Jatropha curcas: A Review
Shivani Sharma1*,
Hitesh K. Dhamija2, Bharat Parashar3
1Research Scholar,
Department of Pharmacy, Manav Bharti
University, Solan (H.P).
2Assistant Professor,
Department of Pharmacy, Manav Bharti
University, Solan (H.P).
3HOD and Associate
Professor, Department of Pharmacy, Manav Bharti University, Solan (H.P).
*Corresponding Author E-mail: shivanimpharma@gmail.com
ABSTRACT:
Jatropa curcas belongs to
the family Euphorbiaceae.
The uses of are various parts of Jatropa plant are well known to Indian rural
population from ages. The latex of Jatropa has anti-cancerous properties, roots act as an antidote
for snakebite, oilcake is used as manure, and leaves are used as a food for Tasser silk moths. Forestation and re-forestation of
degraded wastelands with Jatropa
can convert unproductive lands into productive national assets. Jatropa is
seen by many to be the perfect biodiesel crop for India. All
parts of Jatropha (seeds, leaves and
bark) have been used in traditional medicine and for veterinary purposes for a
long time. Uses of various parts of Jatropha
in the treatment of disease. Some compounds (Curcacycline
A) with anitumor activities were reportedly found in
this plant. Substances such as phorbol esters, which
are toxic to animals and humans, have been isolated and their molluscicidal, insecticidal and fungicidal properties have
been demonstrated in lab-scale experiments and field trials. The seed oil can
be applied to treat eczema and skin diseases and to some other rheumatic pain. Rhizomes infusion or decoction is recommended in paraguyan traditional medicine as a digestive to treat
rheumatism human gout and to induce abortion.
Diagnosis by case history and presenting symptoms. A
definite diagnosis
can only be made if there is a history of ingestion and the ingested plant
material has been positively identified as Jatropha. Jatropha is generally used for the
preparation of diesel oil. Jatropha has gained importance worldwide due to its
medicinal uses and for the preparation of oil.
KEYWORDS: Jatropha curcas,
Anti-cancerous, Antidote, Traditional medicine, Diagnosis.
Jatropha curcas
belongs to the family Euphorbiaceae. The
genus name Jatropha is derived from the Greek
“iatros” (doctor) and “trophe”
(food) as
related to its medical use. It is known in English as “physic nut” or “purging
nut”, in Dutch as “Purgeernoot” or “Schijtnoot” and in Arabic as “hab
el meluk” [1]. Fortunately, inedible vegetable oils, mostly produced by
seed-bearing trees and shrubs can
provide an alternative. With no competing food uses, this characteristic turns
attention to Jatropha curcas,
which grows in tropical and subtropical climates across the developing world.[2]
VERNACULAR NAME:
SANSKRIT-Kananaeranda,
parvataranda;
HINDI- Bagbherenda, Jangliarandi, Safedarand;
BENG.- Bagbherenda, Erandagachh;
MAR.- Mogalierenda, Ranayerandi;
GUJ.- Jamalgota, Ratanjota;
TEL.- Nepalamu, Peddanepalamu, Adaviamidamu;
TAM.- Kadalamanakku, Kattamanakku;
KAN.- Adaluharal, Bettadaharalu, Maraharalu, Karnocchi;
MAL.- Kattavanakka, Kadalavanakka;
ORISSA- Jahazigaba;
ASSAM- Bongalibhotora,
GARO HILLS -Borbandong.
BOTANICAL CLASSIFICATION::
Kingdom:
Planae,
Order:
Malpighiales,
Family:
Euphorbiaceae,
Subfamily:
Crotonoideae,
Tribe:
Jatropheae,
Genus : Jatropha L.
OTHER SPECIES OF JATROPHA:
Jatropha glandulifera Roxb, Jatropha gossypifolia Linn., Jatropha multifida Linn., Jatropha nana Dalz. and Gibs., Jatropha panduraefolia Andr., Jatropha podagrica Hook.
