Hisham A. Abbas, Fathy M. Serry, Eman M. EL-Masry . Combating Pseudomonas aeruginosa Biofilms by Potential Biofilm Inhibitors . Asian J. Res. Pharm. Sci. 2(2): April-June 2012; Page 66-72.