Volume No. :   5

Issue No. :  3

Year :  2015

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Experimental Evaluation of Antidepressant activity of Aqueous and Chloroform Leaf and Shoot Extracts of Eicchornia crassipes Linn in Mice



Address:   Praveen Kumar Uppala1*, Dr. K. Atchuta Kumar2, Sujit Kumar Patro3, Murali Krishna. B1
1Bhaskara Institute of Pharmacy, Affiliated to Andhra University, Visakhapatnam
2Principal, Bhaskara Institute of Pharmacy, Affiliated to Andhra University, Visakhapatnam
3Associate Professor, Bhaskara Institute of Pharmacy, Affiliated to Andhra University, Visakhapatnam
*Corresponding Author
DOI No:

ABSTRACT:
The main objective of the study to evaluate the Anti-depressant activity of aqueous and chloroform extract of Eicchornia crassipes in Forced swim test (FST), Tail Suspension test (TST) in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, saponins, amino acids, gums and mucilage. AEEC and CEEC did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, CEEC showed diminution of duration of immobility time in 200mg/kg but not in 100mg/kg. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, CEEC showed more antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission compared to AEEC in mice.
KEYWORDS:
Eicchornia crassipes, Aqueous extract of Eicchornia crassipes, Chloroform extract of Eicchornia crassipes, Forced swim test, Tail suspension test
Cite:
Praveen Kumar Uppala, K. Atchuta Kumar, Sujit Kumar Patro, Murali Krishna. B. Experimental Evaluation of Antidepressant activity of Aqueous and Chloroform Leaf and Shoot Extracts of Eicchornia crassipes Linn in Mice. Asian J. Res. Pharm. Sci. 5(3): July-Sept.; Page 139-144.
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