DESCRIPTION:
Jatropha
curcus L. is a large shrub 3-4m high occurring almost throughout
India. Leaves are alternately arranged, 10-15cm x 7.5-12.5 cm, they are broadly
ovate, conate, acute usually palmately
3 or 5 lobed, glabrous; flowers in loose panicles of the cymes, yellowish
green, fruits are 2.5cm, long ovoid ,black, seeds are ovoid – oblong, dull
brownish black. The seeds are collected and exported for the extraction of oil.
The seed resembles castor seed in shape but are smaller in size and dark brown
in colour.
CULTIVATION
AND COLLECTION:
Soil and climate: Jatropha curcus grows almost everywhere even
in any kind of soil it may be sandy, acidic or alkaline or having
pH ranging from 5.5 to 8.5. Jatropha curcus donot need any special
requirement for the plantation.
Propagation:
Propagation of Jatropha on
large scale is done by both seeds and stem cuttings. Cultivation by seeds is
done in commercial cultivation. For sowing well developed and plumpy seeds
are selected. Before sowing of seeds, seeds are socked in cow dung solution for
12 hours and then kept under the wet gummy bags for 12 hours. For good
germination of seeds hot and humid weather is preferred. Seeds or cuttings can
be directly planted in the field.
Seed rate:
In one hectare of field
about 5-7.5 kg seeds are required for plantation. If the propagation is done by
stem then fruiting starts from 2nd year but if the propagation is
done by seeds then it will take 1 year more for fruiting.
Planting in field:
Before plantation of seeds
the land should be ploughed once or twice depending upon the nature of soil. In
direct planting the seeds or cuttings should be planted in the main field with
the onset of monsoon having space between them of 3 x 2m. Actual spacing
depends on the condition of the soil.
Aftercare:
Two or three weedings are necessary for plantation of seeds if the
plantation is done in rainy season then supplementary irrigation is not
required. Jatropha is deciduous in nature. The
organic matter from fallen leaves increases the fertility of the soil.
Manuring:
Manuring is necessary for the plantation of seeds depending
upon the soil nature NPK should be applied near the crown following ring method
before the propagation of seeds. Generally the application of super phosphate
improves the yield of plant from second year.
Intercropping:
Some shade loving crops like
tulsi, smilax china and other crops are grown under Jatropha for the
first two years. Jatropha
plantation gives first harvest of leaves after four months of planting. Short
duration pulses and vegetables can be cultivated under jatropha successfully.
Harvesting:
In
rainy season flowering occurs and the plant bears fruits and matures in winter.
Pods are collected when they are turned yellowish and after drying seeds are separated mechanically
or manually. Flowering is less and delayed when grown in shady conditions. In
July –September more flowering occurs. The dried pods are collected and seeds
are separated either manually or mechanically. Seeds are dried for 4-5 days to
reduce moisture level 10% before packing.
Image of Jatropha curcas
ETHANOBOTANICAL USES :
It is traditionally used in
the treatment of scaticia, dropsy, paralysis,
rheumatism, dysentery, diarrohea and various skin
diseases. Seeds are used to treat arthritis, jaundice and contractives.
Nuts are used as contraceptives. Bark is used as fish poison. Bark is used as
fish poison. Latex is used to inhibit watermelon mosaic virus. Shrub is used in
hepatotoxicity and antiobesity.
Tender/twig/stem are used in toothache, gum
inflammation, gum bleeding, pyorrhoea. Plant sap is
used in dermatomucosal disease. Plant extract is used
in the treatment of allergies, burns, cuts, wound inflammation, leprosy, leucoderma and smallpox. Water extract of branches used to
treat HIV and tumor. Plant extract is used to treat wound healing.
