Author(s): I.E. Otuokere

Email(s): tosmanbaba@yahoo.com

DOI: Not Available

Address: I.E. Otuokere
Department of Chemistry, Michael Okpara University of Agriculture, Umudike
*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2014


ABSTRACT:
Lisinopril (N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline) is a drug of the angiotensin-converting enzyme (ACE) inhibitor class used primarily in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. Molecular mechanics potential energy function of Lisinopril was performed by conformational analysis and geometry optimization method using ArgusLab 4.0.1 software. The minimum potential energy was calculated by geometry convergence function. The most feasible potential energy for lisinopril to act as angiotensin-converting enzyme (ACE) inhibitor was found to be 78.73178401 kcal/mol


Cite this article:
I.E. Otuokere . Molecular Mechanics Potential Energy Function of Angiotensin-Converting Enzyme (ACE) inhibitor, Lisinopril. Asian J. Res. Pharm. Sci. 4(3): July-Sept. 2014; Page 118-124.


Recomonded Articles:

Asian Journal of Research in Pharmaceutical Sciences (AJPSci) is an international, peer-reviewed journal, devoted to pharmaceutical sciences....... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231-5659 


Recent Articles




Tags