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Asian Journal of Research in Pharmaceutical Sciences
ISSN: 2231-5659(Online), 2231-5640(Print)
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Antidepressant activity of ethanolic extract of leaves of Centella asiatica. Linn by In vivo methods.
P. Thamarai Selvi
M. Senthil Kumar
P. Thamarai Selvi*, M. Senthil Kumar, R. Rajesh, T. Kathiravan
Department of Pharmacology, Annai Veilankanni’s Pharmacy College, Chennai-15, India
The antidepressant activity of ethanolic extract of Centella asiatica .Linn (Umbelliferae) were studied at doses of 100mg and 200mg/kg against forced swimming test in rodents. Imipramine (30mg/kg, i.p) was selected as reference standard and it showed significant antidepressant activity in rodents. A dose dependent reduction in immobility time was observed in FST. Whereas the extract significantly increases the exploratory behaviour in mice. The finding from the present investigation indicates that extract has significant antidepressant activity as shown by its effects on different experimentally induced different models.
Centella asiatica, Antidepressant, Forced swimming, Hole board test.
P. Thamarai Selvi, M. Senthil Kumar, R. Rajesh, T. Kathiravan. Antidepressant activity of ethanolic extract of leaves of Centella asiatica. Linn by In vivo methods. Asian J. Res. Pharm. Sci. 2(2): April-June 2012; Page 76-79.
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