Uses of different parts
of J. curcas
L. in medicines [3-6]:
Part used |
Uses |
Seeds |
To treat arthritis, gout, jaundice and contraceptives |
Nuts |
Contraceptive |
Bark |
As fish posion. |
Latex |
To inhibit watermelon mosaic virus |
Shrub |
Hepatoprotective and antiobesity |
Tender/twig/ stem |
Toothache, gum inflammation, gum bleeding, pyorrhoea |
plant sap |
Dermatomucosal disease |
Plant extract |
Allergies, burns, cuts , wound inflammation, leprosy, leucoderma and smallpox |
Water extract of branches |
HIV, tumor |
Plant extract |
Wound healing |
REPORTED
PHARMACOLOGICAL ACTIVITIES:
Antioxidant
effect and associated changes in antioxidant enzymes in controlling browning
and necrosis:
Shoots of Jatropha curcus shows anti-oxidant activity, shoots contain
higher concentration of glutathione reductase, ascorbate peroxidise and guiacol peroxidise. Shoots having
anti-oxidant enzymatic protective system which determine the ability of
oxidative stress and upregulation of enzyme help to
reduce the built up of reactive oxygen species. Acetic acid plays a great role
in controlling lethal browning and disease incidence of tissue culture shoots.
High activity increases concentration in tissue which triggers programmed cell
death and ultimately causes browning and necrosis. The imbalance between
production and antioxidant defences results in
oxidative damage of photosynthetic machinery in chloroplasts resulting in
tissue browning/necrosis. [7]
Coagulant and
anticoagulant activities:
In the presence of 1 ml (1.05 g) of whole latex, the
mean of clotting time was significantly (P< 0.01) reduces from 5.83+- 1.25
to 3.83+- 1.01 minute with a range of 2-5 minutes. Use of control i.e. PBS
instead of latex, increasing the mean clotting time to 6.29+-1.28 minute with
the range of 5-9. It was also observed that the clotting time increasing as the
dilution i.e. volume of latex increasing. So clotting time is inversely
proportional to each other. [8]
Antibacterial
Diterpenoids:
Japodagrin and japodagrone are two macrocylic diterpenoids having lathyrane and jatrophone
skeletons, isolated from root of Jatropha podagrica Hook. This compound showed antibacterial
activity against some gram-positive bacteria. Japodagrin
was active against Bacillus subtilis and Staphylococcus aureus,
Japodagrone only showed activity against B.subtilis, japodagrone showed activity against B.subtilis. Along with this the
hexane, chloroform, and methanolic extract also
showed activity against gram positive bacteria in agar disk diffusion assay. [9]
Anti-Inflammatory
Activity:
Methanolic extract of Jatropha curcus obtained from the roots showed anti-inflammatory
activity against carrageenan induced rat paw odema.
[10]
Pregnancy
terminating effect:
The fruits of Jatropha curcus showed abortifacient
activity, Foetal resorption
activity. The methanol, petroleum ether and dichloromethane extract of fruit
showed abortifacient property in rats. 100%
Anti-fertility effect was observed when female rats were fed with fruit and
seeds. The anti-fertility effect of Jatropha curcus may be due to the presence of cytotoxic agent jatrophone. [11]
Anti-diabetic
activity:
50% of ethanolic extract of leaves of Jatropha curcus L.
shows antihyperglycemic effect was studied in normal
or alloxon induced diabetic rats. [12]
Anthelmintic activity:
Aqueous extract of leaves of Jatropha curcus shows anthelmintic
activity against Pheritima poshtuma. [13]
Anti-diarroheal activity:
The methanolic extract of
roots of Jatropha curcus shows
anti-diarroheal activity in various species of albino
mice. The result indicates that methanolic extract of jatropha curcusin combition of elevated prostaglandins biosynthesis and
reduce propulsive movement of small intestine. [14]
Anti-ulcer
activity:
Methanolic extract of Jatropha curcus showed
anti-ulcer activity by using aspirin induced gastric lesions in whister
rats. [15]
Anti-diabetic
and related action:
Chloroform extract of leaves of jatropha curcus at different doses shows antidiabetic activity in albino rats. It decreases the
elevated level of serum glucose and also reverse the
cholesterol, triglyceride values when compared with untreated diabetic rats.
