Optimization of Ayurvedic Herbal Medicines by Nanoformulation

 

Vaibhav S. Suryawanshi*, Akshay R. Yadav, Rushikesh M. Birajdar, Nisha M. Jagtap, Ganesh B. Vambhurkar, Pramod A. Patil

Rajarambapu College of Pharmacy, Kasegaon, Dist – Sangli, Maharashtra, India – 415404.

*Corresponding Author E-mail: vaibhava1818@gmail.com

 

ABSTRACT:

Ayurvedic medicines are mostly obtained from natural sources like plant roots, leaves, fruits, bark and seeds. It is oldest alternative medicine system and has been proved its therapeutic efficacy and usefulness. Very less or no adverse effects and side effects is the major advantage of Ayurvedic medicines in comparison to allopathic or other alternative medicine system. But problems like slow onset of action and prolong therapy time are occurs incase of ayurvedic medicine. But these problems we can solved by optimizing the ayurvedic medicines by preparing the Ayurvedic medicines in the form of Nano formulations like Nanosuspension, Nanoemulsion, Solid lipid Nanoprticles etc. is prooved from this experiment.

 

KEYWORDS: Ayurvedic medicines, Nanoparticles, Nanoemulsion, Neem, Turmaric.

 

 


INTRODUCTION:

Ayurvedic medicine is one of the world’s oldest holistic healing systems[1]. It was developed more than 3,000 years ago in India. Ayurvedic medicines are mostly obtained from natural sources like plant roots, leaves, fruits, bark and seeds[2]. It is oldest alternative medicine system and has been proved its therapeutic efficacy and usefulness. Very less or no adverse effects and side effects is the major advantage of Ayurvedic medicines in comparison to allopathic or other alternative medicine system[3]. But slow onset of action and prolong therapy time is major problem faced by this natural medicines. Allopathic medicines have been showed very fast therapeutic actions and quick onset of action but adverse and side effect is major disadvantage of this type of medicines[4] [5].

 

To overcome this problems our research work is based on optimization of pharmacological actions of less harmful and very effective Ayurvedic medicines by formulating these medicines in Nano formulations like Nanosuspension Nanoemulsion, Solid lipid Nanoparticles etc. Nano formulations has been proved its therapeutic efficacy due to nano particles size formulation enables rapid absorption of drug in systemic circulation and maximum plasma concentration of drug which boost the overall therapeutic efficacy of drug[6][7].

 

OBJECTIVES:[8]

1.    To optimize time require for onset of action of slowly acting Ayurvedic medicines

2.    To improve therapeutic efficacy of Ayurvedic medicines this shows less or no adverse effects.

3.    To develop advance formulations for older Ayurvedic medicine system by using Nano formulations.

4.    To develop medicines which may similar in comparison with allopathic medicines but without any side effects?

5.    To optimize the pharmacological actions of ayurvedic drugs by advanced nanotechnology.

METHODOLOGY:

Selection of Ayurvedic drug categories with its pharmacological actions:

Categories of Ayurvedic drugs will be selected as follow,

 

Table 1: Ayurvedic drugs selected for formulation

Sr. No.

Ayurvedic drug          

Category

Use

1

Neem

Antibacterial

To kill bacteria

2

Turmeric

Antifungal

To kill fungi

 

Extraction of crude drugs:

Various crude drugs will be extracted in suitable solvent by suitable extraction procedure like soxhlet extraction.

 

Selection of Nano formulations:

Nanoemulsion and Nanosuspension are selected formulation for project.

 

Formulation:

Preparation of Nanoemulsion and Nanosuspension with various Ayurvedic crude drugs. The method for formulation will be ultrasonication /high pressure homogenization depends of need of formulation.

 

Procedure:

Neem, tween 20 and distilled water were used in preparation of water based (o/w) emulsion. The emulsions contained Neem and surfactant with ratio 1:4.5. Each emulsion with micro scale droplet was sonicated for 30 mintutes and 45 minutes by using a high energy sonication in sonicator So Nanoemulsion were prepared. The Nanoemulsion particle sizes were determined using DLS device.  

 

Characterization and optimization of Nan formulations Particle size analysis by scanning electron microscopy (SEM)

 

 

Fig. 1: SEM of formulation

 

 

 

 

 

 

 

Evaluation of various activities:

 

Fig. 2: Antimicrobial activity of Formulation

 

RESULT AND DISCUSSION:

Table 2: Antimicrobial activity

Name of species of bacteria

zone of inhibition of micro emulsion (cm)

Zone of inhibition of Nanoemulsion (cm)

E. Coli

1.1

2

Bacillus

1.4

1.9

Aspargillus Niger

2.2

3.2

Candida

3.1

3.4

 

From above chart it is observe that, the zone of inhibition of Nanoemulsion containing Petri plate is higher or more than micro emulsion Petri plate. Hence antibacterial and antifungal activity of nanoemulsion is greater than as compare to micro emulsion.

 

CONCLUSION:

From obtained results we can conclude that Nanoemulsion shows better results than that of microemulsion because of smaller size of the oil droplets, it means that we can improve the onset of action of Ayurvedic medicin by preparing the Nano formulations like Nanoemulsion, Nanoparticles, Nanoparticle.

 

REFERENCE:

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4.       Boursier CM., Bosco D., Coulibaly A., Negre M. Journal of Crop Protection, 2011; 30: 318-322.

5.       Mason TG., Wilking JN., Meleson K., Chang CB., Graves SM. J. Phys.: Condense, 2006: 18: 635– 666.

6.       Rajasekaran C., Meignanam E., Vijayakumar V., Kalaivani T., Ramya S., Premkumar N., Siva R., Jayakumararaj R. Ethnobotanical Leaflets, 2008; 12: 1213-1217.

7.       Chiang P., Li B. J. Ultrasonic Sonochem, 2012; 19: 192–197.

8.       Nakabayashi K., Amemiya F., Fuchigami T., Machida K., Takeda S., Tamamitsub K., Atobe M. J.Chem. Commune, 2011; 47: 5765–5767.

 

 

 

 

 

 

Received on 07.01.2019                Modified on 28.01.2019

Accepted on 20.02.2019            © A&V Publications All right reserved

Asian J. Res. Pharm. Sci. 2019; 9(1):55-56.

DOI: 10.5958/2231-5659.2019.00009.2