[16]
Gastroprotective effect and cytotoxicity of terpenes:
Rhizomes of Jatropha isabelli possesses gastroprotective
activity. Rhizomes infusion or decoction is recommended in paraguyan
traditional medicine as a digestive to treat rheumatism human gout and to
induce abortion. [17]
Reported phytoconstituents:
Aerial
part of the plant contains organic acids (o and p-coumaric
acid, p-OH-benzoic acid, protocatechuic acid, resorsilic acid), saponins and
tannins. Stem bark contains amyrinsitosterol and
taraxerol30. Leaves contains cyclic triterpenes stigmasterol,
stigmasterol-5-en-3,7diol, cholest-5-en-3,7diol, campesterol,
sitosterol, 7-keto-sitosterol, 7-keto-sitosterol as
well as the d-glucoside of sitosterol.
Flavonoids
apigenin, vitexin, isovitexin. Leaves also contain the dimer of the triterpene terpene alcohol (C63H11709) and flavonoidal
glucoside30, 31, 32. Latex contain curcacyline A, a
cyclic octapeptide curcain
(a protease)33. Seeds contain curcin,
a lectin Curcin, a lectin Phorbolesters Esterases (JEA) and Lipase (JEB). Kernal
and press cake contains phytate saponin
and a trypsine inhibitor34. Roots contain Sitosterol and its d-glucoside, marmesin, propacin, the curculathyranes A and B and the curcusone
A-D, diterpenoids jatrophol
and jatropholone A and B, the coumarin
tomentin, the coumarin –lignan jatrophin as well as
taraxerol35,36 . [18-23]. Seed and oil contain phorbol
esters.[24]. Deffated meal of Jatropha contain protein (58-66) and phytate)
(9-11%).It has 66% phytate and 22% crude protein.
[25]. Seed oil contains four fatty acid-palmitic
acid, stearic acid, oleic acid and linolic acid. [26]. Jatropha meals/seeds
contain very high quantity of trypsin and phytate inhibitors. [27]. Crude Jatropha oil contains 78-80% of phorbol esters.
[28]. The fatty acid composition of jatropha curcus oil is palmitic acid(C16:0),strearic acid(C18:2),oleic
acid(C18:1) and linoleic acid(C18:2). Other fatty
acids it contains include capric acid, mysteric acid (C14:0), palmitoleic
acid (C16:1), linolenic acid(C18:3),
arachidic acid(C20:0), behenic
acid(C22:0), cis-11-eicosenoic acid (C20:1) and cis -11,14-eicosadienoic
acid(C20:2). [29]
Curcusones A–D (1 – 4) [30]
R1 R2
1 Me H
2 H Me
3 Me OH
4 OH Me
Lathyranes A (5) and B (5) [31]
5 Lathyranes A
6 Lathyranes A
Japodagrin
(1) and japodagrone (2 )[9]
Bio-diesel
production from Jatropha curcas L.
(JCL)has become a booming business. The JCL oil
contains more than 75% unsaturated fatty acid, which is reflected in the pour
and cloud point of the oil. The fatty acid composition of JCL oil is dominated
by oleic acid (C18:1) and linoleic acid (C18:2).[32]
ACKNOWLEDGEMENT:
I
would like to thank my parents, and my respected teachers (which I listed
above) who helped me a lot to complete this review article.
CONCLUSION:
Jatropha curcas is a
medicinal plant belongs to family Euphorbiaceae.It
has several uses as a medicinal plant in various diseases like gout, jaundice, tumour, wound healing, toothache, blood cogulation
from various ages. Plant extract is used in the treatment of allergies, burns,
cuts, wound inflammation, leprosy, leucoderma and
smallpox. Water extract of branches used to treat HIV and tumor. Plant extract
is used to treat wound healing. Various parts of the plant are used in the
treatment of various diseases. The fatty acid composition of jatropha curcus oil is palmitic acid (C16:0), strearic
acid (C18:2), oleic acid (C18:1) and linoleic acid
(C18:2). Other fatty acids it contains include capric
acid, mysteric acid (C14:0), palmitoleic
acid (C16:1), linolenic acid (C18:3), arachidic acid (C20:0), behenic
acid (C22:0), cis-11-eicosenoic acid (C20:1) and cis
-11, 14-eicosadienoic acid (C20:2). Thus Jatropha curcas is a worldwide used plant because
of its medicinal uses and is very effective in the treatment of various
diseases.
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Received on 26.06.2012 Accepted
on 30.07.2012
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